Could a chemo cocktail wipe out rectal cancer before surgery?
NCT ID NCT03997435
First seen Nov 17, 2025 · Last updated May 24, 2026 · Updated 24 times
Summary
This study tests whether adding a stronger chemotherapy regimen (FOLFOXIRI) to standard chemoradiotherapy helps eliminate more cancer before surgery in people with high-risk locally advanced rectal cancer. About 72 participants will receive either standard treatment or the intensified combination. The main goal is to see how many achieve a complete response, meaning no cancer cells remain in the removed tissue.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Department of Clinical Oncology, Queen Mary Hospital
Hong Kong, Hong Kong
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Department of Oncology, Princess Margaret Hospital
Hong Kong, Hong Kong
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The Chinese University of Hong Kong
Hong Kong, Hong Kong
Conditions
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