NEOADJUVANT THERAPY

This study tests whether a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus a targeted therapy (lenvatinib) can shrink kidney tumors enough to allow safe, kidney-sparing surgery in patients who otherwise would need full kidney removal. About 25 adults wi…

This study tests whether adding radiotherapy to a combination of chemotherapy (CAPOX) and an immunotherapy drug (Toripalimab) can improve outcomes for people with locally advanced rectal cancer that is microsatellite stable. About 192 participants will receive either the drug com…

This study is testing whether giving two drugs (sintilimab and bevacizumab) before surgery can help prevent liver cancer from coming back in people whose cancer has spread beyond the usual Milan criteria. About 37 adults with resectable liver cancer will receive the drug combinat…

This study tests whether giving a combination of envafolimab (an immunotherapy) and two chemotherapy drugs before surgery can help shrink tumors in people with locally advanced esophageal cancer. About 26 adults with operable disease will receive the treatment and then have surge…

This study tests whether women with breast cancer whose armpit lymph nodes appear cancer-free on ultrasound after chemotherapy can safely avoid surgery to remove those nodes. Half the participants will skip armpit surgery, while the other half will have the standard sentinel node…

This study tests whether adding a probiotic called Probio-M9 to standard chemoradiation and immunotherapy can help shrink tumors more effectively in people with locally advanced rectal cancer. About 50 adults with stage II or III rectal cancer will be randomly assigned to receive…

This early-phase trial tests a new combination of the immunotherapy drug tislelizumab plus standard chemotherapy (FLOT) given before surgery for patients with resectable stomach, esophageal, or gastroesophageal junction cancer. The goal is to see if this approach is safe and effe…

This study tests a new treatment plan for people with a specific type of lung cancer (KRAS G12C mutation) that can be removed with surgery. Before surgery, patients receive a targeted drug (fulzerasib) for 6 weeks, then a break, followed by 3 cycles of immunotherapy (sintilimab) …

This study tests whether a treatment plan called total neoadjuvant therapy (TNT) can help about half of rectal cancer patients avoid surgery and keep their rectum. Participants receive chemotherapy and radiation before deciding if they need surgery. Those who respond very well ar…

This study tests two different treatment plans for people with locally advanced rectal cancer that has not spread. One plan uses longer radiation followed by chemotherapy, while the other uses shorter radiation plus chemotherapy, an immunotherapy drug, and a painkiller that may h…

This study tests whether adding radiation to a mix of chemotherapy and two immunotherapy drugs before surgery can improve outcomes for people with resectable stomach or gastroesophageal junction cancer. About 40 adults with HER2-negative disease will be randomly assigned to recei…

This study tests whether giving two drugs (pucotenlimab and vorolanib) before surgery can shrink kidney tumors enough to allow partial kidney removal instead of full removal. About 21 adults with high-risk clear cell renal cell carcinoma will receive the drug combination for seve…

This study is for people with a specific type of colorectal cancer (dMMR/MSI-H) that hasn't spread far. It tests giving an immunotherapy drug (toripalimab) with or without an anti-inflammatory drug (celecoxib) before surgery. The goal is to see if this approach can shrink or elim…

This study tests if a special PET scan (FAPI-PET) and a fluorescent dye can help doctors find leftover lung cancer during surgery after standard treatment. About 200 people with stage II-IIIB non-small cell lung cancer will get the scan and dye before and during surgery. The goal…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. About 172 participants will be randomly…

This study tests a digital therapy that combines music and biofeedback to help women with advanced breast cancer sleep better and feel less anxious or depressed while undergoing chemotherapy before surgery. About 66 participants will be randomly assigned to either receive the dig…

This study looks at whether proteins in urine can help doctors predict how patients with advanced colorectal cancer will respond to treatment before surgery. Researchers will collect urine samples from 400 participants and use advanced technology to find protein patterns linked t…

This study is testing whether a computer model that looks at many types of patient data can predict how well pre-surgery treatment works for non-small cell lung cancer. Researchers will study 500 people receiving chemo-immunotherapy before surgery. The goal is to improve treatmen…

This study is developing a new, non-invasive way to monitor lung cancer patients after surgery using blood tests and artificial intelligence. Researchers will analyze blood samples from 100 patients who have had surgery and chemotherapy to look for signs of cancer returning. The …

This study is looking at small molecules called microRNAs in the blood of 80 women with breast cancer who are about to start chemotherapy. Researchers will measure these molecules before and after treatment to see if changes can predict how well the cancer responds. The goal is t…

This study looks at how chemotherapy or radiation before surgery (neoadjuvant therapy) affects small blood vessels and tissue stiffness in colorectal cancer patients. Researchers will compare 34 patients who had pre-surgery treatment with 34 who went straight to surgery. The goal…

This study looks at 400 people with non-small cell lung cancer who had pre-treatment (like chemo or immunotherapy) and then needed a specific type of lung surgery called sleeve lobectomy. Researchers want to see if a less invasive surgery (using small cuts and a camera) works as …