Could an antibody finally treat long COVID?
NCT ID NCT05877508
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single dose of the monoclonal antibody AER002 can safely improve physical health in adults with Long COVID. The idea is that lingering virus or spike protein may cause ongoing symptoms, and the antibody might clear it. 36 participants will receive either AER002 or a placebo, and their physical health will be measured using a standard questionnaire at 90 days.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- AER002 (a monoclonal antibody)
- What this could lead to
- If it works, this could point toward a treatment for Long COVID by targeting lingering virus or spike protein.
- What could go wrong
- This is a small, early-phase trial with only 36 people, so results may not apply broadly. The antibody only works against certain virus variants, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
36 people
The number who actually took part.
- Started
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Aug 2023
- Expected to finish
-
Jul 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Key Inclusion Criteria (note, additional eligibility criteria not listed here will be assessed at Screening): * Male, female, or transgender ≥18 years of age at Screening. * History of confirmed acute SARS-CoV-2 infection. * Long COVID attributed to a SARS-CoV-2 infection with a variant against which AER002 is known to have neutralizing activity (prior to August 15, 2022). Note: While individuals re-infected with SARS-CoV-2 after August 15, 2022 will not be excluded, the SARS-CoV-2 infection after which Long COVID symptoms began must pre-date August 15, 2022. * At least two symptoms that are new or worsened since the time of SARS-CoV-2 infection, not known to be attributable to another cause upon assessment by the PI. Symptoms must have been present for at least 60 days prior to screening and must be reported to be at least somewhat bothersome. * Body mass index (BMI) 18 to 50 kilograms/meter squared (kg/m2), inclusive, at the time of screening. * Participants who are of childbearing potential (CBP) and male participants with sexual partner(s) who are females of CBP must agree to use adequate contraception from study consent through 360 days after dosing. Key Exclusion Criteria (note, additional eligibility criteria not listed here will be assessed at Screening): * Long COVID attributed to a SARS-CoV-2 infection after August 15, 2022. * Previously received treatment or prophylaxis with a SARS-CoV-2-specific mAb, or plan to receive such treatment before exiting the study. * Previously received COVID-19 convalescent plasma treatment within 60 days prior to Day 0 or plan to receive such treatment before exiting the study. * Plans to receive any investigational or approved vaccine or booster for SARS-CoV-2 within 60 days prior to Day 0 or before Day 30 following Day 0. * Active cardiovascular disease or recent (within 3 months) stroke. * Recent (within 6 months) or planned major surgery. * Currently hospitalized or recent (within 1 month) unplanned hospitalization. * Active Hepatitis Bor C infection . * Untreated or unstable HIV infection (two or more consecutive plasma HIV RNA values \>48 copies/mL in the 6 months prior to screen). * Severe coagulopathy (international normalized ratio ((INR) \>2.0, history of hemophilia). * Severe anemia (hemoglobin \<9 grams/deciliter (g/dL)). * Moderate or severe immunocompromise, according to the current NIH COVID-19 Treatment Guidelines as of March 6, 2023. * History of anaphylaxis or hypersensitivity upon receiving IV antibody infusions, any componenets of the intervention, prescription or non-prescription drugs, or food products in the past. * Pregnant, breastfeeding, or unwilling to practice birth control abide by the contraception requirements outlined in the inclusion criteria. * Participation in a clinical trial with receipt of an investigational product within 28 days or 5 half-lives (whichever is longer) prior to Day 0. * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UCSF/Zuckerberg San Francisco General Hospital
San Francisco, California, 94110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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