LONG COVID

This study offers expanded access to an infusion of human umbilical cord blood (REGENECYTE) for adults with Long COVID who are not eligible for other clinical trials. The goal is to see if this treatment can help control ongoing symptoms like chronic fatigue. Participants must ha…

This study tests whether anakinra, a drug that calms the immune system, can help people with long COVID who still have breathing problems and signs of inflammation. About 182 adults will receive either anakinra or a placebo for up to 8 weeks. The goal is to see if the drug improv…

This study tests whether baricitinib, an anti-inflammatory drug, can improve thinking, memory, and physical symptoms like fatigue and shortness of breath in people with Long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placeb…

This study tests a treatment called immunoadsorption for people with long COVID whose immune system may be attacking their own body. The treatment filters the blood to remove harmful antibodies. About 70 participants will receive either the real treatment or a placebo, and resear…

This early-stage study tests lumbrokinase, an enzyme that breaks down blood clots, in 120 adults with Long COVID, post-treatment Lyme disease syndrome, or ME/CFS. Participants rate their overall health before and after treatment to see if the enzyme improves quality of life. The …

This study tests whether two existing medications (upadacitinib and pirfenidone) can improve Long Covid symptoms like fatigue, breathing trouble, brain fog, muscle pain, and circulation issues. About 348 adults from six countries who have had Long Covid for at least three months …

This study tests whether two HIV medications, Truvada and Selzentry, can reduce symptoms in adults with Long COVID. Participants will take one of the drugs or a placebo daily for 90 days. The goal is to see if these antivirals help improve overall health and quality of life.

This study tests whether mind-body techniques—like relaxation or meditation—can reduce Long COVID symptoms such as pain, fatigue, and dizziness. Researchers will compare these techniques to usual care in 180 adults who have had COVID-19 and still feel sick for at least 3 months. …

This study tests whether plitidepsin, a drug previously used for cancer, can help people with long COVID. About 90 adults with moderate to severe long COVID symptoms will receive either the drug or a placebo through an IV over several weeks. Researchers will measure changes in ov…

This small pilot study is testing whether acupuncture, alone or with Chinese herbal medicine, can help ease long COVID symptoms like fatigue and brain fog. Ten adults with long COVID will receive 16 acupuncture sessions over 8 weeks, with half also taking herbal supplements. The …

This study tests a device called Hi-OxSR that lets people briefly rebreathe their own carbon dioxide. Early results suggest it may reduce brain fog and fatigue in people with Long COVID. The trial will enroll 120 adults to find the best dose and check safety.

This Mayo Clinic pilot study tests whether controlled changes in oxygen and carbon dioxide levels can help people with long COVID brain fog. The study will measure brain blood flow, heart rate, and symptom changes in 45 participants. It aims to find a safe, non-invasive way to ea…

This study tests if a gentle ultrasound pulse to a specific brain area can improve thinking and memory in people with long COVID brain fog. 40 participants who have had brain fog for at least 4 weeks after COVID will receive either real or fake ultrasound. The goal is to see if t…

This study tests two at-home treatments—smell training and a gentle nerve stimulation device—to help people with long COVID who have lost or distorted their sense of smell. About 145 adults will do daily sessions for 12 weeks and attend three clinic visits. The goal is to see if …

This study tests whether taking taurine supplements can reduce brain fog, fatigue, and other thinking and memory problems in people with Long COVID. Researchers will enroll 300 adults who had COVID-19 at least 3 months ago and still have symptoms. Participants take taurine or a p…

This study tests whether the drug bezisterim (NE3107) can improve thinking, memory, and energy in adults with long COVID. About 208 people will take either the drug or a placebo twice a day for 84 days. The goal is to see if it helps with brain fog and fatigue that started or got…

This study tests whether a drug called Anktiva is safe and tolerable for people with Long COVID. About 20 adults aged 18 to 69 who have had COVID-19 will receive up to two doses. Researchers will monitor side effects and check if symptoms improve using questionnaires.

