Cedars-sinai Medical Center

This study tests a 4-week course of an oral drug called seliciclib in 13 adults with Cushing disease. The goal is to see if it can lower high cortisol levels safely. Participants may have newly diagnosed, persistent, or recurrent disease.

This study tests whether a strict ketogenic diet (high fat, low carb) can help people with a new diagnosis of glioblastoma, an aggressive brain cancer, live longer. About 170 participants will be randomly assigned to either the keto diet or standard dietary advice, while all rece…

This study tests whether adding the drug ivonescimab to standard chemotherapy before surgery can improve outcomes for people with early-stage triple-negative breast cancer. About 34 participants will receive the combination every three weeks for six cycles, then undergo surgery t…

This study compares two ways to help people with overweight or obesity lose weight: avoiding tempting situations (AVOID) or practicing self-control when faced with cravings (RESIST). About 500 adults will be followed for 12 months to see which approach works better for weight los…

This study tests whether intensive cholesterol-lowering therapy can increase immune cells (CD8+ T cells) in the prostate of men with prostate cancer who are on active surveillance. About 140 participants will take a combination cholesterol drug (Vytorin or ezetimibe) for 3-6 mont…

This study tests whether a stem cell transplant using the patient's own cells can 'reset' the immune system in teens and young adults (ages 13-28) with severe Crohn's disease that hasn't responded to other treatments. The approach removes overactive immune cells and replaces them…

This study is testing a new urine test that looks for specific proteins to detect bladder cancer in people who have tiny amounts of blood in their urine (microscopic hematuria). The goal is to see if this simple, non-invasive test can accurately identify bladder cancer, potential…

This study is testing a new urine test that aims to predict whether bladder cancer patients will respond well to a standard treatment called BCG. About 400 adults with intermediate or high-risk non-muscle invasive bladder cancer will provide urine samples before starting BCG ther…

This study aims to see if a new urine test can accurately detect bladder cancer recurrence in 300 people with a history of the disease. Currently, patients need a camera inserted into the bladder (cystoscopy) to check for cancer return. If successful, this simple urine test could…

This study tests whether a dye called CYTALUX™, given before surgery, can help surgeons see cancer tissue in real time using a special camera. It includes 15 adults with stomach, esophagus, or appendix cancer who are already scheduled for surgery. The goal is to see if this techn…

This study tests a decision aid called Protect Your Colon™ to see if it helps people aged 45-75 who are due for colorectal cancer screening choose and complete a screening test. About 184 participants will either use the tool or get usual care. The goal is to increase screening u…

This study tests whether daily 15-minute virtual reality sessions with calming nature scenes and meditation can prevent delirium in ICU patients. About 822 high-risk adults in the surgical ICU will either get standard care or standard care plus VR. The goal is to see if this drug…

This study tests whether adding hands-on nutrition demonstrations helps people at risk for prediabetes stay in the Diabetes Prevention Program. About 20 adults who are eligible for the program will take part. The goal is to see if this approach improves participation and health h…

This study tests whether smelling lavender during awake ear, nose, and throat procedures can lower anxiety and pain. About 184 adults will be randomly assigned to receive either lavender aromatherapy or an odorless placebo during their procedure. Participants will fill out short …

This study tests if shining a special light on the forehead (called photobiomodulation) can improve thinking skills in people with mild memory loss or early Alzheimer's. Researchers will give the light treatment and then check memory, attention, and blood markers. The goal is to …

This study tests whether a special discharge program for continuous glucose monitors (CGMs) can improve satisfaction and quality of life in adults with diabetes who use insulin. About 37 participants will complete surveys before and after using the device. The goal is to see if b…

This study looks at whether a low dose of oral ketamine can help reduce anxiety in people with pancreatic cancer. About 20 participants will receive either ketamine or a placebo in a crossover design, meaning everyone gets both treatments at different times. The main goal is to s…

This study tests a one-time, 30-minute financial education session for people with gynecologic cancer and their caregivers. The goal is to see if the program is practical and helps patients feel more confident and less stressed about the costs of cancer care. About 36 participant…

