Centre Hospitalier Universitaire Dijon

This study tests a drug called alpelisib in 20 people aged 2 to 40 with MCAP syndrome, a rare condition causing an enlarged brain and developmental delays. The goal is to see if the drug improves daily living skills, communication, and social abilities over 6 months compared to a…

This study looks at people with stage III colorectal cancer who have completed surgery and standard chemotherapy. A blood test checks for tiny bits of cancer DNA (ctDNA) that might mean some cancer cells remain. Those with positive ctDNA are randomly assigned to either get extra …

This study tests whether a chemotherapy regimen called FOLFIRINOX works better than the standard platinum-etoposide combination for people with advanced, fast-growing neuroendocrine cancer of the digestive system or unknown origin. About 218 participants will receive one of the t…

This study tests a new breathing strategy for patients with a specific type of lung injury called focal ARDS. The strategy uses lung ultrasound to guide ventilator settings and includes techniques like allowing some spontaneous breathing and early prone positioning. The goal is t…

This study tests a weekly injection of semaglutide (a GLP1 drug) in 76 adults who have 'double diabetes' — type 1 diabetes plus inherited insulin resistance like type 2. The goal is to see if the drug helps them spend more time with healthy blood sugar levels. Participants must b…

This study tests whether OM-89, an extract from E. coli bacteria, can reduce the number of antibiotic treatments needed for urinary tract infections in adults with neurogenic bladder who use catheters. Participants will receive either OM-89 or a placebo for one year. The goal is …

This study tests whether adding argipressin to standard norepinephrine treatment helps people in intensive care with severe vasoplegic shock (a type of shock where blood vessels widen dangerously). About 390 adults will be randomly assigned to get argipressin or a placebo alongsi…

This study is testing whether a blood test for a protein called hPG80 can help detect neuroendocrine tumors (NETs) earlier in people with MEN1, a rare genetic condition that raises tumor risk. About 297 participants with MEN1 will give blood samples, which will be compared to sta…

This study aims to find the most effective way to screen for diabetes in people who take glucocorticoids (steroids) for more than three months. Steroids can raise blood sugar and cause diabetes, but current screening methods vary. Researchers will compare three tests—fasting bloo…

This study looks at whether measuring a protein called thrombomodulin in the blood can help doctors know if a person with polymyalgia rheumatica (PMR) also has giant cell arteritis (GCA), a more serious condition that can cause blindness or stroke. About 78 adults over age 50 wit…

This study tests a new DNA sequencing method (long-read) to find genetic causes of cerebellar ataxia in 210 people who had no diagnosis from standard tests. Participants and up to two family members provide samples. The goal is to see if this advanced technique can identify hidde…

This study aims to help people with developmental abnormalities who have not yet received a clear genetic diagnosis. Researchers will look back at past cases and also offer new, advanced genetic testing (including genome and RNA analysis) to find answers. The goal is to reduce th…

This study is testing a new device that acts like a tiny blood vessel to measure how well a person's blood can stop bleeding. Researchers want to see if it can better identify bleeding risk in people with von Willebrand disease, platelet disorders, or those taking antiplatelet dr…

This study tests whether taking a blood thinner (apixaban) for 12 weeks can prevent dangerous blood clots in people with autoimmune hemolytic anemia (AIHA), a rare disease where the immune system destroys red blood cells. About 72 adults with newly diagnosed or relapsed AIHA will…

This study tests whether gentle muscle vibration can prevent or reduce muscle stiffness (spasticity) in people who recently had a stroke. Researchers will compare usual rehab plus vibration to usual rehab plus a placebo vibration in 100 early-stage stroke patients. The goal is to…

This study tests whether adding motor imagery (mentally practicing movements without actually moving) to a standard 3-week rehab program helps people with chronic low back pain. About 72 adults with pain lasting over 6 months will participate. The goal is to see if this technique…

This study tests whether virtual reality (VR) therapy can improve movement and balance in elderly people with psychomotor disadaptation syndrome, a condition that makes walking and daily activities difficult. Fifty hospitalized patients aged 65 and older will receive either stand…

This study tests if lithium carbonate can improve behavior and thinking in people with a rare genetic disorder caused by changes in the TBR1 gene. The disorder often leads to developmental delays, intellectual disability, and autism-like traits. Twelve participants aged 6 and old…

This study is testing a new smartphone app called eMind that teaches mindfulness to help people stop smoking. The app is designed to be used for 8 weeks, just like an in-person program. Researchers want to see if smokers find the app easy and helpful to use. 40 adults who smoke a…

This study explores whether listening to rhythmic music can improve the language abilities of older adults (70+) with age-related hearing loss. Researchers will compare the effects of rhythmic versus non-rhythmic music on syntax skills. The goal is to find a simple, non-invasive …

