TRAUMA

This study is testing a bone substitute called Mg OSTEOCRETE in 10 adults who need it to fill bone gaps caused by tumor removal, trauma, or loose orthopedic hardware. The goal is to measure how long it takes for the bone to heal and to see if patients feel better. The treatment i…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. About 640 incarcerated adults from 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests whether giving calcium before reaching the hospital and vasopressin early in the hospital can help people with severe bleeding after a traumatic injury. About 1,050 participants at risk of hemorrhagic shock will be enrolled. The goal is to see if these treatments…

This study tests a special gel called Onyx™ LES to stop active bleeding in arteries outside the brain and heart. About 119 adults with severe bleeding from trauma, ulcers, or other causes will receive the gel during a procedure. The goal is to see if it safely stops bleeding with…

This trial tests a special foam called ResQFoam that expands inside the belly to stop life-threatening bleeding from injuries. About 40 people with severe internal bleeding who need emergency surgery will receive the foam. The goal is to see if it safely raises blood pressure and…

This study tests whether a program led by peers—combining acceptance and commitment therapy, exercise, and social support—can help women living with HIV take their medication more consistently. About 300 women who have HIV, use substances, and have experienced violence will take …

This study tests whether a fast-acting powder form of fibrinogen (a protein that helps blood clot) works better than the standard frozen blood product for severe trauma patients with major bleeding. About 850 adults from Australia and New Zealand who need blood transfusions and h…

This study looks at whether giving trauma patients whole blood instead of separate blood parts (red cells, plasma) before they reach the hospital is practical and improves outcomes. About 60 adults with major traumatic bleeding will be randomly assigned to receive either two unit…

This study is checking how safe and effective a device called the GORE TAG Thoracic Branch Endoprosthesis is for people with a bulging or torn aorta in the chest, or an injury there. About 200 people in Japan will get the device. The goal is to make sure it works well and has few…

This study tests a program called EMPOWER to help family members who make medical decisions for critically ill patients. It compares EMPOWER to supportive conversations to see if it reduces symptoms of grief, PTSD, and depression. About 172 participants will be followed for up to…

This study tests whether training obstetric clinicians in trauma-informed care can improve mental health and mother-infant bonding in pregnant women who experienced childhood abuse. Sixty first-time mothers in Buenos Aires will be randomly assigned to receive either standard care…

This study looks at whether giving magnesium sulfate through an IV can help manage pain and reduce the need for strong painkillers in trauma patients in the intensive care unit (ICU). About 156 adults with injuries will receive either magnesium or a saltwater solution. The goal i…

This study tests which parts of therapy work best to help children aged 8-17 with post-traumatic stress disorder (PTSD) after a traumatic event. Researchers will compare different treatment components to a placebo to see what reduces symptoms most. Participants will attend weekly…

This study tests a method called cryoneurolysis, which uses a small tool to freeze the nerves that cause pain from broken ribs. The goal is to see if this approach is practical and can reduce pain and complications. 24 adults with broken ribs will receive this treatment alongside…

This study compares a nonopioid pain control regimen to standard opioid painkillers in 75 adults after clavicle fracture surgery. The goal is to see if the nonopioid approach controls pain just as well while reducing opioid risks. Participants are randomly assigned to one of two …

This study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) for adults who had childhood trauma and are currently thinking about suicide. The therapy combines coping skills training with trauma-focused care to reduce suicidal thoughts. The study involve…

This study tests whether adding extra support sessions to a standard mental health program helps refugees and asylum seekers feel less distressed and integrate better. About 1200 participants in Switzerland will receive the program, which is delivered by trained non-professionals…

This study is testing a special implant called IlluminOss to see if it can reduce pain and help people move better after pelvic fractures caused by cancer that spread to the bone or by aging. About 100 adults will receive the implant as part of their normal care, and they will fi…

This study looks at whether doing yoga during pregnancy can lower a woman's fear of a traumatic birth and improve how she sees herself and her body. Researchers will work with 46 pregnant women who are at least 16 weeks along and have a low-risk pregnancy. The goal is to see if y…

This study gathers information from trauma patients with acute subdural hematoma (a type of brain bleed) to compare standard surgery and a newer procedure called middle meningeal artery embolization. Researchers will review medical records from about 100 adults treated at one hos…

This study aims to see if updated criteria for activating trauma teams reduce mistakes—either calling a team when not needed or missing a serious case. Researchers will compare data from 5,000 trauma patients treated at Methodist Dallas Medical Center before and after the new rul…

This study looks back at medical records of 100 trauma patients who had surgery for colon injuries. The goal is to find which surgical methods lead to the best recovery. No new treatments are given; instead, researchers analyze past data to improve future care.

This study looks back at the records of about 8,000 people who had a spleen injury from trauma. The goal is to understand when doctors choose a small procedure (embolisation) instead of open surgery or just watching, and which method works best. No new treatments are given; the r…

This study looks at how cannabidiol (CBD), a non-intoxicating cannabis compound, affects the brain and body's response to stress. Researchers will recruit 160 young adults aged 18-25 who experienced early life adversity. Participants will undergo brain scans, hormone tests, and s…

This study looks at whether a single dose of estradiol (a hormone) can lower the number of intrusive, unwanted memories after a traumatic experience. Healthy female volunteers will watch a stressful film and then record any intrusive memories over the next four days. The goal is …

This study looks at why young women with post-traumatic stress disorder (PTSD) may have a higher risk of heart disease later in life. Researchers will test if drinking beetroot juice can improve blood vessel function in 30 premenopausal women who have experienced trauma. The goal…

This study looks at trauma patients who need large blood transfusions and compares two drugs (PCC and rFVIIa) that help stop bleeding. The main goal is to see which drug causes fewer dangerous blood clots. Researchers will also track deaths, hospital stays, and other complication…

This study compares two quick scoring methods (MGAP and GAP) used in emergency rooms to predict how well multiple trauma patients will do. Researchers will track 522 adults admitted to a hospital in Iraq, recording their scores and following their outcomes like survival and lengt…

This study looks back at medical records of 5000 adults who had blunt chest or belly trauma to understand how often adrenal gland injury occurs and how it affects recovery. Researchers want to clarify conflicting reports about this rare injury. The goal is to learn more, not to t…

This study looks at how severe injuries change the brain, bone marrow, and gut, and how these changes lead to long-term anemia and recovery problems. Researchers will study 275 adults with serious blunt trauma to understand these connections. The goal is to gather knowledge that …

This study uses special high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand eye diseases. About 1,200 people with various eye conditions or healthy …

This study collects information from trauma patients who experienced cardiac arrest due to injury. Researchers will analyze the order of treatments given before arriving at the hospital, such as breathing tubes and medications. The goal is to find patterns that could lead to bett…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…