DELIRIUM

This study tests whether carefully managing body temperature during major cancer surgery can lower the risk of postoperative delirium (sudden confusion) and improve long-term survival in patients aged 65 and older. About 4,000 participants will be randomly assigned to either stan…

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium, cognitive decline, and disability. About 2,766 participants will be randomly assigned to one of two an…

This study tests whether giving a sleep-promoting medication (dexmedetomidine) at night can prevent delirium—sudden confusion and disorientation—in older adults after heart surgery. About 1,800 patients aged 60 and older will receive either the drug or a placebo through an IV or …

This study compares two sedatives—dexmedetomidine and midazolam—in children on breathing machines to see which one reduces delirium (a type of brain dysfunction) and improves recovery. About 372 children aged up to 11 years will take part. The goal is to find a safer sedation met…

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. Researchers will enroll 2,400 adults aged 60 and older who are having bypass or valve surgery. Participants will receive either dexm…

This study tests whether fecal microbiota transplantation (FMT) can help treat delirium in intensive care unit (ICU) patients. Delirium is a serious confusion that affects up to 80% of ICU patients and can lead to long-term brain problems. The trial will give 60 adults with delir…

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during a hospital stay. One program uses hospital staff, while the other also involves family members or care partners. The goal is to see which approach works better to reduce confus…

This early-stage study is testing whether a specific type of nerve block (TLIP block) can help older adults (65+) recover better after spinal fusion surgery. The blocks are given before surgery to reduce pain, opioid use, and confusion (delirium) after the operation. The main goa…

This study looks at whether combining two sedatives—dexmedetomidine and esketamine—can reduce delirium (sudden confusion) in older patients recovering in the ICU after surgery. Delirium is common and can lead to worse outcomes. The trial will involve 100 adults aged 60 and older …

This study looks at whether giving a small amount of the sedative midazolam during surgery can help prevent confusion (delirium) and anxiety in older patients. About 612 people aged 65 to 85 having non-heart, non-brain surgery will be randomly assigned to receive either midazolam…

This study tests if listening to music can prevent delirium in adults aged 65 and older in the intensive care unit. Participants will listen to music through headphones twice daily for a week. Researchers will compare personalized music, relaxing music, and standard care to see w…

This study tests whether melatonin, a natural sleep hormone, can help treat delirium (sudden confusion) in intensive care unit patients. Researchers want to see if it's possible to run a larger trial and if melatonin can shorten the time patients spend in a confused state. The st…

This study tests whether certain medications (haloperidol, chlorpromazine, valproic acid, or placebo) can help calm agitation in hospitalized cancer patients with delirium. The goal is to reduce distress and suffering. About 42 adults with advanced cancer and hyperactive or mixed…

This pilot study tests whether a digital therapy called VoiceLove is practical and safe for managing delirium in surgical ICU patients. Fifteen adults who had major surgery and are at risk for delirium will try two 25-minute sessions of VoiceLove per day for three days. The main …

This study looks at whether adding tablet-based brain games to standard care (like better sleep and mobility) can help older adults with delirium recover more quickly. Researchers will compare two groups of 60 patients aged 60+ in a subacute care unit. They will also explore how …

This early study tests a non-invasive device that sends gentle pulses to a nerve in the ear, aiming to safely reduce delirium (sudden confusion) in ICU patients. Ten adults with delirium will receive 30-minute sessions twice daily for up to 7 days, alongside usual care. Researche…

This study tests whether a virtual reality family support system can lower the risk of delirium (sudden confusion) in ICU patients who need a breathing tube. About 102 adults will use the VR system until their breathing tube is removed. Researchers will track delirium, medication…

This study tests whether fluvoxamine, a drug typically used for depression, can reduce the risk of delirium (sudden confusion) in older adults after non-cardiac surgery. Researchers will enroll 46 people to see if the approach is feasible and safe. If successful, it could lead to…

This study tests whether using a virtual reality program can reduce discomfort for patients recovering in the intensive care unit after major heart, lung, or abdominal surgery. About 194 adults will be randomly assigned to either receive standard care or use the VR headset twice …

This study is testing a new music therapy program to help prevent delirium (sudden confusion) in hospitalized people with brain diseases like Alzheimer's or Parkinson's. About 30 participants will receive up to five personalized music sessions, including live music or playing ins…

This study looks at why some people become confused after heart surgery. Researchers will monitor brain waves (EEG) in 200 adults before, during, and after surgery to find patterns that might predict delirium. The goal is to better understand and potentially prevent this common c…

This study follows 189 adults who experienced delirium in the ICU to understand how it impacts their physical, thinking, and emotional health after moving to a regular hospital ward. Researchers will use questionnaires to track recovery until the patient goes home. The goal is to…

This study looks at how brain activity before major surgery might affect the risk of delirium (sudden confusion) afterward. Researchers will monitor about 468 older adults using EEG and blood tests. The goal is to find early warning signs and better understand what causes postope…

This study looks at whether having nurses screen older hospital patients for delirium (sudden confusion) every day can improve patient outcomes. About 1,050 adults aged 70 and older on general medicine units will take part. Researchers will track how accurate the screening is and…

This study looks at whether a special recovery plan can help older adults (65+) who had confusion after emergency surgery. About 528 people will be followed for 18 months to see if their thinking, physical abilities, and mood improve. The goal is to find better ways to support re…

This study tests if a wearable headband that uses sound waves and light can safely monitor blood flow in the brains of people who have had a stroke, as well as those with dementia, depression, or delirium. Researchers will also use artificial intelligence to analyze the data. Abo…

This study looks at why some children become confused and agitated after waking up from anesthesia, a condition called emergence delirium. Researchers will monitor the brain waves of 400 children under 16 having planned surgery to see if patterns in brain activity can predict thi…

This study is for people over 70 who have had hip fracture surgery and will stay in the hospital for at least 5 nights. Researchers want to see if low oxygen levels during sleep are linked to delirium (sudden confusion) and other problems like infections or heart issues. The goal…

This study tests whether a camera and computer program can measure how severe delirium is in ICU patients over age 50. Researchers will compare the camera's readings with standard tests done by staff. The goal is to create a tool that is easier and more accurate for tracking deli…

This study tests a new rule that lets patients drink clear liquids (like water or apple juice) right up until they are called to the operating room. The goal is to reduce long fasting times and see if this improves comfort, nausea, and recovery. About 1,000 adults having planned …

This study tests a new brain activity monitor in 100 ICU patients who are on breathing machines and sedatives. The monitor uses a simple forehead patch to track brain signals and see if it matches standard checks for sedation and delirium. The goal is to find a better way to moni…

This study aims to find blood markers that could help predict delirium (sudden confusion) after heart surgery. Researchers will measure certain proteins and other substances in the blood of 113 heart surgery patients. The goal is to make it easier to identify patients at risk and…

This study looks at whether giving ICU staff real-time feedback and having a dedicated nurse facilitator can increase the use of a set of proven practices (the ABCDEF bundle) for adults on breathing machines. About 8,100 patients across multiple ICUs will take part. The goal is t…

This study tests whether a special program can reduce confusion (delirium) after surgery in older adults. Researchers will screen patients aged 60 and older before their operation to find those at highest risk. Those identified will receive extra care recommendations and educatio…