RECTAL CANCER

This study looks at whether a combination of radiation and chemotherapy can cure low rectal cancer, allowing patients to avoid surgery. About 108 people with early-stage rectal tumors are being followed for two years to see if the cancer stays away. Early results suggest many pat…

This study tests whether adding a stronger chemotherapy regimen (FOLFOXIRI) to standard chemoradiotherapy helps eliminate more cancer before surgery in people with high-risk locally advanced rectal cancer. About 72 participants will receive either standard treatment or the intens…

This study tests a new surgical technique called transanal total mesorectal excision (taTME) for rectal cancer. The approach works from the bottom up to remove the tumor, which may be easier and safer than traditional methods. The study involves 100 adults with rectal cancer and …

This study tests a modified stapling technique (MST) against the standard method in 450 adults having minimally invasive rectal cancer surgery. The goal is to see if MST reduces the risk of anastomotic leakage, a serious complication where the bowel connection leaks. Participants…

This study is testing a new, already-approved device that delivers radiation directly to rectal tumors in elderly patients who cannot undergo surgery. The goal is to see if the new device works as well as existing methods while being more comfortable and faster. About 45 particip…

This study tests whether adding two immunotherapy drugs (atezolizumab and tiragolumab) after standard chemoradiation can help eliminate tumors in people with locally advanced rectal cancer. About 58 participants will receive either the drug combination or atezolizumab alone befor…

This study tests a two-drug combination (cabozantinib and nivolumab) in people with advanced colorectal cancer that is microsatellite stable (MSS) and has stopped responding to standard treatments. The goal is to see if the combination can control the cancer for at least 16 weeks…

This study tests whether giving extra, precisely targeted radiation to the main tumor and affected lymph nodes before surgery can improve outcomes for people with locally advanced rectal cancer. About 128 adults with rectal cancer that has spread to nearby lymph nodes will receiv…

This study tests a new treatment plan for people with locally advanced rectal cancer. Instead of the usual long course of radiation with chemo, patients get a short course of radiation followed by 4 cycles of FOLFOX chemotherapy before surgery. The goal is to improve the chance o…

This study tests whether a combination of chemotherapy and an immunotherapy drug (sintilimab) can effectively treat locally advanced rectal cancer without using radiation. The goal is to shrink or eliminate the tumor before surgery, potentially allowing patients to avoid radiatio…

This study tests an experimental pill (GSK4418959) in adults with advanced solid tumors that have specific genetic changes (dMMR or MSI-H). The drug targets a DNA repair protein to try to shrink tumors. The trial will check safety, side effects, and how well the drug works alone …

This study was designed to test a combination of two drugs, regorafenib and lorigerlimab, in people with a certain type of rectal cancer that came back after initial treatment. The goal was to see if the combination was safe and effective. However, the study was withdrawn before …

This study tested a powerful chemotherapy combination (FOLFOXIRI) followed by chemoradiation before surgery in 40 people with high-risk rectal cancer. The goal was to shrink tumors enough to allow complete removal. Researchers measured how well the tumors responded and tracked si…

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy and radiation can improve outcomes for people with locally advanced rectal cancer. About 29 participants who have not had prior treatment will receive the combination before surgery. The mai…

This study compares two treatment plans for people with high-risk rectal cancer. The standard plan is long-course chemoradiation followed by surgery and optional chemo. The experimental plan starts with short-course radiation (5 days), then several months of chemo, followed by su…

This phase 3 trial tests whether a short course of radiation followed by immunotherapy (camrelizumab) and chemotherapy can completely eliminate rectal cancer before surgery. About 230 adults with locally advanced rectal cancer will be randomly assigned to this new approach or sta…

This pilot study tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with breast, colon, lung, or other CEA-positi…

This study tests whether using a FitBit and mobile health apps can help people who have had surgery for cancers of the stomach, liver, pancreas, colon, or small intestine avoid being readmitted to the hospital. About 107 adults who own a smartphone and are scheduled for surgery w…

This study tests a program that lets cancer patients receive care at home while undergoing chemotherapy or radiation. The goal is to see if remote monitoring and home support can reduce emergency room visits and hospital stays. About 300 adults with certain cancers (like pancreat…

This study looks at whether adding a single biofeedback session to Kegel exercises can improve bowel function, reduce emotional distress, and boost quality of life in people who had rectal cancer surgery. About 66 adults who have bowel control issues after surgery will be split i…

This study looks at four different tools to help people who have had cancer improve their diet and physical activity. About 353 cancer survivors will try these tools to see which ones work best. The goal is to find simple ways to help survivors follow healthy lifestyle guidelines…

This study looks at how different treatments for recurrent rectal cancer affect patients' well-being and quality of life. About 116 people with rectal cancer that has come back in the pelvis are taking part. Researchers use surveys to track changes in quality of life over time, a…

This study looks for brand-new gene changes that appear in a child but not in their parents, which might raise the risk of certain cancers. Researchers will compare DNA from cancer patients and their healthy parents to spot these changes. The goal is to better understand cancer r…

This study explores whether a special type of radiation therapy can protect the ovaries of young women (ages 18-50) undergoing pelvic radiation for cancers like uterine, rectal, or cervical cancer. The goal is to see if doctors can consistently see the ovaries on daily scans and …

This study compares two ways of monitoring colorectal cancer patients after surgery: standard CT scans versus a new approach that also uses a blood test (ctDNA) to find cancer DNA. The goal is to see if the blood test helps detect cancer recurrence earlier and allows more patient…

This study looks at how exercise might affect the body's processes that could stop colorectal cancer from returning. Researchers are measuring changes in blood markers linked to inflammation and cancer cells in 60 people who have finished their cancer treatment. The goal is to un…