TUBERCULOSIS

This study aims to improve survival for adults with HIV who develop life-threatening sepsis in sub-Saharan Africa. Researchers are testing whether adding a steroid (hydrocortisone) and a stronger combination of antibiotics to the current standard treatment helps more people survi…

This study is testing a shorter, all-pill treatment for a difficult form of tuberculosis (TB) that resists standard antibiotics. It will enroll 120 Chinese participants aged 12 and older to see if a 9-month course of four specific oral drugs is effective and safe. The goal is to …

This study compares two biopsy methods to improve tuberculosis diagnosis in swollen chest lymph nodes. Researchers will test whether a newer 'frozen biopsy' technique provides better tissue samples than the standard needle method. The trial will enroll 108 adults with suspected T…

This study aims to see if using new, easier diagnostic tests for tuberculosis (TB) can help healthcare clinics find and report more TB cases. Researchers will compare clinics using a package of new tests and community outreach against clinics using standard methods. The goal is t…

This study is testing a new, non-invasive blood and urine test to diagnose tuberculosis (TB) and monitor treatment. It aims to provide a faster, easier alternative to current methods like sputum samples or invasive biopsies, which can be difficult for some patients. Researchers w…

This study is testing whether having community health workers visit homes is better than standard clinic care at getting children who live with a TB patient to start and finish a course of preventive medicine. It will involve about 1,300 children under 15 in southern Ethiopia. Th…

This study aims to find the safest and most effective dose of a 28-day medicine combination to prevent tuberculosis (TB) in children under 13 years old. It will include up to 144 children, both with and without HIV, who are at risk of getting TB. Researchers will closely monitor …

This study aims to create a simple scoring system to help doctors quickly identify which hospitalized patients likely have tuberculosis and need isolation. Researchers will collect health information from about 686 adults suspected of having TB at an Italian hospital. The goal is…

This study aims to see if a new, faster lab test can help doctors monitor how well tuberculosis (TB) treatment is working. Researchers will follow 300 adults in Kenya who are starting TB treatment, collecting samples regularly for six months. They will use the new test to measure…

This research study aims to understand how the body's immune cells behave differently in people with various lung diseases like asthma, COPD, and pneumonia. Researchers will analyze a single blood sample from 100 participants to look for patterns in how certain white blood cells …