TYPE 2 DIABETES MELLITUS (T2DM)

This study tests an experimental drug called MKP10241 in 68 adults who are obese, with or without type 2 diabetes. The main goals are to check how food affects the drug, how it moves through the body, and whether it is safe. Participants will take different doses of the drug or a…

This study tests a program called 'Disfrutando' designed to help people with type 2 diabetes, especially those facing social challenges like food or housing insecurity. The program teaches practical self-management skills and addresses barriers to healthy living. About 31 adults …

This study tests a 12-week exercise program for adults aged 45 to 85 who have both type 2 diabetes and sarcopenia (age-related muscle loss). The program combines supervised and home-based exercises with digital support to improve muscle function, physical performance, and blood s…

This study looks at whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages can help them become more active and better manage their condition. Researchers will enroll 36 adults who are not very active. Participants will wear a Fitbit and r…

This study tests whether replacing regular starchy foods with quinoa products (like noodles and cookies) for 14 weeks can improve blood sugar control, reduce cholesterol, and stabilize glucose swings in people with early type 2 diabetes. Sixty adults aged 20-70 with diabetes for …

This study looks at whether using a para-probiotic toothpaste and mouthwash can improve gum health and blood sugar control in adults with type 2 diabetes and gum disease. Forty participants will receive standard gum treatment and then use either the probiotic products or a standa…

This study tests a program to help doctors better screen and treat chronic kidney disease (CKD) in adults with type 2 diabetes. About 420 participants will receive care through their primary doctor, with the goal of increasing use of recommended medications. The program focuses o…

This study tests whether providing healthy groceries and lifestyle coaching can help adults with high blood pressure and type 2 diabetes who live in areas with limited access to healthy food. About 80 participants from Baltimore will be randomly assigned to receive either standar…

This study in Pokhara, Nepal, will test if female community health volunteers visiting homes and sending regular SMS messages can help people better manage high blood pressure, type 2 diabetes, and quit smoking. About 2,070 adults with these conditions will be split into two grou…

This study looks at whether meals designed for a person's ethnic background can improve blood sugar control in adults with type 2 diabetes. About 30 Asian Indian or Filipino participants will wear a continuous glucose monitor for one month while eating their usual diet and then s…

This study tests whether a weekly semaglutide injection works better than a calorie-restricted diet for people with type 2 diabetes and fatty liver disease. Over 12 weeks, researchers will measure changes in blood sugar, weight, inflammation, and liver fat. The goal is to find th…

This study tests whether a 12-week multimodal exercise program can improve physical performance and muscle function in middle-aged adults (45-64 years) with type 2 diabetes. 66 participants will be randomly assigned to either receive standard care or join the exercise program. Th…

This study tests whether a new combination of diabetes drugs can help people with type 2 diabetes achieve more stable blood sugar levels. About 178 adults whose blood sugar is not well controlled with metformin and an SGLT-2 inhibitor will receive the study treatment for 12 weeks…

This study tests whether starting two diabetes drugs early—metformin plus either oral semaglutide or empagliflozin—works better than metformin alone for controlling blood sugar in people recently diagnosed with type 2 diabetes. About 90 adults with diabetes for up to 2 years will…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce these health risks. About 200 adults with HIV who are patients at a North Carolina clin…

This study tests a new medicine called ALN-4324 in two groups: first in healthy overweight volunteers to check safety, then in overweight adults with type 2 diabetes to see if it helps control blood sugar. The study is early-stage and focuses on safety and how the drug works in t…

This study tests whether giving people with type 2 diabetes a continuous glucose monitor and a smart insulin pen cap at hospital discharge helps them stick to their insulin schedule and control blood sugar better. About 80 adults who start insulin while in the hospital will be sp…

This study tests whether personalized marketing and discounts in an online grocery store can encourage people with prediabetes or type 2 diabetes to buy more whole grains instead of refined grains. About 216 adults aged 45-70 from Pennsylvania who already shop online for grocerie…

This study tests whether breathing a special mix of low and high oxygen air (called IHHT) for 3 or 10 days can help control blood sugar in people with type 2 diabetes, including older adults. About 250 participants aged 50-74 will be randomly assigned to short or long treatment o…

This study tests whether a single dose of the experimental drug ALN-4324 can improve how the body responds to insulin in people with type 2 diabetes. About 40 adults on stable metformin therapy will receive either the drug or a placebo. The main goal is to measure changes in insu…

