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ICU protein puzzle: less may be more for Long-Term recovery

NCT ID NCT07529522

Knowledge-focused Sponsor: Ziekenhuis Oost-Limburg Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 2 times

Summary

This study looks at whether giving critically ill patients on breathing machines less protein (0.6-0.8 g/kg per day) during their early ICU stay leads to a better quality of life after leaving the hospital, compared to the standard amount (1.3 g/kg per day). About 1,026 adults will take part across multiple hospitals. The goal is to see if lower protein intake helps patients feel better and recover more fully over the following months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,026 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult (≥ 18 years-old) patient * Admission to the ICU * Invasive, mechanical ventilation initiated within 72 hours following ICU admission, or mechanically ventilated upon arrival to the ICU * Expected ICU stay on mechanical ventilation of ≥ 3 days after randomisation Exclusion Criteria: * Expected contra-indication for enteral nutrition for at least one week, at the discretion of the treating physician, such as a bowel discontinuity that cannot be solved within one week * Moribund (expected to die within 48 hours) or withholding of treatment (DNR code 3) * Previous inclusion in the PRECISe-2 trial * Transfer from another ICU with an ICU stay longer than 3 days

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Conditions

The condition(s) this trial relates to.

Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Intensive care (ICU)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    15 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AZ Delta

    Roeselare, Belgium

  • AZ Groeninge

    Kortrijk, Belgium

  • AZ Maria Middelares

    Ghent, Belgium

  • CHC MontLégia

    Liège, Belgium

  • CHR de la Citadelle

    Liège, Belgium

  • CHU Liège

    Liège, Belgium

  • Clinique St. Pierre

    Ottignies-Louvain-la-Neuve, Belgium

  • Jessa Ziekenhuis

    Hasselt, Belgium

  • MUMC+

    Maastricht, Netherlands

  • UZ Antwerpen

    Antwerp, Belgium

  • UZ Brussel

    Jette, Belgium

  • UZ Gent

    Ghent, Belgium

  • UZ Leuven

    Leuven, Belgium

  • UZ Leuven

    Leuven, Belgium

  • Ziekenhuis Oost-Limburg

    Genk, Belgium

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