COVID19

This early-stage study tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The goal was to check the vaccine's safety and see how well it triggers an immune response. Researchers gave two doses, with or without an immune booster (adjuvant…

This study tested two ways to help more people get the COVID-19 vaccine: sending text reminders, and offering extra help from a patient navigator to address barriers like transportation or scheduling. Over 65,000 adults from Utah community health centers took part. The goal was t…

This study tested two drugs, ruxolitinib and fostamatinib, in hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the pneumonia from becoming severe, requiring intensive breathing support or causing death. Participants re…

This study tested a treatment called therapeutic plasma exchange (TPE) for people with severe COVID-19. TPE filters the blood to remove harmful inflammatory substances that can cause breathing failure. The study compared standard intensive care alone to standard care plus TPE in …

This study tested whether certain drugs could safely help hospitalized COVID-19 patients who have severe breathing problems. About 473 participants received either a study drug (like aviptadil or remdesivir) plus standard care, or a placebo plus standard care. The goal was to see…

This study tested whether the drug aviptadil helps hospitalized COVID-19 patients with severe breathing problems recover better than standard care alone. About 471 adults took part, receiving either aviptadil plus usual care or a placebo plus usual care. The main goal was to see …

This study looked at whether giving inhaled heparin to COVID-19 patients on breathing machines could help them recover faster and survive. Researchers combined data from several smaller trials in Australia, Ireland, the US, and the UK. A total of 57 adults in intensive care took …

This study tested whether the drug remdesivir helps hospitalized COVID-19 patients with severe breathing failure recover better than standard care alone. 87 adults were randomly assigned to receive either remdesivir or a placebo, plus usual treatments. The main goal was to see ho…

This early study tested whether common mouthwashes can reduce the amount of SARS-CoV-2 virus that people breathe out. 34 adults with confirmed COVID-19 provided breath samples using a face mask before and after rinsing with mouthwash or water. Researchers measured viral levels to…

This study tested a new way of using breathing machines for COVID-19 patients with severe lung injury. The goal was to see if using very small breaths (ultraprotective ventilation) could reduce lung damage and improve survival compared to standard care. About 220 adults on ventil…

This study looked at different treatments to help the immune system fight COVID-19. It included 150 patients with mild to moderate symptoms. Researchers measured recovery time, fever, lung inflammation, and other health markers to see which treatments worked best.

This study tested a herbal supplement called AntiCov-220 in 82 people with health problems like HIV, hepatitis, or cancer to see if it could prevent or treat COVID-19. The supplement contains plant extracts and vitamins designed to boost the immune system and fight the virus. The…

This study looked at whether giving hospitalized COVID-19 patients two doses of plasma from people who had recovered from COVID-19, on top of standard care, helps them recover faster. 55 adults with pneumonia or low oxygen levels took part. The main goal was to see if this treatm…

This study tested whether using box fans with special filters and improving home ventilation could reduce the spread of COVID-19 among people living together. Researchers followed 214 household members after one person tested positive. They measured how many others got sick withi…

This study tested whether screening people for COVID-19 just before a large indoor concert could prevent the virus from spreading. Over 6,600 healthy adults either attended the concert after a negative test or stayed home. The goal was to see if the concert group had the same low…

This study tested whether adding functional electrical stimulation (FES) to stationary cycling helps people who survived severe COVID-19 regain physical function faster. Twenty-two adults who had been on ventilators in the ICU took part. Researchers measured how much time patient…

This study tested whether motion-controlled video game-based virtual reality exercises can reduce pain, fatigue, and improve mood and quality of life in people with long COVID. 79 adults with persistent symptoms for at least 8 weeks after a positive COVID test participated. The a…

This study tested a 6-week program called Heart Up! that uses text messages and support from nurses and loved ones to help adults with heart disease become more physically active and feel less hopeless. About 224 patients who had a heart attack or related procedure took part. The…

This study tested whether a 30-week walking program is safe for cancer patients who were hospitalized for COVID-19. Only 3 people took part, and the goal was to see if the exercise caused any serious side effects. The walking plan was adjusted to each person's fitness level.

