SURGERY

This study tests whether adding two drugs (adebrelimab and apatinib) to standard chemotherapy (SOX) before surgery can shrink tumors more effectively in people with locally advanced stomach cancer. About 118 adults aged 18-75 with HER2-negative stomach cancer that cannot be remov…

This study looks at people with stage II to IIIB non-small cell lung cancer whose tumors shrank after immunotherapy. It compares two surgery approaches: removing only the shrunken tumor area versus removing the original larger area. The goal is to see if less surgery can preserve…

This study looks at 100 adults with liver cancer that was initially too advanced for surgery but shrank after conversion therapy. Researchers want to see if removing the remaining tumor with surgery is better than continuing maintenance therapy. The goal is to find which approach…

This study tests whether giving older patients (65-90) a combination of two medicines (dexmedetomidine and esketamine) plus a gentle brain stimulation technique (tDCS) around the time of surgery can prevent confusion, memory loss, and other thinking problems that often occur afte…

This study looks at whether giving older adults (65-90) a combination of two drugs (dexmedetomidine and esketamine) along with a gentle brain stimulation technique (tDCS) before non-cardiac surgery can prevent long-term memory and thinking problems. About 1160 participants with m…

This study tests whether adding intravenous lidocaine to standard morphine spinal anesthesia can lower the amount of morphine patients need for pain after major abdominal surgery. About 76 adults having planned open abdominal surgery will receive either lidocaine or a placebo, an…

This study compares two types of steroid injections added to standard pain control during total knee replacement. The goal is to see which option reduces pain, limits opioid use, and improves knee movement. About 240 adults with severe knee arthritis will be randomly assigned to …

This study tests whether using nerve monitoring and a gentle electric tool during armpit lymph node removal can help surgeons find and protect small nerves that often cause long-term pain after breast cancer surgery. Six adults with breast cancer will take part. The goal is to se…

This study looks at two ways of giving fluids during liver surgery. One method uses less fluid to try to reduce bleeding, while the other uses more to keep organs working well. The goal is to see which approach leads to fewer serious problems after surgery, like kidney injury. Ab…

This study looks at 200 people with Charcot-Marie-Tooth disease (CMT) who have foot problems that make walking hard. Researchers want to see if surgery to fix the foot followed by rehab leads to better walking than physical therapy alone. Participants will be followed for up to t…

This study tests whether using a wearable sensor to continuously monitor heart rate and breathing after surgery can catch problems earlier than standard spot-checks. About 522 adults having major non-cardiac surgery will be randomly assigned to either continuous monitoring with a…

This study tests whether an artificial intelligence virtual assistant (AIVA) can help plastic surgery patients by reducing the number and length of phone calls to the clinic. Researchers will track phone calls and satisfaction among 200 adult patients at Mayo Clinic Florida. The …

This study focuses on helping people with low health literacy recover better after colorectal surgery. Researchers will test a program called VISACT, which uses visual aids and coach training to improve recovery steps. About 1,050 patients and providers will take part. The goal i…

This study will use ultrasound to measure the size of two arteries in each arm of 100 children having surgery. The goal is to see if the artery sizes differ between a child's dominant and non-dominant hand. No treatment or medication is involved; it is purely observational.

This study compares how nerves communicate with muscles in infants (under 3 months) versus older patients (12 years and up) during surgery. Researchers will use a special monitor called TetraGraph to measure these signals. The goal is to understand normal differences in nerve-to-…

This study looks at how deep anesthesia affects thinking and memory recovery in older adults (65+) after non-heart surgery. Researchers will compare two different anesthesia depths using a fixed drug ratio. The goal is to see if one depth leads to fewer thinking problems after su…

This study will test a device called TetraGraph to see exactly how quickly the muscle relaxant rocuronium takes effect and wears off in 130 people having surgery. Doctors usually wait 60 seconds after giving the drug, but it doesn't always work that fast, which can make intubatio…

This study looks at how much the tensor fascia latae (TFL) muscle is damaged during hip replacement surgery through the front of the hip. Researchers want to see if more damage leads to worse recovery in the first 6 months. 150 adults getting their first hip replacement will be f…

This study will check if pulse oximeters, which measure oxygen levels, work equally well in dark-skinned (Black) and light-skinned (White) children aged 2-9 during surgery. Researchers will compare the device's readings to a more precise blood test. The goal is to see if skin col…

This study tests whether a wearable device called MultiSense® can safely monitor elderly patients (65+) at home after major surgery. The goal is to see if it reduces hospital stays and prevents emergency visits. Eighty participants will use the device after going home, and resear…