Cedars-sinai Medical Center

This early-stage study tests whether atezolizumab, a drug used for cancer, is safe for people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring. About 24 adults aged 50 and older with confirmed IPF will receive the drug. Researchers will track side eff…

This study looks at whether a lower-dose version of standard chemo-radiation can work just as well for people with HPV-positive throat cancer after robotic surgery, while causing fewer side effects. About 40 patients who have had or will have surgery to remove their cancer will r…

This study looks at whether terazosin, a drug usually used for high blood pressure, can slow the progression of Parkinson's disease. Researchers will track changes in heart and brain scans over three years in 15 people with early signs of Parkinson's or a sleep disorder that rais…

This study tests a program to help older adults (65+) safely reduce or stop unnecessary medications that may cause side effects. Researchers will use a risk prediction tool to identify 100 participants and compare those who receive the deprescribing program to those who don't. Th…

This study looks at whether women aged 65 and older with early-stage, estrogen-positive breast cancer can safely skip sentinel node biopsy (a procedure to check lymph nodes) when having a lumpectomy. The goal is to see if skipping this step leads to cancer coming back in the lymp…

This study tests whether adding the drug Thymoglobulin to standard anti-rejection medicines can prevent heart transplant complications. About 60 people receiving their first heart transplant will take part. Half will get Thymoglobulin for 5 days after surgery, and all will be mon…

This study tests whether a pharmacist-led medication review before and after hospital discharge can reduce the number of patients who need to return to the hospital or visit the ER within 30 days. It involves over 6,000 older adults (55+) who take many medications or specific hig…

This study is testing a new urine test that looks for specific proteins to detect bladder cancer in 450 people who have blood in their urine. The goal is to see if this simple, non-invasive test can accurately identify cancer, potentially reducing the need for a camera exam calle…

This study is testing a new urine test that looks for specific markers of bladder cancer. The goal is to catch the disease early in people at high risk, such as those over 50 with a heavy smoking history. Researchers will follow 173 participants for up to 4 years to see how accur…

This early-stage study tests whether injecting donated fat tissue (allograft adipose matrix) into the small joints of the hand can safely reduce pain and improve movement in people with early hand osteoarthritis. About 34 adults with joint pain and X-ray evidence of arthritis wil…

This study compares two methods of giving the pain medicine EXPAREL during knee replacement surgery to see if they provide the same amount of pain relief. About 40 adults having knee replacement will receive EXPAREL either as a targeted block or as local infiltration. Participant…

This early-phase study tests giving focused radiation to brain tumors before surgical removal, aiming to protect healthy brain tissue and possibly eliminate the need for radiation after surgery. About 25 adults with brain metastases (tumors that spread from other cancers) will re…

This study tests a culturally tailored mobile health program for 150 Black pregnant women to see if it reduces symptoms of depression, anxiety, and stress. Half of the participants receive the app, which teaches communication and self-advocacy skills and offers a support network.…

This study looks at whether a supervised exercise program is safe and practical for people with pancreatic cancer. Sixteen participants will attend exercise sessions before their main treatment. The goal is to see if at least half of them can stick with the program, and to check …

This study looks at how carvedilol, a drug used for heart conditions, affects brain scans in people who may be in the very early stages of Parkinson's disease. Researchers are following 15 participants with certain risk factors, like REM sleep behavior disorder, for three years t…

This study looks at whether terazosin, a drug used for high blood pressure, can change heart nerve activity in people with REM sleep behavior disorder (a strong early sign of Parkinson's). Researchers will measure heart scans and symptoms over 26 weeks in 15 adults aged 50-85. Th…

This study looks at 433 women who have chest pain but no major blockages in their heart arteries. Researchers want to see if a special MRI scan can detect small artery problems that standard tests miss. Participants get both a standard angiogram and a cardiac MRI, and are followe…

This study looks at how the brain learns, remembers, and makes decisions by recording brain activity in 200 people with epilepsy who are already undergoing monitoring. Participants perform simple computer tasks while researchers measure their brain signals. The goal is to better …

This study explores whether a new type of MRI (6D-MRI) can predict how well treatment works in people with pancreatic cancer. Researchers will scan 36 patients before and during chemotherapy to see if the images can forecast cancer progression and surgical success. The study is c…

This study tests a new high-density microelectrode designed to record the activity of individual nerve cells in the brain. Researchers will compare its performance and safety to standard electrodes in 10 people with Parkinson's disease who are already scheduled for deep brain sti…