This large study tested whether common medications already used for other conditions could help reduce mild to moderate COVID-19 symptoms in adults aged 30 and older. Over 10,000 participants took either a study drug or a placebo and reported their symptoms remotely. The goal was…

This study tested three remotely delivered programs to help 113 adults with depression, anxiety, and substance use related to COVID-19 stress. Participants either received an 8-week mindfulness course, online cognitive behavioral therapy, or standard remote monitoring and coachin…

This study tested whether common medications already approved for other uses could help people with mild to moderate COVID-19 recover more quickly. Over 3,200 adults aged 30 and older with a positive COVID-19 test and at least two symptoms took either a study drug or a placebo. T…

This study tested a 21-herb formula called modified Qing Fei Pai Du Tang (mQFPD) in 60 adults with mild-to-moderate COVID-19 who were recovering at home. The main goal was to see if the herbal treatment was safe and feasible compared to a placebo. Researchers measured changes in …

This study examined how the COVID-19 pandemic affected online gambling behaviors in France and Sweden. Researchers analyzed data from 120,000 registered gamblers to see if lockdowns and stress led to more gambling. The goal was to understand changes in gambling habits and identif…

This study looked at how a mix of home and in-clinic circuit exercises affects muscle loss and fatigue in 72 adults aged 30-85 with COPD, sleep apnea, or lingering COVID-19 symptoms. Participants completed 18 exercise sessions, 12 in person. The goal was to understand the body's …

This study looked at two ways to increase COVID-19 testing among patients at community health centers in Utah. Over 44,000 adults took part. One group got text messages reminding them to get tested. The other group got texts plus a personal navigator to help with logistics. The g…

This study looked at how the thymus gland, which produces immune cells called T cells, affects COVID-19 severity. Researchers examined 85 hospitalized patients to see if genetic differences in thymus function are linked to worse lung damage. The goal was to better understand why …

This study followed 6,000 adults who had COVID-19 symptoms to understand long-term health problems like chronic fatigue, heart issues, and brain fog. Participants completed online surveys every 3 months for 18 months. The goal was to learn how the virus affects people over time, …

This study tracked 219 adults with severe COVID-19 who needed a ventilator to breathe. Researchers wanted to see how many also developed serious fungal infections, especially from a mold called Aspergillus. They used standard tests to check for these infections, but did not give …

This completed study looked at 543 people who survived severe COVID-19 lung failure (ARDS) to see if their social and economic background affected their recovery. Researchers measured lung function, mental health, and quality of life six months after leaving the ICU. The goal is …

This completed Phase 2 trial tested the safety and effectiveness of different drug combinations in people with COVID-19. It used a master protocol that allowed both hospitalized and non-hospitalized patients to join. Only 4 participants were enrolled, and the study focused on mea…

This study followed 187 people who had COVID-19 to measure their antibody levels over 24 months. Researchers wanted to see how long antibodies stay in the body and whether they continue to work against the virus. They also looked at how the severity of the initial infection and v…

This study looked at eye problems in 23 COVID-19 patients in the intensive care unit. Researchers checked for damage to the cornea, retina, and optic nerve over time. The goal was to find and treat eye issues early to prevent permanent vision loss.

This study followed 105 pregnant women diagnosed with COVID-19 to learn how the infection affects mothers and their newborns. Researchers measured antibodies in the mothers' blood and breastmilk, and in the babies' cord blood, up to 6 weeks after birth. The goal was to better und…

This study looked at how working in intensive care units during the COVID-19 outbreak affected the mental health of doctors, nurses, and other caregivers. Over 700 staff members completed surveys about post-traumatic stress disorder (PTSD), anxiety, depression, and burnout. The g…

This study looked at how many people with cystic fibrosis (CF) have antibodies against the COVID-19 virus. Researchers followed 152 adults and children with CF for two years, testing their blood for antibodies and checking their health. The goal was to learn if CF patients are le…

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder (PTSD), depression, and burnout using standard questionnaires. The goal was to understand how c…

This study followed 85 adults who survived severe COVID-19 and needed a breathing machine in the ICU. Researchers tracked their recovery of walking, thinking, and daily activities from the hospital until they returned home. They compared these patients to healthy volunteers to un…

