RECTAL CANCER

This study looked at whether adding the diabetes drug metformin to standard chemo-radiation helps shrink rectal tumors before surgery. 60 adults with locally advanced rectal cancer took part. The main goal was to see if more patients had no cancer cells left in the removed tumor.…

This study tested an experimental drug called CTX-009 in 49 adults with metastatic colorectal cancer that had worsened after two or three prior treatments. The goal was to see if the drug could shrink tumors or stop them from growing. While not a cure, it aims to give patients mo…

This study looked at 91 adults with rectal cancer who needed pelvic floor reconstruction after surgery. It compared using a biological mesh made from pig collagen versus a muscle flap from the buttock to repair the area. The goal was to see which method led to better physical fun…

This study tested whether a short course of radiation followed by chemotherapy could eliminate the need for surgery in people with locally advanced rectal cancer. 39 participants received this treatment, and doctors monitored them to see if the cancer disappeared completely and s…

This study tested a shorter radiation course combined with TASOX chemotherapy in 13 people with stage II/III rectal cancer. The goal was to shrink tumors before surgery. Results showed the treatment was safe and helped reduce tumor stage, allowing for complete removal. This appro…

This study tested a newer, less invasive surgery for low rectal cancer that removes the tumor through the anus instead of through the abdomen. 226 adults with non-spread rectal cancer took part. The goal was to see if the new method works as well as standard laparoscopic surgery …

This study tested whether adding immunotherapy to standard chemoradiation helps people with a certain type of ultra-low rectal cancer (MSS type) avoid permanent colostomy. About 200 patients who wanted to keep their anus were enrolled. The main goal was to see how many achieved a…

This study tested whether chemotherapy followed by a less invasive surgery could help people with early rectal cancer keep their rectum instead of removing it. Fifty-eight patients took part. The goal was to see if at least 65% could avoid major surgery and still control the canc…

This study tested whether giving a stronger chemotherapy combination (Folfirinox) before standard radiation and chemo could help more people with early-stage rectal cancer avoid surgery and keep their rectum. About 218 adults with small, low-lying rectal tumors took part. The goa…

This study tested a new tool called the LUMENEYE rectoscope to see if it can better assess how well rectal cancer responds to chemotherapy and radiation. 82 patients who were good candidates for organ preservation were included. The goal was to see if the scope could accurately i…

This study tested a new blood test designed to find colorectal cancer early in people at average risk. Nearly 49,000 adults aged 45 to 85 gave a blood sample before their routine colonoscopy. The goal was to see how well the blood test could detect cancer and advanced growths com…

This study tested two standard pain control methods after colon or rectal surgery: a local anesthetic delivered through small tubes placed near the surgical site (preperitoneal analgesia) versus an epidural. About 98 adults having planned surgery took part. The goal was to see if…

This study looked at 200 adults having elective colorectal surgery for conditions like colon cancer or diverticulitis. It compared two pain management methods: a TAP block (injection of numbing medicine into the abdominal wall) and epidural anesthesia (medicine delivered near the…

This study tested a personalized rehabilitation program for 150 adults who finished treatment for colorectal cancer. The program connected patients with specialists like physiotherapists, dietitians, and psychologists based on their needs. The goal was to improve quality of life …

This study tested a bladder training method called ICCAUT in 400 adults who had rectal cancer surgery. The training involves clamping the urinary tube and practicing urination before removing the tube. The goal was to see if this reduces the need for a new catheter or incomplete …

This study looked at 60 adults with locally advanced rectal cancer to see if bacteria in their gut and mouth could predict how well they respond to chemotherapy and radiation before surgery. Researchers collected stool and saliva samples before treatment and used machine learning…

This study looked at 44 people with locally advanced rectal cancer to see if a special MRI measurement (T1 relaxation time) can accurately detect scar tissue after standard treatment. The goal was to find a non-invasive way to tell if the cancer had completely responded. Particip…

This study looked at 89 people with rectal or lower colon cancer to understand how blood flow changes after a common surgical step called high ligation. Researchers used CT scans before and after surgery to map blood vessel paths and check if their planned routes matched reality.…

This study tested whether a new type of PET scan (FAPI-PET/CT) can accurately tell if rectal cancer has been completely eliminated by chemoradiotherapy. Researchers enrolled 52 patients with a specific type of rectal cancer (MSS) to compare scan results with actual tissue samples…

This study followed 65 rectal cancer patients who had a second surgery to reconnect their bowel after tumor removal. Researchers used a standard questionnaire to measure bowel symptoms and their impact on quality of life one year later. The goal is to identify which patients may …

This study tested whether checking the removed tissue during surgery (frozen section) helps ensure all cancer is removed in people with mid or low rectal cancer who had radiation therapy before surgery. About 99 participants were split into two groups: one had the extra tissue ch…

This study tested a method called microdialysis to see if it can quickly find dangerous leaks after rectal cancer surgery. 21 patients who had rectal surgery were monitored with a small probe. The goal was to catch leaks early, before they cause serious harm.

This study explored whether a special ultrasound (dynamic contrast-enhanced ultrasound) can predict how well rectal cancer responds to chemotherapy and radiation. The goal is to identify good responders who might safely avoid major surgery and instead have a less invasive procedu…

This study tested whether an educational session at a church could help Spanish-speaking Latinos learn more about colorectal cancer and feel more willing to join cancer clinical trials. Sixty adults attended a session with videos and questionnaires, and 20 also gave one-on-one in…

This study looked at 57 people with rectal cancer to compare three different treatment approaches before surgery: a short course of chemotherapy and radiation (RAPIDO), standard long-course radiation, and surgery alone. The goal was to see how each approach affected the surgery i…

This study followed 107 adults newly diagnosed with rectal cancer to understand how their symptoms, balance, and quality of life change over time. Researchers used questionnaires to track bowel function, emotional distress, and fall risk. The goal was to learn more about patient …

This study tested a 12-week web-based diet program with text messaging for 50 colorectal cancer survivors. The goal was to see if the program was easy to use and could help people eat more vegetables, whole grains, and fish while cutting back on red meat and sugary drinks. All pa…

This study looked at 70 people with colorectal cancer to see how common muscle loss (sarcopenia) is before surgery and whether it affects recovery. Researchers measured muscle strength, mass, and physical performance before surgery, then tracked complications and hospital stay le…

This study tested whether a special DNA test (epigenetics multi-omics sequencing) can predict how well immunotherapy works for people with stomach or rectal cancer. 189 patients took part. The goal was to see if the test could tell who would have a complete response to treatment.…

This study looked at 3500 rectal cancer patients who had minimally invasive surgery to save their sphincter. Researchers tested seven different computer models, including six machine learning methods, to see which best predicts a condition called low anterior resection syndrome (…