This study tests whether taking zinc and nicotinamide riboside (a form of vitamin B3) twice a day for 24 weeks can improve symptoms and quality of life in people with idiopathic pulmonary fibrosis (IPF), a serious lung disease. The trial is designed to be done mostly from home, w…

This study tests whether using a navigation system during balloon sinus dilation improves success rates for people with chronic maxillary sinusitis. About 50 adults who have not had prior sinus surgery and have not improved with medication will take part. The goal is to see if na…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve daily life in people with digestive tract cancers. 360 participants will be randomly assigned to one of three groups: skills-based VR, distraction VR, or a sham VR. The goal is to see if …

This pilot study tests whether simvastatin, a common cholesterol medication, can improve quality of life in adults with recurrent acute or chronic pancreatitis. Researchers will enroll 90 participants to see if the treatment is feasible and acceptable. The goal is to reduce sympt…

This study looks at whether providing medically tailored meals and shakes for 12 days after orthopedic trauma surgery can improve healing and nutrition. About 75 adults who live in certain Los Angeles zip codes will receive the meals at home through Meals on Wheels. Researchers w…

This early study tests whether a vitamin D-like drug called paricalcitol can improve quality of life for people with chronic pancreatitis. About 24 adults will take the drug or a placebo for 12 months. Researchers will check if the treatment is practical and acceptable, and measu…

This study looks at whether wearing a small splint at night after a cortisone injection can improve pain and hand function for people with trigger finger. About 146 adults will be split into two groups: one gets the injection plus the night splint, the other gets only the injecti…

This study tests whether a new nasal spray device that delivers fluticasone deeper into the nose can improve symptoms of Eustachian tube dysfunction, a condition that causes ear pressure, popping, and muffled hearing. About 80 adults with chronic symptoms will receive either the …

This study aims to help pregnant individuals who used assisted reproductive technology (ART) build a strong coparenting bond with a support person. Participants will attend 9 virtual sessions and complete surveys and at-home blood tests to measure stress and inflammation. The goa…

This study tests whether a digital platform called VirtuaCare can help people with shoulder problems do their exercises at home instead of going to the clinic as often. Researchers want to see if using the app leads to better recovery and fewer in-person visits. The study involve…

This study tests if limiting when you eat (time-restricted eating) can reduce side effects from cancer treatment, improve mood, and even affect tumor biology. Researchers will enroll 175 adults with rectal or breast cancer who are receiving treatment. Participants will follow a s…

This study compares different pain treatment options for transgender people after gender-affirming surgery. The goal is to find which methods work best to control pain while reducing the need for opioids and their side effects. Researchers will track pain levels, opioid use, and …

This study looks at how two different ablation catheters affect the temperature of the esophagus and the risk of injury during treatment for atrial fibrillation. About 30 adults with paroxysmal AFib will be enrolled. The goal is to find which approach is safer for the esophagus.

This study follows 1,250 people with pituitary tumors over time to learn what predicts tumor return and ongoing disease. No new treatments are tested; researchers simply track health outcomes using medical records. The goal is to better understand the disease, not to treat it dir…

This study looks at whether it is safe to monitor small thyroid cancers (1.5 cm or smaller) instead of removing them right away. About 216 people with papillary thyroid microcarcinoma will be followed to see how often the disease progresses. The goal is to learn which patients ca…

This study tests whether giving doctors AI-powered feedback on how they discuss prostate cancer risks helps patients make more informed decisions. About 259 men with early-stage prostate cancer and 24 doctors will take part. The goal is to see if this feedback reduces confusion a…

This study looks at fat tissue from older adults to see how cells change with age and obesity. Researchers will take small fat samples and use advanced techniques to map different cell types. Some older participants will also try lifestyle changes or a drug that targets aging cel…

This study compares a new capillary-action catheter to the standard tool for collecting fluid from the small intestine during an upper endoscopy. The goal is to see if the new device can collect samples faster and with more volume, which could help diagnose conditions like SIBO (…