LONG COVID

This study tests whether a combination of anti-inflammatory and heart-protecting drugs can reduce symptoms and prevent heart damage in people with Long COVID. About 279 adults with ongoing heart symptoms and signs of heart inflammation on MRI will receive either the drug combo or…

This study planned to test a blood-filtering device called Seraph 100 in 100 adults with long COVID. Participants would receive two filtering sessions on consecutive days and be checked after 3 days and 4 weeks. However, the study was withdrawn before any patients were enrolled, …

This study tests whether sirolimus, a drug used to prevent organ rejection, can reduce the risk of lung scarring (fibrosis) in people hospitalized with severe COVID-19 pneumonia. About 60 adults will receive sirolimus to see if it prevents long-term lung damage. The goal is to im…

This study looks at whether low-dose rapamycin can reduce symptoms and improve quality of life in people with ME/CFS or Long-COVID. Researchers will track 150 participants through questionnaires and blood tests to see how the drug affects fatigue and daily function. The goal is t…

This study tests whether the antiviral drug ensitrelvir can help people with long COVID by targeting leftover virus in the body. About 40 adults with long COVID symptoms will receive either the drug or a placebo for 10 days. The main goal is to see if the drug improves physical h…

This study is testing a new, non-invasive diagnostic method for Long COVID. It uses electroacupuncture-based medicament testing to detect bioelectrical patterns that may indicate persistent viral antigens. The study will enroll 50 adults with confirmed Long COVID symptoms lasting…

This study tests whether a lab-made antibody called AER002 can safely help people with Long COVID feel better. Researchers think that leftover virus pieces in the body might cause Long COVID, and this antibody aims to target them. The trial involves 36 adults who receive either t…

This study tests a type of talking therapy called Balance ACT to see if it improves quality of life for people with long COVID. About 196 adults with long COVID symptoms lasting over 12 weeks will either get the therapy or a self-help leaflet. The main goal is to measure physical…

This pilot study tests whether low-dose ketamine can reduce fatigue and improve thinking in people with Long COVID. Twenty adults aged 18-65 with ongoing tiredness or brain fog will receive four ketamine injections over two weeks. Researchers will track symptom changes, brain sca…

This study tests whether the drug larazotide can safely reduce Long COVID symptoms in 107 people aged 7 to 50. Participants take either the drug or a placebo four times a day for 21 days. The goal is to see if the drug helps with symptoms like fatigue, brain fog, and breathing tr…

This study looks at whether eating fermented foods like yogurt, sauerkraut, and kimchi can increase the variety of good bacteria in the gut and help ease long COVID symptoms such as fatigue, depression, and anxiety. About 40 adults with long COVID will track their food intake and…

This study tests different treatments to help people with Long COVID who have sleep problems like insomnia, daytime sleepiness, or irregular sleep patterns. About 470 adults will be randomly assigned to receive a treatment or a placebo. The goal is to see if these treatments can …

This study tests different treatments to help people with Long COVID who have trouble exercising or feel very tired after activity. It will include 360 participants and measure how well they can walk and perform daily tasks. The goal is to find safe ways to improve their quality …

This study tests whether tirzepatide (Zepbound), a medicine used for diabetes and weight loss, can reduce Long COVID symptoms like fatigue. About 1000 adults with Long COVID will take either the drug or a placebo for 12 months, and all tasks are done from home. The main goal is t…

This study is for people with Long COVID who have sleep issues like feeling very sleepy during the day or having trouble sleeping at night. Researchers will test different treatments to see which ones help improve sleep and reduce daytime tiredness. About 361 adults will take par…

This study looks at whether light, self-paced swimming is a safe and tolerable activity for people with ME/CFS and related conditions like Long COVID and POTS. Participants will use an app to track symptoms and heart rate before and after swimming. The goal is to understand how w…

This study aims to create a test that predicts how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and a national veterans' population, using both clinical data and molecular markers. The goal…

This study is observing 160 adults with Long COVID, Lyme disease, or ME/CFS to see if a special blood test can detect T cell dysfunction. Participants give blood samples and answer symptom questionnaires at the start and after 6 months. No treatments are tested—the goal is to bet…

This study aims to design and test rehabilitation strategies that combine physical and mental tasks (like walking while solving a puzzle) for people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will work with 48 participants to see if these dua…

This study looks at whether liraglutide (Saxenda®), a drug used for weight loss, can increase a brain-health marker called BDNF in people with multiple sclerosis, long-COVID, or leukemia (in remission) who also have obesity and memory or thinking problems. About 30 participants w…

This study looks at people with Long COVID who have new chest pain but no blocked arteries. It tests whether treatment based on special heart function tests works better than usual care. About 108 participants will be followed for a year to see if their symptoms and quality of li…

This study uses special MRI scans with inhaled gases to see how lungs work in people with asthma, COPD, or COVID-19 (including Long COVID). Researchers will track up to 160 participants over several years to understand how these diseases change the lungs over time. The goal is to…