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Can anesthesia dosing protect Seniors' brains after surgery?

NCT ID NCT07479719

Knowledge-focused Sponsor: Peking University First Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how deep anesthesia affects memory and thinking in older adults (65+) after non-heart surgery. Researchers will give a fixed mix of two anesthetic drugs to 200 participants and check their brain function with a simple test. The goal is to find the best anesthesia depth to reduce confusion or memory problems after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged ≥ 65 years. 2. Scheduled to undergo noncardiac surgery expected to last ≥ 1 hour under general anesthesia. 3. Require patient-controlled intravenous analgesia after surgery. 4. Provide written informed consent. Exclusion Criteria: 1. Inability to communicate in the preoperative period because of coma, profound dementia, language barrier, or other reasons. 2. Previous history of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis. 3. Traumatic brain injury or neurosurgery. 4. Severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (eGFR \<30 ml/min/1.73 m2), or critical illness (preoperative American Society of Anesthesiologists physical status classification ≥IV). 5. Planned ICU admission with endotracheal intubation after surgery. 6. Enrolled in the other studies. 7. Other reasons that are considered unsuitable for study participation by the responsible surgeons or investigators.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Delayed neurocognitive recovery Depth of anesthesia Elderly Surgery Total intravenous anesthesia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Peking University First Hospital

    Beijing, Beijing Municipality, 100034, China

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