Centre Hospitalier Universitaire Dijon

This study is testing whether a drug called alpelisib can help patients with MCAP syndrome, a rare genetic disorder that causes brain overgrowth, intellectual disability, and other health problems. For the first 6 months, some participants will receive the drug and others a place…

This study is testing whether a three-drug chemotherapy combination called mFOLFIRINOX works better than the current standard treatment for an aggressive, fast-spreading type of neuroendocrine cancer that has spread to other parts of the body. Researchers will enroll 218 adults w…

This study is testing a new approach for patients with a severe lung injury called focal ARDS who are on a breathing machine. Researchers want to see if using lung ultrasound to guide personalized ventilator settings can help patients breathe on their own sooner. They will compar…

This study is testing if a weekly injection called semaglutide can help adults who have features of both type 1 and type 2 diabetes, a condition sometimes called 'double diabetes.' The goal is to see if the drug can make the body respond better to insulin and improve blood sugar …

This study is testing whether a drug called lithium carbonate can help improve daily living skills and behavior in people with a rare genetic condition called TBR1-related neurocognitive disorder. The trial will involve about 12 participants, aged 6 and older, who have a confirme…

This study is testing small wearable sensors placed in shoes and on the body to measure how children walk. Researchers want to see if these sensors are as accurate as the bulky lab equipment currently used. The goal is to create a simpler way to track walking patterns in children…

This study aims to see if a special heart MRI scan can help doctors decide which stroke patients need a small implanted heart monitor. After a stroke with no clear cause, patients often get a monitor implanted under the skin to check for a hidden irregular heartbeat. Researchers …

This study is testing if a simple bedside ultrasound scan can identify which ICU patients on breathing machines are at risk for swallowing problems after the breathing tube is removed. Swallowing issues can lead to serious lung infections and longer hospital stays. Researchers wi…

This study is testing a new smartphone app designed to measure movement in children with cerebral palsy. Researchers want to see if the app is as accurate as expensive, lab-based systems at tracking tasks like jumping and running. The goal is to create an easier, more accessible …

This study aims to find the most accurate blood test to detect diabetes in people who need to take steroid medications long-term. It will enroll 75 non-diabetic adults starting a steroid treatment plan lasting more than three months. Researchers will compare several common blood …

This study aims to help patients with rare developmental abnormalities who have been unable to get a clear diagnosis, often for years. Researchers will re-examine old genetic test results using newer technology and offer advanced genetic testing to try to find answers. The goal i…

This study is testing a new blood marker called hPG80 to see if it can help find neuroendocrine tumors earlier in people with a rare inherited condition called MEN1. Currently, people with MEN1 need frequent, stressful scans and tests to check for these tumors. The goal is to see…

This study is testing whether a blood test measuring a protein called thrombomodulin can accurately tell which patients with polymyalgia rheumatica (PMR) also have a more serious condition called giant cell arteritis (GCA). Researchers will enroll 78 adults over 50 with PMR to se…

This study is testing a newer, more detailed type of genetic test to find the cause of cerebellar ataxia, a rare brain disorder that affects movement. It focuses on patients whose condition remains unexplained after standard genetic testing. Researchers hope this advanced test ca…

This study is testing if a quick, non-invasive eye scan can help diagnose microvascular angina, a common but hard-to-detect heart condition. Researchers will compare the eye scan results of 158 people who have already had a more invasive heart test for the condition. The goal is …

This study is testing whether taking preventive blood thinners for 12 weeks can stop dangerous blood clots from forming in people with autoimmune hemolytic anemia (AIHA), a rare blood disorder. It will involve 72 adults who are newly diagnosed or having a relapse of AIHA. Partici…

This study is testing if a non-antibiotic treatment called OM-89 can prevent urinary tract infections (UTIs) in adults with spinal cord injury who use a catheter. The goal is to see if OM-89 reduces how often participants need antibiotics for UTIs over one year. About 110 people …

This study is testing whether an infotainment system (like movies or music) can help people who feel unexpectedly anxious about getting an MRI scan. Researchers will compare this entertainment approach to standard care to see if it helps more patients complete their brain MRI. Th…

