RECTAL CANCER

This early-phase trial tested a new type of gene therapy for advanced gastrointestinal and other cancers. Researchers collected a patient's own white blood cells, genetically modified them in a lab to recognize and attack cancer cells with a specific mutation called KRAS G12D, an…

This study tested whether adding immunotherapy to standard chemotherapy and radiation before surgery could improve outcomes for people with a specific type of ultra-low rectal cancer. The goal was to shrink tumors enough so surgeons could avoid removing the anus, allowing patient…

This study compared two surgical techniques for repairing the pelvic floor after a major operation to remove advanced rectal cancer. It tested whether using a biological mesh implant led to better physical recovery six months after surgery than using a muscle flap taken from the …

This study tested whether adding the common diabetes drug metformin to standard pre-surgery chemoradiation could improve treatment for locally advanced rectal cancer. It involved 60 patients who received metformin alongside their standard radiation and chemotherapy before surgery…

This study tested a new web and text message program designed to help people who have had colorectal cancer eat healthier. Researchers wanted to see if the program was easy to use and acceptable to 50 cancer survivors over 12 weeks. The goal is to help survivors make dietary choi…

This study tested a shorter, condensed treatment approach for people with operable rectal cancer. Patients received a brief course of radiation followed by chemotherapy before their planned surgery. The goal was to see if this approach could effectively shrink tumors and allow fo…

This study tested a monitoring method called microdialysis to see if it could detect healing problems earlier after surgery for rectal cancer. Researchers placed a tiny catheter near the surgical site in 21 patients to measure local chemical changes. The goal was to identify dang…

This study tested if a quick tissue analysis during surgery helps surgeons get cleaner margins when removing rectal cancer. 99 patients who had radiation before surgery were split into two groups: one had their tumor's outer edge checked instantly during the operation, while the …

This study aimed to create and test a new tool to help doctors better understand and manage the bowel problems many people face after rectal cancer treatment. Researchers worked with 118 patients to develop a smartphone diary app that tracks symptoms in detail. The goal is to imp…

This study tested whether a new type of PET scan (using a tracer called 18F-FAPI) can accurately predict which patients with rectal cancer will have a complete response to their pre-surgery treatment. The goal is to better identify patients who might be able to avoid major surger…

This study tested whether a simple blood test using artificial intelligence could detect colorectal cancer early. Researchers collected blood samples from nearly 49,000 average-risk adults aged 45-85 who were already scheduled for routine colonoscopy screening. The goal was to se…

This study tested whether a coordinated, personalized rehabilitation program could improve life quality for people recovering from colorectal cancer. 150 patients in Slovenia were assigned to either receive standard care or a new program that connected them with specialists like …

This study compared two methods for managing pain after planned colon or rectal surgery. Researchers tested a newer nerve-block injection (TAP block) against the traditional epidural to see which better controlled pain and improved recovery. The trial involved 200 adults undergoi…

This study compared two standard methods for controlling pain after colon or rectal surgery. Researchers tested whether a simpler method using a local pain medication catheter placed near the surgical site works as well as the more complex epidural method. They measured patients'…

This study tested a new bladder training method for patients recovering from rectal cancer surgery. It compared a specific training technique involving clamping and releasing the urinary catheter while encouraging patients to urinate, against the standard approach of just drainin…

This study tested whether Spanish-language educational videos about colorectal cancer, delivered in a church setting, could increase knowledge and willingness to participate in cancer clinical trials among Latino adults. Researchers recruited 60 Spanish-speaking Latino churchgoer…

This study aimed to understand the recovery journey for people with newly diagnosed rectal cancer. Researchers followed 107 patients to track how symptoms like bowel problems, balance issues, and emotional distress changed over time. The goal was to gather information to help imp…

This study aimed to develop better tools to predict which rectal cancer patients might develop bowel problems after surgery. Researchers tested six different machine learning methods against traditional statistical approaches using data from 3500 patients. They created and valida…

This study followed 65 rectal cancer patients for one year after they had surgery to reconnect their bowel. The goal was to understand how bowel function problems after surgery affect patients' daily lives and quality of life. By tracking symptoms and complications, researchers a…

This study aimed to see if the types of bacteria in a patient's gut and mouth could help predict how well their rectal cancer would respond to chemotherapy and radiation before surgery. Researchers collected stool and saliva samples from 60 patients with locally advanced rectal c…

This study tested whether a special type of MRI scan could tell if a patient's rectal cancer was successfully treated. Researchers scanned 44 adults with rectal cancer before and after they received standard chemotherapy and radiation. The goal was to see if the scan could accura…

This study aimed to understand how common muscle loss (sarcopenia) is in people about to have colorectal cancer surgery and how it affects their recovery. Researchers followed 70 patients, measuring their muscle strength, mass, and physical ability before surgery. They then track…

This study aimed to understand how blood flow to the colon changes after a common rectal cancer surgery. Researchers used special CT scans before and after surgery on 89 patients to map the blood vessels. The goal was to see if their pre-surgery predictions about blood flow match…