LONG COVID

This study is testing whether a short course of an antiviral medication called ensitrelvir can help people with Long COVID feel better. About 40 adults with Long COVID symptoms lasting at least 60 days will take either the real pill or a placebo for 5 days. Researchers will measu…

This study is testing whether the drug sirolimus can prevent permanent lung scarring (fibrosis) in people hospitalized with severe COVID-19 pneumonia. Hospitalized patients will be randomly assigned to receive different doses of sirolimus or standard care alone. Researchers will …

This study is testing whether a combination of two existing drugs can protect the heart in people with Long COVID who have developed heart inflammation. Researchers will give 279 participants either the active medication or a placebo for 16 weeks to see if it reduces symptoms lik…

This study is testing whether a one-time infusion of a lab-made antibody (AER002) can help people with Long COVID feel better. About 30 adults with persistent symptoms after a COVID-19 infection will receive either the antibody treatment or a placebo. Researchers will track chang…

This study is testing a new, non-invasive diagnostic method for people with Long COVID. Researchers will use a single-session procedure that measures bioelectrical responses through the skin to look for patterns that might indicate persistent viral factors. The goal is to evaluat…

This small pilot study is testing whether ketamine, a medication used for anesthesia and depression, can help ease the fatigue and thinking problems (often called 'brain fog') experienced by people with Long COVID. Twenty adults with Long COVID will receive four ketamine injectio…

This study is testing a new rehabilitation approach where people practice mental and physical tasks at the same time. It aims to see if this 'dual-task' method improves walking, balance, thinking skills, and daily function for people with stroke, multiple sclerosis, Parkinson's d…

This study is testing a new physical therapy approach called Cognitive Muscular Therapy (CMT) to help people with Long COVID who have trouble breathing. The therapy uses a special system to show patients their breathing patterns in real-time while teaching them to relax overactiv…

This study is testing whether tailored light therapy or melatonin supplements can help people with Long COVID who are struggling with severe sleep problems like insomnia or daytime sleepiness. It's a Phase 2 trial involving 470 participants across multiple centers. The goal is to…

This study is testing different treatments to help people with Long COVID who get very tired and feel worse after even light exercise. It will enroll 360 participants across multiple centers to see if certain interventions can help them walk longer, do more daily activities, and …

This study is testing whether the medication tirzepatide (brand name Zepbound) can reduce symptoms of Long COVID, especially severe fatigue. It involves 1,000 adults in the U.S. with Long COVID who will be randomly assigned to take either the real medication or a placebo pill for…

This study is testing whether a psychological therapy called Balance Acceptance and Commitment Therapy (ACT) can improve quality of life for people with long COVID. Researchers are comparing the therapy against standard self-help information in 196 UK adults who have had COVID sy…

This study is testing different treatments to help people with Long COVID who struggle with severe sleep problems like extreme daytime sleepiness and insomnia. About 361 participants will be assigned to receive either an active treatment or a placebo based on their specific sleep…

This study aims to see if eating a diet high in fermented foods like yogurt, kefir, and kimchi can change the mix of bacteria in the gut (the microbiome) of people with long COVID. Researchers at Mayo Clinic will enroll 40 adults with long COVID and randomly assign half to eat 6+…

This study aims to understand why veterans with Long COVID experience such severe and persistent fatigue. Researchers are measuring muscle function and oxygen use to find the cause. They are also testing if a simple, once-a-week home exercise program is safe and feasible for this…

This study aims to understand if a specific problem with the body's immune T-cells is causing symptoms in people with long COVID, chronic Lyme disease, or ME/CFS (chronic fatigue syndrome). Researchers will observe 160 people, including healthy volunteers, by taking blood samples…