INVASIVE BREAST CANCER

This study is testing whether adding an immunotherapy drug (pembrolizumab) to a targeted cancer drug (sacituzumab govitecan) works better to control advanced breast cancer than the targeted drug alone. It involves about 110 adults with a specific type of breast cancer (HR+/HER2-)…

This study is testing whether adding an immunotherapy drug called cemiplimab to standard chemotherapy before surgery can help shrink tumors more effectively in patients with high-risk breast cancer. It involves 36 women with specific types of breast cancer that have not spread be…

This early-phase study is testing a personalized vaccine for people with HER2-positive breast cancer. The vaccine is made from the patient's own immune cells and is designed to teach the body's immune system to attack the cancer. Researchers are giving the vaccine alongside stand…

This study is testing whether adding a new, experimental drug called onvansertib to a standard chemotherapy (paclitaxel) is safe and effective for people with triple-negative breast cancer that has spread. The first part finds the safest dose, and the second part checks if the co…

This study is testing whether a pill called olaparib can help control metastatic breast cancer that has spread in the body. It is for patients whose cancer has a specific weakness—a mutation in certain genes that help repair damaged DNA. The goal is to see if targeting this weakn…

This study aims to see if doctors can reliably measure the amount of a common chemotherapy drug, paclitaxel, in a patient's blood. The goal is to learn if tracking these drug levels can help doctors adjust doses to better fight cancer while reducing a major side effect: nerve dam…

This study aims to grow 3D models called 'organoids' from the tumors of 50 breast cancer patients. Researchers will use these mini-tumors to collect tiny particles that cells naturally release, which can seek out cancer tissue. The goal is to learn if these particles can be used …