Cedars-sinai Medical Center

This study compares two ways to keep donor hearts cold during transport for heart transplants. The new adjustable cooler aims to be more precise, cheaper, and less wasteful than the current standard device. Researchers will check if it reduces early heart problems after transplan…

This study tests whether mirabegron, a drug usually used for overactive bladder, can reduce dangerous heart rhythms in people with heart disease. Twenty adults with an implanted defibrillator and frequent ventricular tachycardia will take the drug for two months. Researchers will…

This study looks at whether a special 5-day fasting-mimicking diet each month for 6 months is safe and can improve blood flow to the brain in 40 middle-aged adults (45-65) who carry the APOE4 gene, which raises Alzheimer's risk. Participants will be randomly assigned to either th…

This study looks at whether early visits to a heart specialist (cardio-oncologist) can help lower heart risks in men with advanced prostate cancer who are taking hormone therapy. About 80 men aged 45 and older with heart risk factors will be enrolled. The goal is to see if starti…

This pilot study tests whether giving people the choice between two weight management strategies—avoiding tempting foods or resisting them—helps them stick to their plan better than being assigned a strategy. Researchers will enroll 60 adults with overweight or obesity to compare…

This study compares two standard treatments for severe narrowing of the heart's aortic valve in people born with a bicuspid (two-flap) valve. One treatment is a minimally invasive procedure (TAVR), the other is open-heart surgery (SAVR). The goal is to see which approach is safer…

This study tests whether taking S-adenosylmethionine (SAMe), a natural supplement, can prevent liver injury caused by the chemotherapy drug oxaliplatin in people with colorectal cancer that has spread to the liver. About 30 adults with resectable liver tumors will take SAMe pills…

This study tests whether a natural supplement called SAMe can help prevent liver cancer in people with advanced fatty liver disease (MASLD) and cirrhosis. About 94 adults will receive either SAMe or a placebo for 12 months. Researchers will measure changes in a blood test that pr…

This study tests a 2-hour online class called Empowered Relief for 100 adults with advanced osteoarthritis who cannot have joint replacement surgery. The class teaches simple pain management skills based on cognitive behavioral therapy and mindfulness. Researchers will measure pa…

This study tests whether mirabegron, a drug already used for overactive bladder, can reduce symptoms of Postural Orthostatic Tachycardia Syndrome (POTS), a condition that causes a rapid heartbeat upon standing. About 36 adults with confirmed POTS will receive either the drug or a…

This study compares two types of virtual reality—an interactive puzzle game versus calming scenery—to see which better reduces pain and anxiety during common in-office ENT procedures like sinus surgery or vocal cord injections. About 132 adults will wear a VR headset during their…

This study tests whether using a virtual reality (VR) headset at home can help adults with chronic pancreatitis manage their ongoing abdominal pain. Twenty participants will use a special VR program designed to focus on the gut, along with a Fitbit to track activity. The main goa…

This study tests if spraying a numbing medicine (bupivacaine with epinephrine) over the diaphragm can reduce shoulder pain after laparoscopic gynecologic surgery. About 100 women will receive either the numbing spray or a saltwater spray during surgery. Researchers will compare p…

This study tests a bilingual online peer-support program for Korean-speaking breast cancer survivors and patients. Survivors act as mentors to current patients over 12 weeks. The goal is to see if the program is easy to use and improves quality of life, mood, and social support.

This study looks at how the brain uses past experiences to make decisions in new situations. Researchers will monitor brain activity in 114 adults with epilepsy who are already undergoing brain monitoring. Participants will perform simple computer tasks to help scientists underst…

This study tests whether a digital inhaler can help people with chronic lung disease (COPD) manage their condition better. Researchers will see if patients are willing to use the smart inhaler and stick with it for 6 months. The goal is to reduce hospital visits and improve sympt…