This study tests a new surgical device (a clip) to treat type 2 diabetes and obesity in people with a BMI of 25-35. The surgery creates a second food pathway to help control blood sugar, similar to popular diabetes drugs. About 90 adults will be randomly assigned to different gro…

This study aims to translate and test a questionnaire called PainPREDICT for Thai-speaking adults with type 1 or type 2 diabetes to screen for painful diabetic neuropathy, a common complication causing nerve pain. Researchers will also develop a mobile app version and check how a…

This study is testing whether using a smartwatch along with personalized digital health coaching can help people at risk for or with early-stage chronic conditions (like high blood pressure, prediabetes, or obesity) become more active and improve their health. About 1,700 adults …

This study tests whether a diet tailored to a person's unique metabolism can prevent type 2 diabetes better than standard dietary advice. Researchers will group 240 overweight or prediabetic adults by their metabolic type and give each group a personalized diet plan. The goal is …

This study is testing whether using a continuous glucose monitor (CGM) helps people with diabetes feel more in control of their blood sugar after they leave the hospital. About 60 adults with type 1 or type 2 diabetes will use a CGM for a short time and answer questionnaires abou…

This study looks at two dental procedures—complete pulpotomy and root canal treatment—in people with type 2 diabetes who have a painful tooth nerve condition. The goal is to see which treatment works better and how it affects quality of life. About 106 adults aged 18 to 70 with w…

This study tests whether a 4-week online self-compassion training program is helpful and acceptable for adults with type 1 or type 2 diabetes who are struggling with diabetes-related distress. About 50 participants will be randomly assigned to the program or a control group. The …

This study looks at whether regularly screening for diabetes-related emotional distress can help adults with type 2 diabetes improve their blood sugar and cholesterol. About 1,250 adults with type 2 diabetes and high blood sugar will take part. The goal is to see if addressing em…

This study will follow 296 Vietnamese adults with type 2 diabetes for one year to compare how quickly beta cells (which make insulin) decline in people diagnosed before age 40 versus those diagnosed at 40 or older. Researchers will measure blood markers like C-peptide and HbA1C a…

This study looks at how body weight influences physical activity, balance, and quality of life in people with type 2 diabetes. Researchers will measure things like walking ability, muscle strength, and body composition in 50 adults. The goal is to better understand these connecti…

This study is observing 500 adults with type 2 diabetes to understand how their mental well-being, depression, and quality of life are connected. Participants will fill out questionnaires about their feelings and daily life. The goal is to find patterns that can help doctors offe…

This study looks at how common memory problems are in people aged 65 and older with type 2 diabetes. It also tests whether a program that combines healthy habits, exercise, and mental activities can help prevent or slow down memory decline. The study involves 420 participants fro…

This study looks at whether a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than the standard finger-stick method. About 70 participants will be randomly assigned to use either a CGM or finger-stick testing from enrollme…

This study tests a program to help doctors screen for chronic kidney disease (CKD) in people with type 2 diabetes. Researchers will see if the program increases the number of patients who get the recommended kidney lab tests. The study involves 750 adults who are missing these te…

This study watches how doctors treat type 2 diabetes patients who are malnourished or at risk. About 334 adults will be followed for 6 months after being prescribed a special high-calorie, high-protein drink with fiber. Researchers will check health records and surveys to see how…

This study gives continuous glucose monitors (CGMs) to 40 Hispanic/Latinx young adults aged 18-45 with recent type 2 diabetes. Over 30 days, researchers will interview participants and track data to learn what helps or hinders CGM use, how awareness of glucose patterns changes, a…

This observational study looks at how the pancreas works in 310 adults with type 2 diabetes. Researchers want to see if some patients actually have a different form of diabetes called pancreatogenic diabetes. Participants will give blood and stool samples, have a pancreas ultraso…

This study looks at how people with type 2 diabetes imagine movements, sense their bodies, and think. Researchers will test 100 adults aged 18-65 who have had diabetes for at least 5 years. Participants complete questionnaires and timed tasks—no treatment or medication is involve…

This study looks at how people with type 2 diabetes break down polyphenols—natural compounds found in plants—compared to healthy individuals of the same age. Researchers will measure these compounds in urine after participants take a polyphenol-rich pill. The goal is to understan…

This study looks at how to better detect and manage diabetic retinopathy, an eye problem caused by type 2 diabetes. Researchers will use eye images, clinical data, and blood tests to create an early warning system and tailor treatment based on when diabetes started and other heal…