Fred Hutchinson Cancer Center

This early-phase study tests a personalized vaccine made from unique markers on a patient's own tumor. The goal is to help the immune system fight advanced breast cancer, melanoma, and lung cancer that has not responded to other treatments. About 25 adults with these cancers will…

This study is for older adults with myelofibrosis or related blood cancers who are getting a donor stem cell transplant. Researchers want to see if adding the drug ruxolitinib to standard anti-rejection medicines can lower the risk of graft-versus-host disease (GVHD), a serious s…

This study is for adults with certain blood cancers (like acute myeloid leukemia) that have come back or not responded to standard treatment. Participants receive a strong chemotherapy combination (CLAG-M or FLAG-Ida) followed immediately by a stem cell transplant from a donor. T…

This study tests whether the drug belumosudil can prevent chronic graft-versus-host disease (cGVHD), a common complication after stem cell transplants where the donor's immune cells attack the patient's body. About 82 participants will receive either belumosudil or a placebo. The…

This study tests whether reducing the dose of the drug linvoseltamab, once it starts working, can lower side effects while still controlling multiple myeloma that has returned or stopped responding to other treatments. About 30 adults with relapsed or refractory myeloma will rece…

This study compares a new smartphone app called IndigeQuit to an existing app (NCI QuitGuide) to help American Indian and Alaska Native adults quit smoking. About 776 participants who smoke daily and want to quit in the next 30 days will be randomly assigned to use one of the app…

This study tests a stem cell transplant from half-matched (haploidentical) donors for people with various blood cancers. Before the transplant, patients receive chemotherapy and low-dose radiation to prepare the body. The goal is to see if this approach helps control the cancer a…

This study tests a combination of two drugs, acalabrutinib and venetoclax, in people whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has returned or not responded to prior therapy. The goal is to see if the combination can kill more cancer cells and a…

This study tests a radioactive antibody (211At-BC8-B10) followed by a donor stem cell transplant for people with high-risk leukemia or myelodysplastic syndrome (MDS) that has come back or not responded to treatment. The antibody targets cancer cells and delivers radiation, then c…

This study tests a new mix of two drugs (pralatrexate and bendamustine) plus low-dose total-body radiation before a donor stem cell transplant for people with T-cell lymphoma that has returned or not responded to treatment. The goal is to see if this approach is safe and helps mo…

This study tests a special cord blood transplant for people with high-risk blood cancers like leukemia and lymphoma. Participants receive chemotherapy and radiation before the transplant to kill cancer cells, then donor stem cells to rebuild healthy blood. After transplant, drugs…

This study tests whether the drug vorinostat can help men with a type of advanced prostate cancer that has low levels of a specific marker (PSMA). The marker is needed for a radioactive therapy called 177Lu-PSMA-617 to work. By giving vorinostat first, the hope is to increase PSM…

This early-phase trial tests a personalized cell therapy for people with metastatic solid tumors that have a specific genetic change called KRAS G12V. The patient's own immune cells are collected, genetically modified to recognize and attack the cancer, and then infused back. The…

This early-stage study tests a new treatment for children and adults whose acute leukemia has come back or not responded after a donor stem cell transplant. The treatment uses specially engineered immune cells (T cells) from the original donor that are trained to recognize and at…

This study tests a treatment plan for adults aged 60 and older with newly diagnosed, high-risk acute myeloid leukemia (AML) or similar blood cancers. The plan combines strong chemotherapy (FLAG-Ida) with a donor stem cell transplant shortly after, aiming to shorten the dangerous …

This study tests whether giving antibody replacements can prevent serious infections in people who have received CAR-T therapy for blood cancers. CAR-T therapy often lowers the body's natural antibodies, raising infection risk. The trial will compare antibody replacement to a pla…

This study tests a new treatment sequence for adults with aggressive blood cancers (like AML, MDS, or CMML) that are likely to return after standard therapy. Participants receive a combination of chemotherapy drugs (decitabine plus FLAG-Ida) followed by low-dose radiation and a d…

This study tests whether a dental cleaning shortly after a stem cell transplant can prevent chronic graft-versus-host disease (GVHD), a serious condition where donor cells attack the patient's body. Researchers think bacteria in dental plaque may trigger GVHD. The trial will enro…

This study tests a cooking program to help people in southern New Mexico eat healthier and lower their risk of cancer. Researchers will enroll 80 adults to learn practical cooking skills and nutrition tips. The goal is to see if the program is practical and liked by participants,…

This study tests whether eating only during an 8-hour window each day (time-restricted eating) can improve how well cancer treatments work and reduce side effects. It will enroll 100 Alaska Native or American Indian adults with rectal or breast cancer who are about to start treat…

This study looks at whether moderate-to-vigorous exercise can change the bacteria in the gut of people who have had stage II or III colorectal cancer. Researchers want to see if these changes might help improve cancer outcomes. The study involves 30 participants and focuses on wh…

This study tests a workshop called HOPE-C, designed to reduce burnout among doctors, nurses, and social workers who care for ovarian cancer patients. The workshop helps clinicians share their challenging experiences and build peer support. Researchers will enroll 25 clinicians to…

This study looks at whether patient navigation services, an interactive website, or both can help people who had stage I-III colorectal cancer get the recommended follow-up tests after surgery. These tests are important to catch any return of cancer early. About 75 survivors will…

This study looks at whether a patient navigator or a website (or both) can help people who have had a stem cell transplant for blood cancer plan their future medical care. About 40 adults who are 1 to 5 years post-transplant will take part. The goal is to see if these tools help …

This study tests a mobile app called PACT that helps people with advanced cancer talk about and plan the care they would want if they couldn't speak for themselves. About 400 patients and their support persons will use the app and report how easy and helpful it is. The goal is to…

This study looks at whether it's possible for people getting donor stem cell transplants for blood cancers to take daily fiber supplements. These patients often have mouth and gut damage from treatment, which can make eating hard. The goal is to see if fiber can support nutrition…

This study looks at how to help people in Zimbabwe who have both HIV and cancer stay connected to their HIV care while they get cancer treatment. Researchers will first track barriers and disruptions to HIV care in 150 patients, then create and test strategies to improve care eng…