PAIN, CHRONIC

This study looks at whether a spinal cord stimulator can reduce pain and improve blood vessel health in people with type 2 diabetes who have nerve pain in their legs. About 25 adults with diabetes for over a year and poor circulation will get the device. Researchers will check pa…

This study tests whether a stellate ganglion block (a nerve injection in the neck) given before mastectomy can prevent depression and chronic pain after surgery. About 140 women with breast cancer will receive either the block or standard care. The goal is to see if this simple p…

This study tests whether giving the numbing drug lidocaine through a vein during breast cancer surgery can prevent persistent pain that often lasts for months after the operation. About 1,600 adults having a lumpectomy or mastectomy will be randomly assigned to receive either lid…

This study tests two experimental drugs (siltuximab and erenumab-aooe) to see if they can safely reduce chronic pain in people with schwannomatosis, a rare condition that causes painful nerve tumors. About 40 adults with moderate-to-severe pain will receive either the drug or a p…

This study tests whether a small, home-used device that gently stimulates a nerve in the ear can help young adults (ages 18-29) with irritable bowel syndrome (IBS) manage their pain and other symptoms. About 80 participants will use either the active device or a sham (fake) versi…

This study tests whether avoiding opioids during breast cancer surgery can reduce side effects like nausea and breathing problems, while still controlling pain. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard …

This study tests a method called cryoneurolysis, which uses a small tool to freeze the nerves that cause pain from broken ribs. The goal is to see if this approach is practical and can reduce pain and complications. 24 adults with broken ribs will receive this treatment alongside…

This study tests whether using opioid-free anesthesia during mastectomy can lower the chance of chronic pain one year after surgery. Researchers will compare this approach to standard opioid-based anesthesia in 230 breast cancer patients. Participants will be randomly assigned to…

This study is testing a mobile app called Diet4painrelief that gives personalized nutrition advice to people with chronic pain who are also overweight. About 200 adults will either get standard pain rehab or rehab plus the app. Researchers will check if the app helps improve pain…

This study compares two online programs for people with chronic pain: an 8-week cognitive behavioral therapy course (16 hours total) and a single 2-hour pain relief skills class. Researchers want to see which approach works better for reducing pain intensity and improving daily l…

This study tests a new approach called Pain Reprocessing Therapy (PRT) for adults with ongoing knee pain after knee replacement surgery. PRT teaches the brain to reinterpret pain signals, aiming to reduce pain without medication. About 110 participants will be randomly assigned t…

This study looks at how pain pathways in the brain and nerve regrowth in the eye change after corneal crosslinking (CXL) for keratoconus. Researchers will use brain scans (fMRI) and special eye imaging to measure these changes in 60 participants aged 8-35. The goal is to better u…

This study looks at how teenagers with chronic pain notice and understand signals from their own bodies, like heartbeat or tension. Researchers want to see if occupational therapy changes this body awareness and improves daily function. About 49 teens aged 11 to 21 will fill out …

This study looks at whether taking prescription opioids for chronic pain is linked to changes in the brain's white matter in adults aged 65 and older. Researchers will use MRI scans to measure brain structure in 200 participants over time. The goal is to better understand the lon…

This study looks at sleep patterns in 20 teenagers aged 15-17 who have had pain for more than 3 months. Researchers will test a relaxation technique done before sleep to see if it improves sleep quality and helps the brain process emotions tied to pain. Participants sleep at home…

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to spot signs of pain and how to talk about it with doctors. About…

This study follows 20,000 adolescents aged 12-17 who receive opioid painkillers after major surgery. Researchers want to identify early warning signs that could lead to opioid use disorder within the first year. Participants complete surveys and allow access to their medical reco…

This study looks at a telephone service called SUSTAIN that helps older adults (65+) manage depression, anxiety, or chronic pain. Researchers want to find out what factors make the program more effective and whether its benefits last over time. About 4,000 participants will be fo…