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Which works better for CMT foot problems: surgery or therapy alone?

NCT ID NCT07432035

Knowledge-focused Sponsor: Peking University Third Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at two ways to help people with Charcot-Marie-Tooth disease (CMT) walk better. One group gets foot surgery followed by rehabilitation, the other gets only physical therapy. Researchers will track walking speed and endurance for up to two years to see which approach leads to bigger improvements. The goal is to help patients and doctors choose the best treatment for foot deformities caused by CMT.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population comprises adults with Charcot-Marie-Tooth disease (CMT) evaluated and treated at a tertiary referral center specializing in neuromuscular and foot and ankle disorders. Participants were identified from consecutive clinical encounters beginning in February 2017, incorporating both retrospectively and prospectively collected data. Eligible individuals had a genetically or clinically confirmed diagnosis of CMT and presented with foot deformity and gait impairment attributable to peripheral neuropathy. All participants were ambulatory, with or without assistive devices, at the time of enrollment. Management strategies included functional surgical intervention followed by rehabilitation or structured physical therapy alone, reflecting routine clinical practice. Longitudinal outcome data were obtained through standardized assessments conducted at baseline and predefined follow-up time points throughout the study period.

Ages

12 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants aged 12 years or older at the time of enrollment * Genetically or clinically confirmed CMT, based on established diagnostic criteria * Presence of foot deformity and/or gait impairment attributable to CMT, as determined by a treating clinician * Ability to ambulate at least 10 meters, with or without assistive devices * Medically eligible for either functional surgical intervention or structured physical therapy, as determined by the treating team * Willingness and ability to participate in longitudinal follow-up assessments * Provision of written informed consent Exclusion Criteria: * Previous major foot or ankle surgery that substantially altered lower-limb biomechanics * Presence of non-CMT-related neurological disorders affecting gait (eg, stroke, Parkinson disease, multiple sclerosis) * Severe musculoskeletal conditions unrelated to CMT that limit walking ability (eg, advanced hip or knee osteoarthritis) * Active lower-limb infection, ulceration, or acute injury at the time of enrollment * Severe cognitive impairment or psychiatric condition precluding reliable participation * Medical contraindications to surgery or exercise-based rehabilitation, when relevant * Inability to complete baseline functional assessments or anticipated inability to complete follow-up

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Conditions

The condition(s) this trial relates to.

Charcot-Marie-Tooth disease Mobility Limitation neuromuscular disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Charcot Marie Tooth disease (CMT) Exercise training Gait disorders Neuromuscular diseases (NMD) Pes cavovarus Surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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More trials for these conditions

Other studies related to the condition(s) this trial covers.