CRITICAL ILLNESS

This study tests whether a standard set of emergency steps—like quick blood tests, fluids, and antibiotics—can improve survival for adults with sepsis or septic shock. Researchers will compare results from 74 patients treated before the new protocol to 46 patients treated after i…

This study tests a combination of high-protein supplements, mobility-based physical therapy, and neuromuscular electric stimulation in older adults (60+) who have been in the ICU for at least two weeks and now have muscle weakness. The goal is to see if this approach can improve …

This study tests whether giving sodium bicarbonate (baking soda) to critically ill patients with metabolic acidosis and acute kidney injury can reduce serious kidney problems, including death or need for dialysis, within 90 days. About 660 adults in intensive care will receive ei…

This study tests whether adding an experimental drug (NAI) to standard care can help critically ill sepsis patients with persistently low lymphocyte counts (a sign of immune weakness) survive longer. About 50 adults in the ICU will be randomly assigned to receive either NAI injec…

This study looks at whether giving extra human albumin—a natural protein in blood—along with usual treatments can help people with surgical septic shock survive longer. Septic shock is a life-threatening condition from severe infection that often requires surgery. The trial will …

This study looks at two ways of feeding critically ill patients who are recovering from shock in the ICU: feeding through a tube into the stomach (enteral nutrition) versus feeding through a vein (parenteral nutrition). About 1,150 adults will be randomly assigned to one method. …

This study tests a computer program that gives real-time feedback to doctors and nurses to help them set ventilators in a way that protects the lungs of critically ill patients. The goal is to see if this approach helps more patients receive lung-protective ventilation, which can…

This study looks at whether giving older trauma patients extra protein drinks helps them regain muscle and strength faster than standard hospital nutrition. Sixty adults aged 45 and older will be randomly assigned to receive either extra protein supplements or usual care. Researc…

This study tests whether a daily capsule of pasteurized Akkermansia muciniphila (a food supplement) can safely help adults recover after being in the ICU for sepsis. Fifty participants will take either the supplement or a placebo for 56 days. Researchers will check for side effec…

This study tests a new approach to prevent ventilator-associated pneumonia (VAP), a common and serious lung infection in ICU patients on breathing machines. Researchers will use a rapid test (about 4 hours) to identify harmful bacteria in the airway, then give a targeted inhaled …

This study tests whether adding low-dose ketamine to standard sedation helps critically ill adults on breathing machines recover faster. About 640 participants will receive either ketamine or a placebo alongside usual care. The main goal is to see if they spend more days alive an…

This study tests whether a virtual reality (VR) program can help adults who have been in the intensive care unit (ICU) feel less stressed and in pain after being moved to a regular hospital ward. The VR sessions aim to provide psychological support and relaxation. Researchers wil…

This study tests whether a special ketone drink is safe and practical for ICU patients experiencing delirium—a state of sudden confusion and trouble thinking clearly. About 40 adults in the ICU will receive either the ketone drink or a placebo. Researchers will check if the drink…

This study compares two sedative drugs, remimazolam and midazolam, to see which one causes less confusion (delirium) after heart valve surgery in people aged 65 and older. Delirium is a common and serious problem after heart surgery, leading to longer hospital stays and memory is…

This study tests whether using a special brain wave monitor (BIS) to guide sedation can reduce the amount of sedative medicine given to adults in the ICU after heart surgery. About 144 participants will be randomly assigned to either BIS-guided sedation or standard sedation. The …

This study tests a new rehab program for adults with severe burns who are on breathing machines. The program uses special sedation, brain stimulation, and virtual reality to try to prevent muscle loss. 30 patients will be split into two groups: one gets standard care, the other g…

This study tests whether a sleep medication called lemborexant can help older adults (65+) in the intensive care unit sleep better and reduce their risk of delirium, a common and serious confusion. One hundred patients will receive either the drug or a placebo for three nights. T…

This study looks at whether ultrasound can help predict dangerous drops in blood pressure that sometimes happen when ICU patients start a type of dialysis called CVVHDF. Researchers will use heart and lung ultrasound before dialysis to see if they can spot who is at risk. The goa…

This study looks at 130 adults with sepsis to see if a kidney ultrasound (renal resistance index) and a urine test can predict acute kidney injury before it happens. Researchers will measure these markers right after sepsis diagnosis and track who develops kidney problems. The go…

This study looks at whether adding a measure of gut function to a standard organ failure score can better predict which critically ill patients are at highest risk of dying. Researchers will follow 800 adults in Turkish ICUs, using only routine data—no extra tests or treatments. …

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) is accurate for patients in intensive care who cannot tell doctors they are struggling to breathe. Researchers will compare the scale's scores with carbon dioxide levels measured by a brea…

This study will follow 4,000 people who become critically ill after a stem cell transplant (hematopoietic cell transplantation). Researchers will collect information on their health, treatments, and outcomes while in the intensive care unit (ICU). The goal is to better understand…

