CRITICAL ILLNESS

This study tests whether a proactive fluid management plan helps critically ill patients with acute kidney injury who are on dialysis. The plan aims to keep fluid levels balanced by preventing and treating fluid buildup. About 150 adults in the ICU will be randomly assigned to ei…

This study compares three ways emergency responders help critically ill children breathe: a bag-mask, a tube in the throat, or a device placed above the voice box. The goal is to see which method leads to more days alive and out of the ICU within 30 days. The trial involves 3,000…

This study tests a program called PICU Up! that helps critically ill children in the intensive care unit start moving earlier. The program combines sleep support, delirium prevention, and less sedation to encourage safe mobility. Researchers will see if this approach reduces time…

This study tests a special comfort care package for 88 intensive care unit (ICU) patients to see if it improves their comfort and vital signs. Half will get routine care, the other half will get extra comfort measures like better positioning and soothing interactions. The goal is…

This study tests a virtual reality program designed for ICU patients to help with thinking skills and emotional support. About 93 adults in the ICU will use the program alongside standard care. Researchers will check if it improves comfort during the ICU stay and thinking and men…

This study looks at whether having a resuscitation order other than 'full code' is linked to a higher risk of death in ICU patients. Researchers will analyze data from 1500 critically ill adults, considering factors like age, sex, and frailty. The goal is to understand if the inc…

This study looks at 100 people who spent at least 7 days in the ICU and had kidney injury. Researchers will measure kidney function, muscle loss, and bone health using special tests. The goal is to better understand long-term effects, not to test a new treatment.

This study tracks changes in the gut bacteria (microbiome) of 500 critically ill adults admitted to the intensive care unit. Researchers want to see if these changes are linked to how long patients stay in the hospital and their risk of death up to one year later. The goal is to …

This study looks at why some ICU survivors develop dementia years later. Researchers will follow 567 new ICU patients and check their brain health using scans and spinal fluid samples. Participants can also donate their brains after death to help scientists understand the link be…

This study tests a program called PIC-TRFS to help patients aged 50 and older recover at home after a stay in the intensive care unit (ICU). The program includes health management, rehabilitation, social support, and care coordination through telehealth visits. Researchers want t…

This study looks at whether the type of breathing machine setting used in the ICU affects how well patients recover. Researchers will switch the ventilator mode used in entire ICUs every two months and track survival and time off the machine. About 4,785 adults on breathing machi…

This study aims to create and validate an Italian version of the ICU Mobility Scale, a tool that measures how well patients in intensive care can move. Researchers will enroll 100 adults in Italian ICUs to test if the scale is reliable and accurate. The goal is to help doctors an…

This study collected information on 7,500 adults admitted to Swedish ICUs with COVID-19 during the first two years of the pandemic. Researchers looked at patient characteristics, treatments, and survival rates at 30 days and one year. The goal is to understand the disease's impac…

This study looks at how much older adults move while in the intensive care unit (ICU) for a critical illness like sepsis or respiratory failure. Researchers want to see if more activity during the hospital stay leads to fewer disabilities and better physical and mental function 3…

This study follows 755 children who were in the pediatric intensive care unit (PICU) for the first time. Researchers want to learn how kids recover physically, mentally, and emotionally after a serious illness. The goal is to find ways to better support children and their familie…

This study tests a new digital platform that helps hospitals share patient information more reliably when a patient is transferred from one hospital to another. About 1,000 adults being moved to Brigham and Women's Hospital from three other hospitals will take part. The goal is t…

This study looks at 100 intensive care patients over age 65 to see if their nutritional status is linked to frailty before they were hospitalized. Researchers will use simple blood tests and frailty scores to find connections. The goal is to help doctors create more personalized …

This study surveys 100 pediatric intensive care doctors in Sweden to understand their attitudes about decisions to withdraw or withhold life-sustaining treatments in critically ill children. The goal is to gather insights, not to test a new treatment. No direct benefit to partici…

This study follows 500 adults who were in the ICU with breathing failure. Researchers want to see if COVID-19 patients have different long-term mental and physical problems compared to those without COVID-19. The goal is to understand these differences so doctors can better treat…

This study looks at how giving extra amino acids affects protein balance in critically ill patients who are on breathing machines. Researchers will measure protein breakdown and building in the body using special tracers. The goal is to learn more about metabolism, not to provide…

This study looks at whether doing computer-based brain exercises in the morning or late afternoon helps older adults (60+) recover thinking skills after an ICU stay. Many ICU survivors have trouble with memory and attention, plus disrupted sleep cycles. The goal is to see which t…

This study looks at whether giving nutrition through a feeding tube for only 12 hours a day is safe and works well for critically ill adults in the ICU. Researchers will compare this approach to the standard 24-hour feeding method. The goal is to see if the shorter schedule affec…

This study looks at two different exercise programs for people in the intensive care unit (ICU). One group uses a special bed bicycle for 30 minutes a day, while the other group also gets electrical stimulation to their leg muscles. The goal is to see which approach helps patient…

This study looks at 80 critically ill patients aged 65 and older to see if measuring thigh muscle thickness with a bedside ultrasound can help identify frailty and malnutrition. Researchers will take ultrasound measurements and assess frailty using a standard scale within the fir…

This study looks at how a serious injury or burn that requires ICU care can affect thinking and memory years later. Researchers are following 432 adults to measure long-term cognitive problems and understand how inflammation in the body might play a role. The goal is to learn why…

This study looks at how many adults in the intensive care unit (ICU) who need a breathing machine for more than 48 hours have muscle loss (sarcopenia). Researchers will use simple tests like questionnaires, body composition scans, and ultrasound to measure muscle. They will also …

This study looks at how much energy critically ill patients on breathing machines use during routine bed exercises. By measuring oxygen consumption with a special device in the ventilator, researchers hope to understand the physical demands of these exercises. The goal is to make…