METASTATIC COLORECTAL CANCER

This study is testing whether adding two targeted drugs (sotorasib and panitumumab) to standard chemotherapy works better than standard chemotherapy alone for people with advanced colorectal cancer that has spread and has a specific genetic change called KRAS G12C. The trial will…

This study is testing an experimental drug called enfortumab vedotin for people with advanced colorectal cancer or liver cancer that has spread and has not responded to standard treatments. The goal is to see if the drug can shrink tumors and control the cancer. The trial will en…

This study is testing whether two new drugs, BNT314 and BNT327, can help the body's immune system fight cancer when given alongside standard chemotherapy. It is for people with metastatic colorectal cancer that has spread and is not responding well to initial treatments. The main…

This study is observing how a biosimilar version of the cancer drug bevacizumab works in real-world treatment of advanced colorectal cancer in Brazil. Researchers will follow 133 adult patients with metastatic colorectal cancer who are receiving this drug as part of their first-l…

This early-stage study is testing whether personalized drug combinations can help control advanced colorectal cancer that has spread. Researchers will match patients to specific treatment arms based on genetic markers found in their tumors. The goal is to find safe and effective …

This early-stage trial is testing new combinations of targeted drugs for people with advanced colorectal cancer that has spread and cannot be surgically removed. The study aims to find safe doses of a new drug called ulixertinib when given with other cancer medications to patient…

This study is testing whether an experimental drug called RBS2418, which aims to boost the immune system's ability to fight cancer, can help control advanced colorectal cancer. It will involve about 150 adults whose cancer has continued to progress despite trying all standard tre…

This study is testing an experimental drug called ivonescimab in people with metastatic colorectal cancer that has stopped responding to standard treatments. Ivonescimab is designed as a single drug that targets two different pathways cancer uses to grow and evade the immune syst…

This study is testing whether combining the drugs fruquintinib and tislelizumab works better than standard therapy for people with a common, hard-to-treat type of advanced colorectal cancer that hasn't spread to the liver. About 140 participants will be randomly assigned to recei…

This is an early-stage trial testing a new, personalized immune cell therapy for people with metastatic colorectal or prostate cancer. Doctors take a patient's own tumor-fighting immune cells, grow large numbers of them in a lab, and give them back to the patient multiple times. …

This trial is testing a new combination of chemotherapy drugs for people with a specific type of advanced colorectal cancer that has spread. The treatment is designed for patients whose tumors have certain genetic features. The main goals are to find the safest dose and see if th…

This study is testing a new combination of four immunotherapy drugs for people with metastatic colorectal cancer that has spread and stopped responding to standard treatments. The goal is to see if this multi-drug approach can help the body's immune system fight the cancer more e…

This study is testing whether a combination of three drugs—adagrasib, cetuximab, and cemiplimab—can help control metastatic colorectal cancer that has a specific genetic change called a KRAS G12C mutation. The trial aims to see how well the treatment works and how safe it is for …

This study is testing whether adding an experimental drug called telisotuzumab adizutecan to standard chemotherapy works better for people with metastatic colorectal cancer. About 390 adults worldwide will receive different combinations of these drugs to find the safest and most …

This study is testing a new oral drug called ART0380 in people with advanced or metastatic solid tumors that have spread and are hard to treat. The main goals are to find the safest and most effective dose of ART0380 when given alone or combined with standard chemotherapy drugs, …

This study is testing two different dosing schedules of an experimental drug called EMB-01 for people with advanced colorectal cancer that has returned or spread after previous treatments. About 54 participants will be randomly assigned to receive weekly injections or a schedule …

This study is testing whether adding a new immunotherapy drug (volrustomig) to standard chemotherapy works better for people with advanced colorectal cancer that hasn't spread to the liver. The trial will compare the safety and effectiveness of the new combination against standar…

This study compares two different drug combinations for people with advanced colorectal cancer that has spread and cannot be surgically removed. Researchers want to see if adding a newer immunotherapy drug (envafolimab) to standard chemotherapy and targeted therapy helps control …

This is the first human study testing a new experimental drug called BBO-10203 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goal is to find safe doses and see how the body processes the drug, both alone and when combined with oth…

This study tests whether a patient's own immune cells, removed from their tumor and multiplied in a lab, can shrink tumors when given back alongside the drug pembrolizumab. It's for adults with advanced digestive tract, breast, ovarian, or other cancers that have spread and stopp…

This study is testing a different chemotherapy combination for people with advanced colorectal or stomach cancer who have a specific enzyme deficiency (DPD deficiency). This deficiency makes standard chemotherapy drugs too toxic. Researchers want to see if this new combination is…

This early-stage study is testing a new type of CAR-T cell therapy for people with metastatic colorectal cancer that has not responded to standard treatments. Instead of using the patient's own cells, this 'universal' therapy uses modified immune cells from healthy donors. The ma…

This study is testing if adding an existing drug called sodium valproate (used for epilepsy) to standard maintenance cancer drugs helps people with a specific type of advanced colorectal cancer live longer without their cancer getting worse. It will involve about 90 adults whose …

This study compares two different drug combinations for people with advanced colorectal cancer that has spread. Researchers want to see if using a simple blood test to guide treatment decisions helps control cancer growth better. The trial will enroll 280 adults who haven't recei…

This study is creating a new mindfulness program called 'MIND-Together' to help couples where one partner has metastatic colorectal cancer. Researchers are interviewing patients, their partners, and clinicians to design a 4-session video program that addresses their specific emot…

This study aims to collect real-world treatment and survival information from 400 patients with metastatic colorectal cancer that has a specific BRAF gene mutation. Researchers will gather medical records and biological samples during normal cancer care to better understand how t…

This study aims to understand what treatment options doctors choose for patients with advanced colorectal cancer after their initial chemotherapy stops working. It will follow 1,000 patients to see which subsequent treatment approaches are most common and how well patients do wit…