Surgery

This trial tests whether the LapBox Manual Containment System, a double-wall bag used during laparoscopic surgery, can prevent leaks when removing uterine fibroids. About 30 women having laparoscopic hysterectomy or myomectomy will use the device, and surgeons will check for any …

This trial tests a home-based program of exercise, breathing exercises, nutrition advice, and emotional support for people waiting for a kidney transplant. Participants start the program at least 4 weeks before surgery and continue for 18 weeks after leaving the hospital. The goa…

This trial tests whether a structured follow-up program after surgery can reduce the number of people still using opioids 90 days later. The program uses patient-reported recovery scores to guide care, with nurses and community providers working together. About 772 adults having …

This study tests whether adding a special type of radiation (SF-SBRT) to the usual combination of immunotherapy (toripalimab) and chemotherapy helps people with stage II-III non-small cell lung cancer live longer without the cancer coming back. About 200 participants will be rand…

This study looks at 100 liver cancer patients whose tumors shrank or disappeared after initial therapy. It compares two follow-up options: surgery to remove any remaining cancer, or continuing medication (maintenance therapy). The goal is to see which approach better prevents the…

This Phase 3 trial tests whether adding an immunotherapy drug (adebrelimab) and a targeted therapy (apatinib) to standard chemotherapy (SOX) can improve outcomes for people with locally advanced stomach cancer that cannot be removed right away. The study will enroll 118 participa…

This long-term study follows older adults (65-90) who are having non-cardiac surgery to see if a combination of two drugs (dexmedetomidine and esketamine) plus a gentle brain stimulation technique (tDCS) can prevent memory and thinking problems that sometimes occur after surgery.…

This study tests two approaches—a combination of medicines (dexmedetomidine and esketamine) and a gentle brain stimulation technique (tDCS)—to prevent confusion and memory problems after surgery in older adults. About 1,160 patients aged 65-90 with mild cognitive issues will be e…

This trial tests whether a structured exercise program can help teenagers recover balance and posture after surgery for scoliosis, a condition that curves the spine. Participants who had spinal fusion surgery will either join an 8-week supervised exercise program or receive usual…

This study tests whether giving lidocaine through an IV, along with a spinal morphine injection, can lower the amount of morphine patients need after major digestive or abdominal surgery. About 76 adults having planned open abdominal surgery will be randomly assigned to receive e…

This study explores whether a personalized music therapy session, called music-assisted relaxation and imagery (MARI), can reduce pain and change gene activity in people recovering from open surgery for stomach, pancreas, bile duct, liver, or peritoneal cancer. Participants will …

This study tests whether Shouhui Tongbian Capsules, a traditional Chinese herbal medicine, can relieve constipation after surgery for benign anal or rectal conditions like hemorrhoids. 120 adults will be randomly assigned to take either the herbal capsules or a standard laxative …

This study tests whether a patient safety checklist (PASC) helps adults recovering from major surgery feel more satisfied with their discharge education and reduces communication problems with healthcare staff. About 264 participants will either use the checklist from the day sur…

This study will give 200 plastic surgery patients access to an artificial intelligence virtual assistant called AIVA. The assistant answers questions about their upcoming surgery. Researchers want to see if this reduces phone calls to clinic staff and improves patient and provide…

This study compares nerve-muscle communication in infants (under 3 months) and older patients (12+ years) during surgery. Using a special monitor called TetraGraph™, researchers will measure muscle responses to electrical signals. The goal is to understand how these signals diffe…

This observational study will use ultrasound to measure the size of two arteries in the arms of 100 children undergoing surgery. The goal is to see if the dominant hand has larger arteries than the non-dominant hand. The findings could help guide medical procedures like placing I…

This pilot study tests whether surgeons will use a new set of timeline-specific guidelines designed to improve functional recovery after high-risk abdominal cancer surgery. Researchers will monitor how often surgeons follow the guideline in clinic. The goal is to see if such a to…

This study will track outcomes for 100,000 patients undergoing surgery in 1,000 hospitals across 100 countries. The goal is to understand how post-operative complications vary worldwide and what factors—like hospital resources—might influence them. By comparing results across inc…

This study tests a communication tool called the FOCUS Guide. It is designed to help older adults (age 65 and up) and their surgeons talk about the goal of surgery during clinic visits. The study will see if using the guide leads to more discussions and documentation of surgery g…

This study looks at how deep anesthesia affects memory and thinking in older adults (65+) after non-heart surgery. Researchers will give a fixed mix of two anesthetic drugs to 200 participants and check their brain function with a simple test. The goal is to find the best anesthe…

This study looks at two ways of giving fluids during liver surgery: one that limits fluids and one that gives more. The goal is to see which approach leads to fewer serious problems after surgery, especially kidney injury. About 90 adults having planned liver surgery will take pa…

This study looks at two ways to help people with Charcot-Marie-Tooth disease (CMT) walk better. One group gets foot surgery followed by rehabilitation, the other gets only physical therapy. Researchers will track walking speed and endurance for up to two years to see which approa…

This study examines how much the tensor fascia latae muscle is damaged during hip replacement surgery through the front approach. Researchers will compare the amount of muscle damage to how well patients recover at 6 weeks and 6 months. The goal is to understand if less muscle da…