SURGERY

This study aims to find out which treatment approach works better for improving walking ability in people with Charcot-Marie-Tooth disease (CMT), a nerve condition that causes foot deformities and walking difficulties. Researchers will compare 200 participants who either had foot…

This study aims to find the best approach to giving fluids during liver removal surgery. It will compare a restrictive fluid plan, which surgeons often prefer to reduce bleeding, with a more liberal fluid plan, which might better protect the kidneys and other organs. The goal is …

This study compares two types of lung cancer surgery for patients who have already responded well to immunotherapy. It aims to see if a less extensive surgery, which removes less lung tissue, is as effective at controlling cancer as the standard, more extensive surgery. The goal …

This study is testing whether temporarily blocking the main blood vessels to the uterus during minimally invasive fibroid removal surgery can reduce blood loss. It focuses on patients who have many fibroids or very large fibroids, as these cases typically involve more bleeding. R…

This study aims to determine whether patients with liver cancer who respond well to initial drug therapy should undergo surgery to remove remaining tumors or continue with ongoing drug treatment. Researchers will follow 100 patients across multiple hospitals to see which approach…

This study is testing whether adding one or two newer drugs to standard chemotherapy before surgery helps shrink stomach tumors more effectively. It will involve 118 adults with locally advanced stomach cancer who haven't had prior treatment for their advanced disease. Researcher…

This study aims to find out if pulse oximeters—the clip-on devices that measure oxygen levels—work as accurately for Black children as they do for White children during surgery. Researchers will compare the pulse oximeter readings to more precise blood oxygen tests in 540 childre…

This study compares two ways of monitoring patients after major surgery. One group gets standard vital sign checks every few hours. The other wears a wireless sensor that continuously tracks heart rate and breathing, alerting nurses to potential problems. Researchers want to see …

This study aims to see if two common anesthesia drugs, dexmedetomidine and esketamine, can help people feel better after surgery. Researchers will test each drug alone and together in 316 adults having surgery under general anesthesia. The main goal is to see if these drugs impro…

This study aims to find the best pain-control injection for adults having total knee replacement surgery. Researchers will compare a standard pain injection to the same injection with two different steroids added. The goal is to see which option best reduces pain, limits opioid m…

This study is testing if adding an intravenous numbing medicine (lidocaine) to standard spinal morphine pain relief can help patients use less morphine after major abdominal surgery. It will involve 76 adults having planned open abdominal surgery. Patients will be randomly assign…

This study aims to see if an AI virtual assistant on a phone app can reduce the burden of phone calls for plastic surgery patients and improve their experience. Researchers will compare 200 patients who use the AI assistant at home to those who call a standard care center with th…

This study aims to see if a specific way of giving anesthesia drugs can help protect older patients' memory and thinking skills after surgery. Researchers will compare two different levels of anesthesia depth, both delivered by a precise IV pump that mixes two key drugs in a fixe…

This study aims to understand how infants' nerves and muscles respond during surgery compared to older patients. Researchers will use a special monitoring device on 100 participants—some infants under 3 months and some patients 12 years and older—who are having surgery that does …

This study aims to improve surgery recovery for patients who struggle with understanding health information. Researchers will adapt a standard recovery program using a new support strategy called VISACT, which uses visual aids and trains healthcare teams. They will test this appr…

This study aims to use a special monitor to more accurately measure how quickly a common muscle relaxant (rocuronium) takes effect and wears off during surgery. It will involve 130 patients who need this medication for their operation. The goal is to gather better data to help do…

This study aims to understand if damage to a specific thigh muscle during hip replacement surgery affects how well patients recover in the short term. Researchers will observe 150 adults getting hip replacements through a specific surgical approach, grading any muscle damage seen…