Ultrasound-Guided ventilation may shorten time on ventilator for ARDS patients
NCT ID NCT04966624
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new ventilation strategy for patients with a specific type of acute respiratory distress syndrome (ARDS) called focal ARDS. The strategy uses lung ultrasound to guide ventilator settings, early prone positioning, and adjustments based on body mass index. The goal is to see if this approach reduces the number of days patients need a ventilator compared to standard care. The trial plans to enroll 84 adults who have been on a ventilator for less than 24 hours.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ventilation strategy using APRV mode, early prone sessions, and PEEP adjustment based on BMI
- What this could lead to
- If successful, this could reduce the number of days patients with focal ARDS need a ventilator, potentially improving recovery and reducing complications.
- What could go wrong
- This is a small, early-stage trial (84 participants) testing a bundle of measures. Previous similar research failed to show a survival benefit, and the approach may not work for all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 84 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2021
- Expected to finish
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Jul 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * person who has given oral consent or has been included in an emergency * Older than 18 years * On mechanical ventilation for less than 24 hours * Diagnosis of ARDS for less than 24 hours. ARDS according to the Berlin classification: i.e. arterial oxygen pressure to inspired oxygen fraction ratio less than or equal to 300, with a PEEP greater than or equal to 5, presence of bilateral radiological infiltrates not fully explained by heart failure or volume overload * Focal ARDS determined on pulmonary ultrasound Exclusion Criteria: * person who is not a beneficiary of national health insurance * person who is subject to a legal measure of protection (curatorship, guardianship) * pregnant or breastfeeding women * minor * Patient having benefited from an invasive mechanical ventilation of more than one week in the previous month; * ARDS in the previous month; * Chronic respiratory failure under NIV or long term oxygen; * Severe acute asthma; * Lobectomy; * Pneumothorax; * Pneumomediastinum; * Pulmonary fibrosis; * Morbid obesity with a BMI above 40 ; * Cancer with metastasis; * Bone marrow transplantation; * Chemotherapy-induced neutropenia; * Cirrhosis with a Child-Pugh score of C; * Suspected or confirmed intracranial hypertension; * Concurrent participation in another ARDS study; * Extensive burns on the torso.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Chu Dijon Bourgogne
RECRUITINGDijon, 21000, France