TUBERCULOSIS

This early-stage trial tested two experimental vaccines (BNT164a1 and BNT164b1) against tuberculosis in 120 healthy adults who had never received a TB vaccine or been exposed to TB. The main goal was to check safety and find the best dose. Participants received three shots and we…

This study tested whether adding zinc and selenium to the diet, through specially made cookies, could help tuberculosis patients fight the infection. Researchers gave the cookies to 90 adults with TB and measured changes in their body measurements, blood, and immune markers. The …

This study tested a once-daily HIV medication (tenofovir-emtricitabine plus efavirenz) in 70 adults with both HIV and tuberculosis. The goal was to see if a simpler, once-daily pill routine could effectively control HIV while being safe for people also being treated for TB. The m…

This study looked at how safe and effective the drug bedaquiline is for children and teens with a hard-to-treat form of tuberculosis (TB) that is resistant to the antibiotic rifampin. Fifty-four participants, some also living with HIV, received bedaquiline along with their person…

This study tested two different doses of the drug linezolid, combined with three other medicines, to treat drug-resistant tuberculosis (TB). The goal was to see if a lower dose could work just as well but with fewer side effects. 138 adults with drug-resistant TB took part, and r…

This study tested new combinations of tuberculosis (TB) drugs in 127 adults with drug-sensitive TB. Participants received one of several two-drug combinations or standard care for 14 days, then switched to standard treatment. The goal was to see how quickly the drugs killed TB ba…

This study tested whether a stronger tuberculosis (TB) treatment could reduce deaths in people with HIV who have very low immune cell counts (CD4 ≤ 100). Over 1,300 hospitalized adults and teens received either an intensified drug regimen (with extra rifampicin, isoniazid, predni…

This study looked at whether adding metformin, a diabetes medicine, to the usual antibiotics for tuberculosis (TB) is safe and tolerable for people also living with HIV. 112 adults took part, and half received standard TB drugs alone while the other half also took metformin for 1…

This study tested whether giving early treatment for cytomegalovirus (CMV) and tuberculosis (TB) can help HIV-infected infants with severe pneumonia survive. Over 500 babies under one year old were enrolled. The goal was to see if this approach reduces deaths in the short and lon…

This study tested different ways to diagnose tuberculosis (TB) in over 14,000 people across seven countries. The goal was to find which tests work best in local clinics and for groups that often miss diagnosis, like people with HIV and refugees. Researchers hope to make TB testin…

This study aimed to create a simple score to help doctors diagnose tuberculosis (TB) in hospitalized children aged 2 to 59 months who also have severe acute malnutrition. Researchers in Uganda and Zambia tested different diagnostic methods in 603 children. The goal was to develop…

This study tested a new stool-based test to diagnose tuberculosis (TB) in children and people living with HIV in Mozambique, Eswatini, and Uganda. The goal was to see if this simple, non-invasive test could find more TB cases than current methods. Over 1,900 participants provided…

This study tested two methods for finding tuberculosis (TB) in communities in Lesotho and South Africa. About 20,000 adults took part. One method used only a chest X-ray with computer analysis (CAD4TB). The other added a quick blood test for inflammation (CRP). Both methods were …

This study tested whether giving tuberculosis (TB) preventive medicine in the community, with fewer refill visits, helps more people finish their treatment compared to standard monthly clinic visits. Researchers enrolled 301 South African adults at risk for TB, including those wi…

This study tested a new approach to find and prevent tuberculosis (TB) in people living with someone who has TB. Over 7,400 participants in Thailand were involved. The goal was to see if this strategy could get more people started on preventive treatment quickly, compared to the …

This study tested a simple change in how clinics prescribe TB prevention medicine to people with HIV. Instead of doctors having to choose to prescribe it, the new approach made TB prevention the automatic option unless the doctor decided to opt out. Over 50,000 adults in South Af…

This study looked at how a single dose of the drug pretomanid works in 32 children with rifampicin-resistant tuberculosis (TB), some of whom also had HIV. Researchers measured drug levels in the blood and checked for side effects. The goal was to gather information to help design…

This study looked at how the tuberculosis drug pretomanid is handled by the body in people with different levels of kidney function. Twelve adults with kidney impairment and healthy volunteers took a single dose to compare drug levels and safety. The goal is to find the right dos…

This study looked at why some people infected with TB bacteria get sick while others don't. Researchers focused on two factors: malnutrition and parasitic worms. They studied 120 household contacts of TB patients in India, providing food to those who were malnourished and dewormi…

This study looked at 200 adults with HIV in Liberia to compare two ways of checking for hidden tuberculosis (TB) infection: a skin test and a blood test. The goal was to see which test works better in this group. Participants had both tests and results were compared. This researc…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can help doctors screen, diagnose, and manage patients with respiratory diseases like COPD, asthma, and COVID-19. Over 600 participants used the app to track their coughs, and researchers compared the app's…

This study tested a new way to find people exposed to tuberculosis (TB) in Cali, Colombia. Instead of relying only on in-person visits, researchers used a mobile health chatbot and at-home oral sample collection. The goal was to see if this approach was practical and acceptable f…

This study used a special PET scan to track where the tuberculosis (TB) drug pretomanid goes in the body. Ten people with TB received a tiny radioactive version of the drug so researchers could see how much reaches infected areas in the lungs. The goal was to learn more about how…

This study tested whether bringing a portable TB test (Gene Xpert) directly to communities in a small van can help find and treat more people with tuberculosis (TB) than the usual method of going to a clinic. Over 3,500 adults in South Africa with TB symptoms took part. The goal …

This study looked at whether testing children hospitalized with severe pneumonia for tuberculosis (TB) right away, using a rapid test called Xpert Ultra on stool and nose samples, could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB-burden countries took pa…

This study looked for tuberculosis (TB) cases in over 5,600 people who had already completed a COVID-19 vaccine trial. Researchers checked how many had TB, what factors increased their risk, and looked for blood markers that might help diagnose TB earlier. The goal was to better …

This study looked at how HIV and tuberculosis (TB) medications are processed in the body during pregnancy and after childbirth. Researchers measured drug levels in 205 women to see if standard doses provide enough protection for both mother and baby. The goal was to gather inform…

This study looked at how to best prevent tuberculosis (TB) in Malaysian prisons, focusing on inmates with and without opioid dependence. Researchers compared two TB prevention treatments: a standard daily medicine for 40 weeks versus a shorter weekly combination for 12 weeks. The…

This study tested a new method to evaluate tuberculosis (TB) drugs and vaccines in 20 healthy adults. Researchers used a harmless version of the TB bacteria (BCG) to see how the body fights it and how treatments work. The goal was to create a faster, safer way to test new TB trea…

This study looked at how two tuberculosis drugs, rifapentine and moxifloxacin, are processed in the body. Researchers took blood samples from 53 adults with TB to measure drug levels and see how they relate to treatment success and side effects. The goal is to improve dosing for …