TUBERCULOSIS

This large study is testing an experimental vaccine called M72/AS01E-4 to see if it can prevent tuberculosis (TB) in adolescents and adults. About 20,000 volunteers are taking part, including people with and without prior TB infection, as well as those living with HIV. The vaccin…

This early-stage study tests a new tuberculosis (TB) vaccine called Ad5-105K in 36 healthy adults aged 18 to 49 who have a positive TB blood test but no active disease. The main goal is to check the vaccine's safety and how well the body's immune system responds. Participants wil…

This study tests two experimental vaccines (BNT164a1 and BNT164b1) to prevent tuberculosis (TB) in adults who have already received the BCG vaccine and are HIV-negative. About 497 participants will receive up to three doses to find the safest and most effective dose. The goal is …

This study tests a combination of digital tools, family support, and healthcare worker training to improve tuberculosis (TB) detection and treatment adherence in South Ethiopia. About 278 TB patients, their families, and health workers will take part. The goal is to see if these …

This study tests whether a food supplement called Nyaditum resae® can reduce the gut problems caused by standard tuberculosis (TB) antibiotics. About 48 adults with new, drug-sensitive TB will take either the supplement or a placebo alongside their regular TB treatment. The goal …

This study tests a once-weekly, 12-dose treatment for latent tuberculosis (TB) in children and teens with HIV. The goal is to see if it is safe and how it interacts with their HIV medication dolutegravir. About 92 participants aged 3 months to 17 years will be enrolled.

This study tests if a one-month daily TB prevention treatment works as well as a three-month weekly one in people with HIV and in HIV-negative household contacts of TB patients. The goal is to see which approach leads to better treatment completion and fewer side effects. About 1…

This study looks at whether giving the BCG vaccine as an inhaled mist works better than the usual injection for people who have already had BCG. It also checks if people with type 2 diabetes respond differently. Thirty-six healthy adults will take part, and researchers will measu…

This study tests a new tuberculosis (TB) vaccine called ID93/GLA-SE for safety and immune response. 48 healthy adults, some previously vaccinated with BCG and some not, will receive the new vaccine and then be exposed to a harmless aerosol form of BCG to see how their immune syst…

This study tests whether computer-assisted X-rays and other simple tests can help find undiagnosed tuberculosis (TB) and COVID-19 in African communities. About 26,200 adults will be screened using these tools to see if they speed up detection and reduce the number of missed cases…

This study looks at how tuberculosis medications travel from a mother's blood into her breastmilk and then to her nursing baby. Researchers will take blood and milk samples from 20 mothers and small blood samples from their infants at several time points after a dose. The goal is…

This study aimed to see if the BCG vaccine could protect healthy adults from tuberculosis (TB) by measuring how the body fights the bacteria. It planned to enroll 64 people aged 18-45, giving some the vaccine and later a controlled exposure. However, the study was withdrawn befor…