PAIN, CHRONIC

This study tests whether Pain Reprocessing Therapy (PRT) works better than Cognitive Behavioral Therapy (CBT) or usual care for adults with chronic back pain. About 150 diverse participants will try one of the three approaches. The goal is to see which treatment lowers pain and i…

This study planned to test whether virtual reality guided mindfulness meditation could help adults with anxiety, depression, stress, and pain. Participants would have used a VR headset to meditate, and researchers would measure changes in their symptoms. However, the study was wi…

This study aimed to see if the Sana device could improve quality of life and reduce pain in people with fibromyalgia. It planned to compare the active device to a sham (fake) device in about 100 adults aged 18 to 65 who had fibromyalgia symptoms for at least 3 years. However, the…

This study tests a non-drug treatment—hypnosis combined with cognitive therapy—for people with new spinal cord injuries who have moderate to severe pain. Participants receive either four sessions of this therapy or four sessions of pain education during their hospital rehab stay.…

This study tests whether cognitive behavioral therapy (CBT) can be delivered in virtual group sessions to help adults with cerebral palsy cope with chronic pain. Researchers will enroll 14 participants to see if the approach is practical and well-received. The goal is to reduce p…

This study tests a resilience coaching program called PRISM for teens aged 12-17 with chronic muscle or joint pain lasting at least 3 months. The goal is to see if coaching improves daily function, reduces distress, and eases pain compared to usual care. About 260 teens and a par…

This study tests whether virtual reality (VR) meditation can help people with long-term pain and insomnia. About 30 adults with both conditions for at least 6 months will use VR meditation and track their sleep, pain, and mood. The goal is to see if this approach can reduce anxie…

This study looks at whether a type of pain education, combined with motivational interviewing, can reduce long-term pain in breast cancer survivors who feel their pain is unfair or unjust. About 156 women who have finished primary cancer treatment and have chronic pain will take …

This study compares two minimally invasive procedures—laparoscopic presacral neurectomy and fluoroscopically guided nerve block—to reduce chronic pelvic pain in adults with pelvic cancer. Sixty-two participants will be randomly assigned to one of the two treatments, and neither t…

This study aims to find biological markers (biomarkers) that can tell whether a person with long-term muscle or joint pain will recover or develop lasting disability. Researchers will follow 250 adults with chronic musculoskeletal pain, using questionnaires and possibly imaging t…

This study follows 275 teens aged 11–18 with chronic muscle or joint pain to learn why some get better and others don't. Researchers measure pain levels and daily function over time, looking for biological and behavioral clues. No new treatment is tested—the goal is to better und…