SURGERY

This study tests two surgical ways to treat peri-implantitis, an infection around dental implants. About 52 adults will get either a bone graft alone or a bone graft with a protective membrane. The goal is to see which method better controls the infection and preserves the implan…

This study tests a new surgical technique called transanal total mesorectal excision (taTME) for rectal cancer. The approach works from the bottom up to remove the tumor, which may be easier and safer than traditional methods. The study involves 100 adults with rectal cancer and …

This study follows 313 people who received the Insignia Hip Stem during total hip replacement surgery to see how well the implant works and how safe it is over 10 years. Participants have conditions like hip arthritis, avascular necrosis, or fractures. The main goals are to measu…

This study compares two weight-loss surgeries—standard duodenal switch and a newer version called SADI—in 56 adults with severe obesity (BMI over 45). Researchers track weight loss, health problems like diabetes and high blood pressure, and risks like malnutrition. The goal is to…

This study tests a bone graft material called Induce XT in 60 people having foot or ankle fusion surgery. The graft fills gaps where bone is missing to help the bones heal together. Participants will have X-rays, CT scans, and pain surveys over 12 months to see how well the bone …

This study tests whether the targeted drug lorlatinib can shrink tumors in people with stage III non-small cell lung cancer that has a specific gene change (ALK fusion). About 48 adults will take lorlatinib before possibly having surgery. The main goal is to see if the cancer com…

This study compares two surgical procedures for people with severe, long-term constipation that hasn't improved with other treatments. One surgery removes the entire colon and connects the small intestine to the rectum; the other removes only part of the colon and connects the re…

This study compares two drugs, mannitol and nitroglycerin, given during robotic surgery for prostate or bladder cancer to see if they can prevent acute kidney injury. The trial involves 90 adults with normal or mildly reduced kidney function. Researchers aim to find which drug be…

This study tests whether briefly inflating a blood-pressure cuff on the arm before surgery can reduce heart damage in high-risk patients. Over 1,200 adults undergoing non-cardiac surgery will be randomly assigned to receive the cuff procedure or a sham. The goal is to see if this…

This study looks at whether using a special air cleaning system (ActivePure) in operating rooms can reduce serious infections, complications, and death within 30 days after surgery. Over 66,000 adults having surgery lasting at least one hour are included. The goal is to see if cl…

This study looks at whether playing music before or during hernia repair surgery can help lower pain after the operation. About 308 adults having surgery at Bethesda Surgery Center will take part. Researchers will measure pain scores and how much narcotic pain medicine is needed …

This study aimed to see if having a parent on a video call during anesthesia could calm children as well as a sedative medicine (midazolam). It was designed for kids aged 4 to 8 having outpatient surgery. However, the study was withdrawn before any participants were enrolled, so …

This study tests a simple bedside exercise program for older adults (65+) recovering from surgery in the hospital. The goal is to get patients out of bed and moving earlier, which can prevent muscle loss, shorten hospital stays, and reduce complications. About 2,180 participants …

This study looks at whether listening to music can help children aged 4 to 6 feel less pain and fear when they first get up after abdominal surgery. About 74 children will take part, with half listening to their favorite music during movement and the other half getting usual pare…

This study tests whether using a bedside lung ultrasound during robotic prostate or bladder cancer surgery helps doctors set the breathing machine pressure more precisely. The goal is to prevent lung collapse and reduce breathing complications after surgery. About 88 adults with …

This study tests whether a low-cost, colorful walkway (like a mat carpet) can help children aged 4-10 feel less pain and fear when they first get up after abdominal surgery. About 74 children will use the walkway, and researchers will measure their pain, fear, and how quickly the…

This study looks at how a special clinic helps older adults get ready for major abdominal surgery. Researchers will watch and talk to doctors, staff, and patients to understand what works well and what could be better. The goal is to create a plan that other hospitals can use to …

This study follows 240 teenagers and young adults aged 13-21 to see how weight-loss surgery (gastric bypass or sleeve gastrectomy) impacts bone density and strength over two years. It compares those who have surgery with overweight teens who do not. The goal is to understand if t…

This study compares two methods of training surgeons to have clearer conversations with older patients about surgery. One method uses a human trainer, the other uses computer feedback. About 60 surgeons and 660 patients will take part to see if the automated approach works just a…

This study takes tissue that would normally be thrown away after surgery and uses it to grow cells in the lab. The goal is to create better ways to study and repair tissues in the future. Up to 1,000 people having surgery at Wake Forest may participate. There is no direct benefit…

This study aims to develop new tools that use machine learning to evaluate how well surgeons perform robotic surgery. Researchers will collect data from 1,000 surgeons performing common procedures and analyze their movements, camera use, and instrument handling. The goal is to cr…

This study tests a non-invasive sticker sensor (surface EMG) to measure how well nerve blocks work during surgery in children and young adults up to age 21. The sensor records muscle electrical activity before, during, and after surgery. The goal is to learn how to give nerve blo…

This study looks at how being in the intensive care unit (ICU) after heart surgery affects patients' sleep and internal body clocks. Researchers will track sleep depth and thinking skills in 15 adults who own an Apple smartphone. The goal is to understand how hospital routines di…

This study looks at how increasing doses of the opioid remifentanil change a person's pain threshold just before anesthesia. About 40 adults scheduled for surgery will have their pain threshold measured with a pressure device at different drug levels. The goal is to better unders…

This study tests a small sensor that measures carbon dioxide (CO2) and temperature in tissue after reconstructive surgery. If blood flow is blocked, CO2 rises and temperature drops, alerting doctors early. The goal is to see if the sensor can quickly detect tissue ischemia (lack …

This study looks at whether a structured nutrition plan can help ICU patients recover better after abdominal surgery. About 300 adults will receive a special feeding method that includes tube feeding, supplements, and a device to measure their exact calorie needs. The goal is to …

This study aimed to see if switching from isoflurane to desflurane during surgery could help adults wake up faster and leave the hospital sooner. It was planned as a quality improvement project at Cleveland Clinic for adults having general anesthesia. However, the study was withd…

This study tests whether a program of computer brain games and supervised physical exercise, done before and after major surgery, can help older adults (age 60+) maintain their thinking skills and physical abilities. 250 participants will be randomly assigned to either the traini…

This study looks at how sleep quality before surgery affects pain and painkiller use in children and teens having knee surgery. About 166 patients aged 10-18 will answer a sleep questionnaire before surgery, then researchers will track their pain and medication use for two weeks …

This study compares two methods (electromyography and acceleromyography) for monitoring muscle relaxation during robotic or laparoscopic surgery. The goal is to see which method leads to using less muscle relaxant medication. About 400 adults having planned surgery will take part…

This study aimed to see if patients could follow a short-term protein-calorie restriction diet for 4 days before elective vascular surgery. Researchers planned to measure diet compliance and changes in blood markers related to stress and healing. However, the study was withdrawn …

This pilot study tests whether allowing slightly lower blood pressure after heart surgery (permissive hypotension) is safe and can reduce the need for blood-pressure-raising drugs and shorten ICU stays. Researchers will compare this approach to usual care in 80 adults having elec…

This study aimed to see if the amount of air set on a breathing machine during children's surgery matches what actually reaches the lungs. Researchers planned to place a small sensor on the breathing tube to compare the set volume with the measured airflow. The study was withdraw…

This study examines why Black children often report more pain after tonsil removal than White children. Researchers will analyze blood samples from 84 children aged 4-17 to find chemical differences that might explain this disparity. The goal is to better understand the biology b…