This study tests if using an infotainment system (like a TV or music) during an MRI scan can help people who feel unexpectedly anxious. Researchers will compare two ways of caring for these patients to see which leads to better quality brain images. The goal is to help anxious in…

This study tests whether a non-invasive brain stimulation technique called tDCS can help people who have lost control over their internet gaming. About 50 participants aged 12 and older will receive five sessions of tDCS, and researchers will track changes in gaming behavior over…

This study aims to find new genes or genetic changes that cause rare diseases. Researchers will study up to 850 people, including patients with suspected genetic rare diseases, fetuses with developmental issues, and healthy relatives. By using advanced DNA sequencing, they hope t…

This study looks at skin cells called fibroblasts from people with scleroderma and compares them to cells from healthy volunteers. The goal is to find which genes are turned on or off in these cells, especially those linked to aging and inflammation. By understanding these differ…

This study looks at why some premature babies develop an eye problem called retinopathy of prematurity (ROP). Researchers think that fatty acids from the mother may play a role. They will measure fatty acid receptors in the placenta and compare them between mothers of premature a…

This study looks at how age-related changes in thinking skills (like memory) affect movement and increase fall risk. Researchers will compare healthy younger adults, healthy older adults, and older adults with mild memory problems. The goal is to find new ways to prevent falls an…

This study looks at how a person's income, job, and social support affect their recovery after a serious illness in the intensive care unit (ICU). Researchers will follow 180 patients and their families to see who develops Post-Intensive Care Syndrome (PICS), which includes physi…

This study aims to understand why people with depression have a higher risk of heart attacks. Researchers will analyze the function and composition of HDL ("good") cholesterol in 90 adults with depression compared to healthy controls. The goal is to uncover how depression may aff…

This study is testing whether it is possible and acceptable to use genome sequencing to screen newborns for rare diseases in France. Researchers will offer the test to parents of 5000 newborns across five hospitals. The goal is to see how many families agree to the screening and …

This study looks at 100 people who had a stroke with no clear cause. They will get a heart MRI to measure scar tissue in the left atrium, which might lead to atrial fibrillation. The goal is to see if the MRI can predict who will develop atrial fibrillation, so doctors can better…

This study is testing whether a smartphone app can accurately measure how children with cerebral palsy move, like jumping and walking. Researchers want to see if the app works as well as expensive lab equipment, so kids can be assessed at home or school. About 60 children aged 6 …

This study looks at how people with lower limb amputations adjust their walking when going up or down slopes and stairs. Researchers will use machine learning to analyze movement patterns in 70 participants (including healthy volunteers). The goal is to design smarter prosthetic …

This study looks at whether low blood sugar during the night is connected to muscle loss (sarcopenia) in people with cirrhosis. Researchers will monitor 200 adults with cirrhosis using a continuous glucose monitor and measure muscle mass and strength. The goal is to gather data t…

This study looks at whether improving blood sugar control in people with type 1 diabetes can restore the function of their 'good' HDL cholesterol to normal levels. Researchers will compare 80 patients with poorly controlled diabetes who receive intensified therapy to 63 healthy v…

This study tests small, wearable motion sensors (IMUs) to measure walking in healthy children and children with cerebral palsy. The goal is to see if these sensors can accurately track walking speed and movement in real-life settings, unlike current lab-based systems. 80 children…

This study follows 100 adults with blood cancers who are taking newer targeted drugs called second-generation BTK inhibitors (acalabrutinib or zanubrutinib). The goal is to track how often heart problems like high blood pressure and irregular heartbeat occur, and to find out whic…

This study looks at how cancer and its treatments change a person's sense of taste and smell, and how that affects their eating habits and nutrition. Researchers will follow 306 people newly diagnosed with mouth, throat, colon, or liver cancer to understand these links. The goal …

This study looks at whether quick, easy walking tests can effectively measure mobility problems in adults with facioscapulohumeral muscular dystrophy (FSH), a genetic muscle disease that often causes walking difficulties. Researchers will compare these simple tests with the stand…

This study aims to learn more about the biomechanical properties of the aorta in 200 patients who need surgery for an ascending aortic aneurysm. Researchers will use MRI scans before surgery and test the removed aortic tissue in the lab. The goal is to better understand the aorta…

This study looks at psychiatric symptoms in people with White-Sutton syndrome, a rare genetic disorder that can cause developmental delays and other health issues. Researchers want to better understand common mental health problems like anxiety, autism, and attention disorders in…

This study looks at whether a simple leg-raising test, combined with ultrasound, can help doctors predict how well ICU patients will handle extra fluids. Giving too much fluid can cause harm, so finding a better way to guide treatment is important. The study will involve 100 adul…

This study aims to create a digital twin—a computer model—for people with chronic aortic dissection, a tear in the aorta wall. The model will combine imaging, blood flow, and other factors to better predict if an aneurysm will form and need surgery. Researchers will enroll 400 ad…