This study tests whether an 8-week program of supervised physical and mental exercises can improve daily function, thinking, and quality of life in adults with Long COVID who also have high blood pressure or diabetes. About 374 participants will be randomly assigned to either the…

This study tests whether two medications—Pyridostigmine and Low-Dose Naltrexone—can improve daily functioning in people with ME/CFS or Long COVID who also have orthostatic intolerance (trouble standing). 160 adults aged 18-70 will be randomly assigned to take one or both drugs or…

This study tests if using heat packs on the legs at home can help older adults (ages 50-90) with long COVID feel better and move more easily. Researchers will measure walking distance, physical function, and blood vessel health. The goal is to find a simple, safe way to improve d…

This study tests the safety of a drug called NAI (Anktiva) in 40 adults aged 18 to 70 who have Long COVID — meaning they still have symptoms after a confirmed COVID-19 infection. The main goal is to check for side effects and changes in vital signs over 30 days after treatment. I…

This study tests a medicine called DAOIB to see if it can help with memory and thinking problems caused by long COVID. About 40 adults with long COVID and brain fog will take DAOIB for 24 weeks. Researchers will check their thinking skills, mood, and quality of life every 8 weeks…

This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can ease lingering COVID-19 symptoms like brain fog and fatigue. About 120 adults with long COVID will receive the treatment, and researchers will track changes in thinking speed a…

This study tests a gentle brain stimulation method called rTMS to see if it can reduce severe fatigue and concentration problems in adults with long COVID. 66 participants will receive either real or placebo rTMS over six weeks. The goal is to improve energy and thinking by targe…

This pilot study tests whether whole body hyperthermia — a sauna-like treatment — can reduce fatigue and other symptoms in people with Long COVID. Researchers at Massachusetts General Hospital will enroll 21 adults aged 18-65 who had COVID-19 at least 12 weeks prior. Participants…

This study compares two 30-hour cognitive rehab programs for 30 adults with long COVID who have mild to moderate brain fog. Both programs use computer games, in-person training, and a mild nerve stimulation device. One program focuses on thinking skills and work tasks, while the …

This study tests whether a stellate ganglion block—a numbing injection near nerves in the neck—can improve long COVID symptoms like fatigue, brain fog, and trouble breathing. About 40 adults with persistent symptoms for at least 3 months will receive either the real injection or …

This study looks at why some people develop depression after a mild or moderate COVID-19 infection. Researchers will use brain scans to compare brain activity in 90 adults who have new depression after COVID-19. The goal is to better understand the brain changes involved, not to …

This study aims to understand why some people, mostly women, develop a fast heart rate and other symptoms like fatigue and brain fog after COVID-19. Researchers will measure immune system activity and nerve function in 60 participants. The goal is to find the cause, not to test a…

This study looks at why some veterans experience brain fog and other mental health issues after COVID-19. Researchers will track 200 veterans over time, using memory tests and blood samples to find clues. The goal is to better understand these long-term symptoms and identify targ…

This study aims to understand the short- and long-term health problems that can occur after a COVID-19 infection, including damage to the heart, lungs, kidneys, and other organs. Researchers will follow 650 adults in Quebec, including people who had mild or severe COVID-19, those…

This study is looking at whether a special radioactive tracer can detect brain inflammation in people with long COVID who have symptoms like headaches, memory problems, or depression. Researchers will compare brain scans of 60 adults (ages 18-70) who have long COVID with healthy …

This study collects health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a phone app to share symptoms, wearables data, and lifestyle details. The goal is to help researchers better understand these illness…

This study looks at 400 adults who had COVID-19 and are now preparing for surgery. Researchers want to understand what long-term symptoms they still have, like breathing problems or tiredness. No new treatments are given—just questionnaires and medical record checks. The goal is …

This study compares how the brain controls reproductive hormones in people with and without Long COVID. Participants receive a single dose of kisspeptin, a natural hormone, and researchers measure hormone levels through frequent blood draws. The goal is to understand if Long COVI…

This study looks at whether special rehabilitation therapies can help older Veterans recover from Long-COVID by improving blood vessel function. It involves 300 participants aged 50 and older who are 3-12 months past their COVID-19 diagnosis. The goal is to find safe, effective w…

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will measure immune cells and inflammati…

This study looks at how tiny structures inside cells called mitochondria use oxygen to make energy. Researchers want to see if this process is different in people with long COVID compared to those who fully recovered. About 54 adults will wear activity trackers, answer surveys, a…