RECTAL CANCER

This study looks at whether giving a strong chemotherapy combination called FOLFIRINOX before surgery can help more people with mid or low rectal cancer that has spread to the liver have successful removal of all tumors. About 550 adults will take part. The main goal is to see ho…

This study tests whether a shorter course of radiation combined with chemotherapy and an immunotherapy drug (serplulimab) can help people with high-risk locally advanced rectal cancer achieve complete remission before surgery. About 165 adults with a specific type of rectal cance…

This study tests whether an injectable drug called IP-001, given right after standard heat-based liver tumor ablation, can help prevent colorectal cancer from coming back in the liver or spreading elsewhere. About 717 adults with colorectal cancer that has spread only to the live…

This study tests whether a short course of radiation followed by the drug ivonescimab can make rectal tumors disappear in people with a specific genetic type (pMMR/MSS) of mid-to-low rectal cancer. About 30 adults who have not had prior treatment will receive radiation for 5 days…

This study tests whether giving chemotherapy after surgery can prevent rectal cancer from returning in people at high risk. Participants must have a positive blood test for cancer DNA after their tumor is removed. About 103 adults will be randomly assigned to receive either stand…

This study tests whether a short course of radiation, while keeping certain lymph nodes intact, followed by an immunotherapy drug (PD-1 inhibitor) can completely eliminate rectal cancer before surgery. It involves 44 adults with stage II-III rectal cancer. The goal is to see if t…

This study tests a new device called the Maastro applicator, which delivers high-dose radiation directly to rectal tumors. The goal is to destroy the cancer without needing surgery, which can have serious side effects. About 20 adults with rectal cancer will receive this treatmen…

This study tests a new approach for people with locally advanced HER2-positive rectal cancer. Participants first receive short-course radiation, then a combination of three drugs: disitamab vedotin, sintilimab, and capecitabine. The goal is to see if this treatment can completely…

This study tests a combination of two types of radiation therapy for elderly or frail patients with rectal cancer who cannot have or refuse surgery. The goal is to see if this approach can completely control the tumor for at least a year, while also monitoring quality of life. Ab…

This study tests whether adding an experimental drug (DCSZ11) to standard radiation and chemotherapy can improve outcomes for people with a high-risk type of rectal cancer. About 30 adults with mismatch repair proficient (pMMR) locally advanced rectal cancer will receive the comb…

This study tests whether adding an immunotherapy drug (Serplulimab) to standard chemotherapy before surgery can help people with a certain type of advanced rectal cancer. About 128 adults will be split into two groups: one gets the drug combo, the other gets chemo alone. The goal…

This study looks at people with locally advanced rectal cancer who have small leftover spots in the rectum after chemoradiation. Doctors want to see if removing these spots with a scope (endoscopic resection) leads to better 1-year cancer control than simply watching them closely…

This study tests whether using a patient's own gut bacteria (autologous probiotics) can reduce severe bowel problems after temporary ileostomy reversal in rectal cancer survivors. About 40 adults who had rectal cancer surgery with a temporary ileostomy will receive their own cult…

This study tests a new treatment approach for people with high-risk locally advanced rectal cancer. It combines a short course of radiation (with a boost to the tumor) along with chemotherapy and an immunotherapy drug before surgery. The goal is to see if this combination can com…

This study is for people with early-stage rectal cancer. It tests whether using chemoradiotherapy (a combination of chemotherapy and radiation) can completely eliminate the tumor, allowing patients to safely avoid surgery and keep their rectum. Participants can choose between sta…

This study tests whether a newer type of PET/MRI scan (using a tracer called FAPI) is better than the standard scan (using FDG) at finding cancer that has spread to lymph nodes in people with middle to high rectal cancer. About 30 patients who have not yet been treated will get b…

This study tests whether a highly absorbable form of curcumin (BCM-95) can reduce severe gut side effects like diarrhea and rectal pain in 72 adults with mid-to-low rectal cancer who are receiving chemoradiotherapy before surgery. Participants will take curcumin capsules daily du…

This study tests if a home-based exercise program can help people with stomach, esophagus, pancreas, colon, rectal, or lung cancer better tolerate chemotherapy. About 120 adults will be randomly assigned to either an aerobic and resistance exercise program or a stretching program…

This study looks at the best time to remove urinary catheters after surgery for mid-low rectal cancer. About 1,545 patients will be randomly assigned to have their catheter removed at 24 hours, 48 hours, or based on a personalized risk score. The goal is to see which approach red…

This study is for people with a certain type of rectal cancer that hasn't spread. Researchers want to see if a simple blood test that looks for tumor DNA can help track the cancer and find if it comes back earlier than usual scans. About 60 participants will give blood and tissue…

This study tests a short camera called a rectoscope to check the lower bowel after rectal tumor or polyp removal. The goal is to see if it can be used in the clinic with a simple enema instead of strong bowel prep, making follow-up exams easier and faster. Thirty patients will ta…

This study looks at tumor samples from 300 people who had surgery for rectal cancer. Researchers want to find out why some patients respond well to chemotherapy or immunotherapy while others do not. By studying the immune cells and other features inside the tumors, they hope to d…

This study looks at where cancer spreads to lymph nodes in people with colorectal cancer. Researchers will track 1,200 patients for at least 5 years after surgery to map these patterns. The goal is to help doctors better understand and treat the disease in the future.

This study aims to develop a method using advanced MRI scans to predict whether rectal cancer has been completely eliminated after chemoradiotherapy. About 115 adults with locally advanced rectal cancer will participate. The goal is to identify patients who could safely avoid maj…

This study tests whether a sensitive blood test (ctDNA) can help doctors decide the best treatment for people with early-stage rectal cancer. About 200 participants will either have standard treatment or have their treatment guided by the blood test results. The goal is to see if…

This study tests whether a new AI system can find tiny amounts of cancer left behind after treatment (called minimal residual disease) earlier than current methods. It will involve 700 adults with rectal or esophageal cancer who are scheduled for surgery. The AI combines blood te…

This study looks back at medical records of 300 adults who had rectal tumors removed between 2015 and 2025. Researchers want to see if newer endoscopic techniques (using a scope through the anus) are as safe and effective as standard abdominal surgery for early-stage rectal cance…