TUBERCULOSIS

This study tests whether extra nursing care, both in the hospital and at home, can help people with tuberculosis stick with their treatment. Many patients stop treatment early, which can lead to relapse and spread of the disease. The study will enroll 40 adults and track how many…

This study tests a 9-month, all-oral drug combination (BLMZ) for people with rifampicin-resistant tuberculosis. About 120 participants aged 12 and older will take the pills and be monitored for 24 months. The goal is to see if this shorter treatment works well and is safe for Chi…

This study tests whether tuberculosis (TB) treatment can be personalized based on a person's risk of poor outcomes. About 900 adults with drug-sensitive TB will be grouped as lower-risk or higher-risk. Lower-risk participants may get a shorter treatment, while higher-risk partici…

This study tests whether adding a steroid (hydrocortisone) and a powerful antibiotic combination to standard care can help more people with HIV survive sepsis, a life-threatening infection reaction. About 344 adults in Africa will take part. The goal is to find a better treatment…

This study tests a newer biopsy method (EBUS-TBMC) against a standard one (EBUS-TBNA) for diagnosing tuberculosis in the lymph nodes of the chest. About 108 adults with suspected TB will have both procedures during the same visit. The goal is to see which method finds TB more acc…

This study tests whether new, easier-to-use diagnostic tests can help find more tuberculosis (TB) cases in Indonesia. About 40,000 people with TB symptoms will take part. The goal is to see if these tests lead to more people being diagnosed and treated sooner.

This study tests whether having health workers visit families at home can help more children under 15 start and finish tuberculosis (TB) prevention treatment compared to the usual clinic visits. About 1,300 children in southern Ethiopia will take part. The goal is to find a bette…

This study is testing a 28-day daily treatment (rifapentine plus isoniazid) to prevent tuberculosis (TB) in children under 13 years old, including those with HIV. About 144 children will take part, split into two groups based on HIV status. The goal is to find the best dose and e…

This study will test a new rapid test called PATHFAST TB LAM to see if it can help monitor treatment for tuberculosis (TB). Researchers will follow 300 adults in Nairobi, Kenya, during their 6-month TB treatment, collecting sputum and urine samples at regular visits. The goal is …

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will analyze a single blood sample from 100 adults to see how certain immune cells respond to inflammation and infection. Participants won't re…

This study aims to collect information from 686 people with confirmed or suspected tuberculosis at a hospital in Italy. Researchers will use this data to create a simple risk score that helps doctors quickly decide who needs to be isolated and who does not. The goal is to improve…