INVASIVE BREAST CANCER

This study tests whether a daily pill (Z-endoxifen) plus a monthly shot (goserelin) can slow or stop tumor growth in premenopausal women with ER+/HER2- breast cancer. About 87 participants will take the combination for up to 24 weeks before surgery. The main goal is to see if the…

This study tests a drug called sacituzumab govitecan, given before surgery, in people with localized triple-negative breast cancer. The goal is to see if it can eliminate all signs of cancer in the breast and lymph nodes at the time of surgery. About 260 participants will receive…

This study tests two drugs, trastuzumab deruxtecan and durvalumab, given before surgery to people with stage III inflammatory breast cancer that has a protein called HER2. The goal is to see if the combination can eliminate all signs of cancer in the breast and lymph nodes at the…

This study is for people with advanced breast cancer (T3 or T4) who have responded well to chemotherapy. Instead of the usual approach of mastectomy, delayed reconstruction, and radiation after surgery, researchers are testing whether giving radiation before surgery allows for im…

This study looks at whether taking vitamin D during chemotherapy can help women with triple negative breast cancer and low vitamin D levels achieve a complete response (no cancer left after treatment). About 50 participants will receive standard chemotherapy plus vitamin D supple…

This study tests a drug called trastuzumab deruxtecan, which delivers chemotherapy directly to cancer cells with low HER2 levels, given alone or with anastrozole (a hormone blocker). About 88 people with early-stage, hormone receptor positive breast cancer will receive treatment …

This study tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice during thei…

This study collects tumor tissue and blood samples from 200 adults with breast cancer or precancerous breast conditions. Samples are taken during standard procedures like surgery, and researchers analyze them to identify biomarkers and genetic profiles. The goal is to better unde…

This study takes small tumor samples from 240 women with invasive breast cancer who are scheduled for chemotherapy before surgery. Researchers will grow these samples into mini-tumors (organoids) in the lab to study each tumor's unique features. The goal is to create models that …

This study tests whether a type of whole-body MRI (DWB-MRI) can detect the return or spread of breast cancer earlier than standard scans. Researchers will follow 145 people with high-risk breast cancer (HER2+ or triple-negative) for 5 years to see if early detection leads to bett…

This study is testing whether a new machine that combines radiation therapy with real-time MRI imaging is safe and practical for treating several types of cancer, including stomach and breast cancer. About 70 adults will receive this treatment along with chemotherapy. The goal is…