This study is testing if adding 'motor imagery'—mentally practicing movements without physically doing them—to a standard back pain rehab program helps people feel better. It will involve 72 adults with long-term low back pain. Researchers want to see if this mental practice impr…

This study is testing if adding muscle vibration therapy to standard rehab can help reduce muscle stiffness (spasticity) and improve movement in people recovering from a recent stroke. Researchers will compare two groups: one gets standard rehab plus real vibrations, and the othe…

This study is exploring whether listening to music can help older adults with age-related hearing loss better understand complex sentences. Researchers will have 27 participants aged 70 and over listen to different types of music and then test their language skills. The goal is t…

This study aims to understand why people with depression have a much higher risk of heart disease. Researchers will compare blood samples from 90 adults—some with depression and some without—to analyze specific fats and proteins. The goal is to uncover biological links between de…

This study aims to understand how cancer and its treatments affect taste and smell, and how these changes lead to poor nutrition. Researchers will follow 306 newly diagnosed patients with specific cancers to identify early warning signs of undernutrition. The goal is to gather kn…

This study is testing a new method of screening newborns for rare genetic diseases using advanced DNA sequencing. It will enroll 5,000 newborns across five French hospitals to see if this screening process is practical, fast, and acceptable to parents. The goal is to gather infor…

This study aims to better understand the mechanical properties of the aorta in patients with thoracic aortic aneurysms who are scheduled for surgery. Researchers will analyze tissue samples collected during surgery and perform MRI scans to measure how the aorta stretches and move…

This study aims to find a better way to predict if patients in intensive care can safely receive extra IV fluids. Researchers will use ultrasound scans while briefly raising a patient's legs to see if changes in blood flow patterns can forecast fluid tolerance. The goal is to hel…

This study aims to better understand the heart and blood pressure risks linked to newer targeted cancer pills (acalabrutinib, zanubrutinib). Researchers will closely monitor 100 patients taking these drugs for one year to see how often these side effects occur and identify which …

This study aims to discover the genetic causes behind rare diseases that currently have no diagnosis. Researchers will use advanced DNA sequencing to analyze samples from 850 patients and family members with suspected genetic conditions. The goal is to identify new genes or genet…

This study aims to understand how certain fats (omega-3 fatty acids) and how the placenta processes them might be connected to an eye disease called retinopathy of prematurity (ROP) in very premature babies. Researchers will compare mothers who give birth very early (before 29 we…

This study aims to understand the causes of scleroderma by comparing skin cells from patients with the disease to cells from healthy volunteers. Researchers will analyze the genes in these cells to see how they differ. The goal is to learn more about what drives the disease, whic…

This study aims to understand if low blood sugar at night contributes to severe muscle loss in people with liver cirrhosis. Researchers will monitor 200 participants' blood sugar continuously and measure their muscle mass and strength. The goal is to gather evidence to design bet…

This study aims to find easier ways to measure walking problems in adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic muscle-wasting disease. Researchers will test if simple walking tests, like a 6-minute walk, give useful information compared to more complex, t…

This study aims to improve a standard blood test used to check how well platelets help form clots. Researchers will compare results from the usual blood collection tube with a newer type (BAPA tube) in 100 adults already scheduled for the test. The goal is to see if the new tube …

This study aims to understand how age-related changes in thinking skills, like memory, might affect a person's movement and balance. Researchers will observe and measure the motor skills of over 600 adults, including those over 55 with and without mild thinking problems. The goal…

This study aims to create a 'digital twin'—a personalized computer model—for patients with a chronic tear in their main heart artery (aortic dissection). The model combines blood flow, tissue mechanics, and blood markers to better predict if a dangerous bulge (aneurysm) will deve…

This study aims to understand how people with leg amputations prepare to walk on slopes and stairs. Researchers will use machine learning to analyze walking patterns in 70 participants, including healthy volunteers and amputees. The goal is to gather data to eventually create a s…

This study aims to understand how a person's socioeconomic status—like income, education, and social support—affects their recovery after a serious stay in the intensive care unit (ICU). Researchers will follow 180 patients and their family members in France to see if social and …

This study aims to better understand the mental health challenges faced by people with White-Sutton syndrome, a rare genetic disorder. Researchers will interview about 30 patients and their families to describe the types and frequency of psychiatric symptoms like anxiety, OCD, an…