This study interviews 30 specialist doctors in Swedish intensive care units to understand how they decide whether to withhold or stop life-sustaining treatment for critically ill children. The goal is to learn about the ethical challenges and personal factors that influence these…

This study looks at 48 critically ill adults on breathing machines who may need fluids. Researchers will compare two methods—pulse pressure variation and a heart ultrasound technique—to see which better predicts if a patient will benefit from more fluids. The goal is to help doct…

This study looks at how sepsis changes the RNA in immune cells over time. Researchers will follow 200 sepsis patients, 50 other critically ill patients, and 40 healthy controls to map these changes. No treatments are tested; the goal is to better understand why immune problems pe…

This study will look at the medical records of 1,000 surgery patients who were admitted to the intensive care unit (ICU) in Villavicencio, Colombia, between 2022 and 2024. The goal is to find out which patients are more likely to die or have longer stays in the ICU. By understand…

This study looks at 540 high-risk heart surgery patients to find metabolic markers that can predict acute kidney injury (AKI). Researchers will use advanced techniques to track changes in the body's chemistry before and after surgery. The goal is to create a warning system that h…

This study will collect information from up to 100,000 critically ill patients in intensive care units (ICUs) around the world who receive continuous kidney dialysis (CRRT). The goal is to understand how different hospitals use this treatment and how it affects patient outcomes. …

This study will observe 1,200 adults admitted to hospital resuscitation rooms in France. Researchers want to see if patients who go directly to the resuscitation room are less likely to need intensive care within 24 hours compared to those who are admitted later from the emergenc…

This study looks at 80 adults in the ICU after major abdominal surgery who need tube feeding. Half will get diluted formula and half undiluted. The goal is to see which approach causes fewer problems like vomiting or diarrhea, helping doctors improve nutrition care.

This study brings together 30 healthcare experts from around the world to agree on the best ways to use a machine that helps ICU patients cough and clear their lungs. The goal is to create clear, safe guidelines because current practices vary widely. No patients are treated in th…

This study looks at whether giving critically ill patients on breathing machines a lower amount of protein (0.6-0.8 g/kg per day) helps them feel better and have a higher quality of life after leaving the hospital, compared to the standard protein amount (1.3 g/kg per day). About…

This study will observe 85 critically ill adults in the ICU to see if acute kidney injury (AKI) makes it harder to successfully remove a breathing tube. Researchers will track how often weaning succeeds, how long it takes, and any complications. The goal is to understand if AKI i…

This study is for people aged 65 and older who have survived a critical illness and are ready to leave the hospital. It tests whether giving patients and their family doctors personalized information helps them make better decisions about follow-up care. The goal is to improve re…

This study looks at whether giving tube feeding for 18 or 20 hours a day (with a break) is better than the standard 24-hour continuous feeding for critically ill patients in the ICU. Researchers want to see if these shorter feeding cycles can reduce time spent in the ICU, lower i…

This study looks at special molecules called SPMs that help the body turn off inflammation naturally. Researchers will measure SPM levels in blood samples from 300 ICU patients with severe infection or sepsis. No new treatments are given—only standard care. The goal is to see if …

This study checks if a special camera that looks at tiny blood vessels under the tongue can give consistent results. It will include 200 people: healthy volunteers and critically ill patients in the ICU. Researchers will take multiple measurements to see if the method is reliable…

This study follows 40 adults with serious burns to collect blood, tissue, and medical data. Researchers will look for patterns that could help predict sepsis and other complications. The goal is to build computer models that improve burn care and outcomes.

This study follows 80 adults with serious burns to collect blood, tissue, and medical record information. Researchers will look for patterns that could help predict who is at higher risk for infections like sepsis or other complications. The goal is to use this data to build comp…

This study will test whether an artificial intelligence (AI) tool, similar to ChatGPT-5, can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults will be randomly assigned to either standard care or care where doctors …

This study tracks prealbumin, a protein in the blood, in 500 critically ill adults in the ICU. Researchers want to see if changes in prealbumin levels over time are linked to patient outcomes like death or infections. The goal is to find a simple way to monitor if nutritional sup…

This study looks at how a blood thinner called enoxaparin works in critically ill patients with kidney failure, some of whom are on a blood-filtering machine. Researchers will measure drug levels in 60 ICU adults to see if standard doses are enough. The goal is to find the right …

This study will use ultrasound to measure how well the diaphragm moves in 35 critically ill patients. The goal is to compare different ultrasound methods to see which one gives the most consistent results, especially for the left side of the diaphragm. The findings may help docto…

This study looks at whether measuring changes in exhaled carbon dioxide during a leg-raising maneuver can help predict if a critically ill patient on a breathing machine needs more fluids. Researchers will observe 68 adults in the intensive care unit and compare this simple, non-…

This study looks at a new way to assess pain in intensive care unit (ICU) patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to better measure pain and adjust painkillers. The goal is to see if this approach reduc…