TUBERCULOSIS

This early-stage trial tested the safety of two new tuberculosis vaccine candidates in healthy adults who had never received the standard BCG vaccine. Researchers gave 120 participants different dose levels of the experimental vaccines or a placebo to check for side effects and i…

This study tested whether adding treatments for tuberculosis (TB) and cytomegalovirus (CMV) to standard pneumonia care improves survival in HIV-infected infants with severe pneumonia. Researchers in six African countries enrolled 563 hospitalized babies aged 1-12 months. Infants …

This study tested a new drug, GSK3036656, combined with other TB medications to see how quickly it could kill tuberculosis bacteria in the lungs over 14 days. It involved 127 adults newly diagnosed with drug-sensitive TB. After the 14-day test period, all participants switched ba…

This study aimed to understand how the body processes high doses of two tuberculosis drugs, rifapentine and moxifloxacin. Researchers measured drug levels in the blood of 53 TB patients to see how these levels relate to how well the treatment works and its safety. The goal was to…

This study aimed to find safe and effective doses of the drug bedaquiline for children and adolescents with a hard-to-treat form of tuberculosis (TB) that resists standard antibiotics. It involved 54 young participants, from infants to teens, who also received their standard TB t…

This study tested whether eating cookies fortified with zinc and selenium could help improve the immune response in people being treated for tuberculosis. Researchers gave specially baked cookies to 90 tuberculosis patients to see if the added minerals would help their bodies fig…

This study tested a new approach to find tuberculosis (TB) in young children hospitalized with severe pneumonia in six high-risk countries. Researchers wanted to see if using a fast, sensitive test on easy-to-collect samples (like nasal fluid and stool) right when a child arrives…

This study tested two different approaches to prevent tuberculosis (TB) in Malaysian prisons, where many inmates have opioid addiction, HIV, or hepatitis. Researchers compared a standard 40-week daily treatment against a shorter 12-week weekly treatment to see which worked better…

This study tested whether adding the common diabetes medication metformin to standard antibiotic treatment for tuberculosis (TB) is safe and helps people recover better, especially for those also living with HIV. Researchers wanted to see if metformin could help clear the TB infe…

This large Phase 3 trial tested whether a stronger, intensified tuberculosis (TB) treatment regimen could save more lives than standard TB treatment in HIV patients hospitalized with TB and severely weakened immune systems (CD4 ≤ 100 cells/μL). It enrolled 1,330 adults and adoles…

This study aimed to find better ways to diagnose tuberculosis (TB) in local clinics and among vulnerable groups. Researchers tested different combinations of simple TB tests on nearly 15,000 people across seven countries. The goal was to identify test packages that are accurate, …

This study tested whether a smartphone app called Hyfe Cough Tracker could help monitor and manage coughs in people with various respiratory diseases. Over 600 participants with conditions like COPD, asthma, or COVID-19 used the app to record their coughs for up to 30 days. Resea…

This study tested two ways to screen for tuberculosis (TB) in communities in South Africa and Lesotho, where many cases go undiagnosed. It compared using a chest X-ray analysis software alone against combining that software with a simple blood test, before confirming any suspecte…

This study tested a new, easier way to diagnose tuberculosis (TB) using a stool sample instead of hard-to-get sputum. It focused on young children and people living with HIV in Mozambique, Eswatini, and Uganda, where TB is common. The goal was to see if this simpler test could he…

This study aimed to create a faster, simpler way to diagnose tuberculosis (TB) in young children who are severely malnourished and hospitalized. Researchers in Uganda and Zambia tested a combination of easy-to-collect samples and scans to develop a scoring system. The goal was to…

This study tested a new way to help clinics prevent tuberculosis (TB) in people living with HIV. Researchers changed the clinic paperwork so that TB prevention medication was automatically included on a patient's prescription, and a doctor had to actively choose to remove it. The…

This study tested whether delivering tuberculosis (TB) prevention medicine directly to people's communities helps more people finish their full course of treatment compared to the standard method of requiring monthly clinic visits. It involved 301 adults in South Africa who were …

This study screened 5,694 people who had previously participated in a vaccine trial to find cases of tuberculosis, including hidden infections without symptoms. Participants received chest x-rays and sputum tests, and researchers collected blood samples to look for biological mar…

This study aimed to develop a new, faster method for testing future tuberculosis (TB) drugs and vaccines. Twenty healthy volunteers received a small, safe skin injection of the BCG vaccine (a weakened TB-related germ). Researchers then took skin samples to see how the body reacte…

This study aimed to understand how a tuberculosis drug called pretomanid is processed by the body in people with different levels of kidney function. It involved 12 participants, some with healthy kidneys and some with mild to severe kidney impairment. Each person received a sing…

This study aimed to understand how the body processes HIV and tuberculosis medications during pregnancy and after birth. Researchers observed 205 pregnant and breastfeeding women who were already taking these medications for their health care. They measured drug levels in the mot…

This study tested a new strategy to find people exposed to tuberculosis (TB) in Colombia. Researchers used a mobile app (chatbot) to communicate with patients and their household contacts and collected oral swabs for testing instead of traditional sputum samples. The main goal wa…

This study aimed to understand why some people exposed to tuberculosis bacteria get sick while others don't. Researchers in India examined how malnutrition and worm infections affect the immune system's ability to fight TB. They studied 786 household contacts of TB patients, meas…

This small study aimed to understand how a tuberculosis drug, pretomanid, moves through and concentrates in the bodies of patients. Researchers used a special PET scan to track a tiny, safe amount of a radioactive version of the drug in 10 people with TB. The goal was to see if t…