TUBERCULOSIS

This study tests if a 2-month combination of TB drugs works as well as the usual 4-6 month treatment for children under 10 with drug-susceptible TB. The shorter regimen aims to be easier for kids to complete and reduce side effects. About 860 children will take part to compare sa…

This study tests a new tuberculosis (TB) vaccine called MTBVAC in 276 adolescents and adults in South Africa, both with and without HIV. The goal is to see if the vaccine is safe and triggers a strong immune response. TB is a major threat for people with HIV, so finding a vaccine…

This study tests if people with tuberculosis (TB) but no symptoms can be treated with a shorter course of medication—17 weeks instead of the usual longer regimen. Researchers will compare the success rates and relapse rates between the shorter and standard treatments. The trial i…

This study tests whether adding the antibiotic doxycycline to standard tuberculosis (TB) treatment can reduce lung damage and improve heart health. About 150 adults with active TB and lung cavities will receive either doxycycline or a placebo for 8 weeks. Researchers will measure…

This study tests whether adding the cholesterol-lowering drug atorvastatin to standard TB treatment can help clear the infection faster and improve lung health. About 440 adults and children with new, untreated pulmonary TB will receive either standard care or standard care plus …

This study in Uganda tests whether trained peer educators can help people with tuberculosis (TB) and HIV stick to their treatments. About 1,920 adults will take part, with some clinics using the peer-led approach and others using standard care. The goal is to see if this method i…

This study tests a new drug (JDB0131) combined with other medicines for people with a tough type of tuberculosis that doesn't respond to the usual antibiotic rifampin. About 60 adults and teens will receive either the new drug or an existing one (delamanid) for 8 weeks. The goal …

This study tests whether a simpler two-drug HIV regimen (dolutegravir/lamivudine) works as well as the standard three-drug regimen for people starting HIV treatment while also being treated for tuberculosis. About 150 participants will be randomly assigned to one of three treatme…

This study tests a new program called QUIT-AD that combines existing methods to help people with HIV or TB quit smoking. The program will be offered to 86 adults in Cape Town, South Africa who smoke daily. Researchers will check if the program is practical, well-liked, and helps …

This study tests whether adjusting the dose of the TB drug rifampin based on a simple urine test can help more people reach effective drug levels in their blood. The goal is to improve treatment success and reduce the risk of drug resistance. The trial involves 200 adults and chi…

This study tests a 4-session counseling program to help people with tuberculosis (TB) and HIV reduce unhealthy alcohol use. The program is added to regular TB and HIV care in India. Researchers will check if it lowers drinking and improves TB and HIV health outcomes. About 450 ad…

This study is testing a new blood and urine test that looks for TB DNA to diagnose active tuberculosis and monitor how well treatment is working. The test aims to be faster and less invasive than current methods, which often require sputum samples or tissue biopsies. Researchers …

This study tests whether a smartphone app can tell the difference between a TB cough and other coughs by analyzing audio recordings. Researchers will collect cough sounds from 1,751 people with a prolonged cough and use machine learning to develop a quick triage tool. The goal is…

This study is testing a new blood test that uses CRISPR technology to find tuberculosis (TB) in children more easily and accurately. Current tests often miss TB in kids because they have fewer bacteria, especially in countries with limited resources. The study will enroll about 1…

This study tests a new skin test called EEC to see if it can better diagnose tuberculosis (TB) infection in people aged 3 and older. Researchers will compare EEC to existing tests in about 1,784 participants, including those with TB, other lung diseases, and healthy volunteers. T…

This study aims to find faster, simpler, and cheaper ways to diagnose tuberculosis (TB), a disease that kills over a million people each year. Researchers will test new diagnostic tools on over 26,000 adults in 10 countries who have a cough lasting two weeks or more, or who have …

This study aims to find faster, simpler, and cheaper ways to diagnose tuberculosis (TB) in children under 15. Every year, about 230,000 children die from TB, often because current tests are slow or hard to use. Researchers will enroll 2,100 children with TB symptoms to see how we…

This study tests new, faster, and cheaper ways to diagnose tuberculosis (TB) at the point of care. It will involve 1,350 adults with a cough or TB risk factors. The goal is to find better tests that can help identify the millions of people with TB who are currently missed.

This study tests whether giving tuberculosis (TB) preventive medicine right away to children and teens who live with a TB patient can prevent them from getting infected. About 647 participants aged 5 to 17 will either get immediate treatment or standard care. The goal is to see i…

This study tests whether a 1-month, ultra-short TB prevention regimen works as well as the standard 3-month treatment for school students and staff who have been in close contact with someone with active TB. About 3,520 participants aged 13 and older will be enrolled. If successf…

This study tests whether adding balloon-blowing exercises to standard breathing techniques helps children with tuberculosis clear mucus from their lungs, feel less breathless, and walk farther. About 34 children aged 8 to 14 will be randomly assigned to either breathing exercises…

This study aims to find more tuberculosis (TB) cases by improving diagnostic tools already available in low-resource clinics. About 1,584 adults with TB symptoms in Guinea-Bissau and Ethiopia will be tested using enhanced methods like instructed sputum collection, chest X-rays wi…

This study looks at how certain immune cells (monocytes and macrophages) behave in people with sarcoidosis, an inflammatory disease, compared to those with tuberculosis. Researchers will analyze blood and tissue samples from 100 participants to find patterns that may explain why …

This study is testing simple decision-making guides to help doctors at district hospitals and health centers in Mozambique and Zambia better diagnose and treat tuberculosis (TB) in children. Over 30,000 sick children under 15 will take part, including those with HIV or severe mal…

This study looks for better ways to find and prevent tuberculosis (TB) in people living with HIV, especially children and teens. Researchers will test a new screening method and a support program to help patients complete TB prevention treatment. The goal is to reduce TB deaths, …

This study aims to find out if people with tuberculosis (TB) who have no symptoms can pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track how TB spreads. The goal is to better understa…

This study looks at why some people with tuberculosis (TB) feel worse after starting treatment, a condition called a paradoxical reaction. Researchers will follow 140 adults on TB therapy, with or without these reactions, using blood tests, urine samples, and PET/CT scans over 6 …

This study aims to learn more about tuberculosis (TB) by collecting blood and other samples from people with active or latent TB. Researchers want to better understand how the disease works and how it affects the body. Participants will provide samples and may receive treatment f…

This study enrolls 750 people who have finished standard TB treatment to see if new blood or sputum tests can predict whether their TB will come back within a year. Current methods for predicting TB recurrence are not very accurate, making it hard to test new treatments. By findi…

This study looks at how the immune systems of people being treated for tuberculosis respond to COVID-19 vaccines compared to healthy people. About 108 adults (54 with TB and 54 healthy) will receive one or two doses of a standard COVID-19 vaccine. Researchers will measure antibod…