This study followed over 1,000 people in the Dominican Republic to learn how COVID-19 spreads and how to control it. Researchers tracked symptoms, tested blood for antibodies, and asked about handwashing habits. The goal was to understand the virus better and find ways to reduce …

This study looked at how the COVID-19 mRNA vaccine (Comirnaty) works in people with weakened immune systems, such as those with HIV, organ transplants, or certain blood cancers, compared to healthy individuals. About 539 adults received two vaccine doses, and researchers measured…

This completed study looked at why lying face down (prone positioning) helps some patients with severe lung failure (ARDS), including those with COVID-19. Researchers used lung ultrasound to measure lung health in 60 adults on breathing machines. The goal was to understand differ…

This study tracked over 11,000 COVID-19 patients to find out how often they develop dangerous blood clots in arteries or veins. Researchers looked at risk factors, treatments, and outcomes like heart attack, stroke, or death. The goal was to better understand and prevent these co…

This study looked at how a COVID-19 infection during pregnancy, along with related stress, might affect a baby's brain development. Researchers followed 62 mothers and their infants, using surveys and brain scans to measure stress, mental health, and early learning skills. The go…

This study followed 1,366 people in Luxembourg who tested positive for COVID-19. Researchers tracked their symptoms and health for up to a year to understand why some get very sick while others have mild illness. The goal was to find factors that predict severe disease, not to te…

This study used advanced total-body PET scans to compare lung function in 13 COVID-19 patients and healthy volunteers. Researchers measured how well the lungs' blood-air barrier worked, and checked for changes 4 months later. The goal was to learn more about how COVID-19 affects …

This study examined over 12,000 nursing home residents to see how well COVID-19 prevention measures (like restricting visitors and isolating sick residents) worked. Researchers wanted to know if these measures reduced deaths from COVID-19 but also if they might have increased dea…

This study looked at how the first wave of COVID-19 (April–June 2020) changed the way people with multiple sclerosis reported relapses and how doctors managed them, compared to the same months in 2019. Researchers reviewed records from 51 patients across 5 UK hospitals to see if …

This study tested whether a breath analysis test could help diagnose or predict the course of liver diseases, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants to detect unique chemical patterns. The goal was to develop a non-invasive diagnosti…

This study looked at why some people who were hospitalized for COVID-19 still feel tired and out of breath. Researchers measured breathing muscle strength in 50 survivors—half had been on a ventilator, half had only needed extra oxygen. The goal was to understand how severe COVID…

This study looked at whether testing children hospitalized with severe pneumonia for tuberculosis (TB) right away, using a rapid test called Xpert Ultra on stool and nose samples, could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB-burden countries took pa…

This study measured COVID-19 antibodies in over 2,800 primary care health workers (like doctors, dentists, and pharmacists) and their household members in France. The goal was to understand how many had been exposed to the virus and how their immune systems responded. Researchers…

This study looked at whether weakness in the diaphragm, the main breathing muscle, causes ongoing shortness of breath and fatigue in people who had COVID-19 but were not hospitalized. Researchers measured breathing muscle strength and used ultrasound in 25 adults. The goal was to…

This study looked at eye damage in 34 people who were hospitalized for severe COVID-19. Researchers used advanced eye imaging to find problems caused by the virus, inflammation, or treatments like oxygen and medications. The goal was to better understand and describe these eye is…

This study followed 211 older adults who were hospitalized with COVID-19 to see how their ability to move, think, and do daily tasks changed over time. Researchers measured recovery using standard tests of mobility and cognition. The goal is to understand the long-term effects of…

This study looked at how well the body's immune system remembers COVID-19 after infection. Researchers measured antibodies in 829 adults who had tested positive for COVID-19, following them for up to 12 months. The goal was to understand how long immunity might last and to test t…

This study looked at 57 adults with mild or no COVID-19 symptoms to understand how their immune system responds to the virus. Researchers measured immune markers and how quickly the virus cleared from the body. The goal was to learn why some people fight off the infection easily,…

This study looked at how to best encourage regular COVID-19 testing for children with intellectual and developmental disabilities (IDD) and their teachers. Over 1,100 participants from two special school districts took part. The goal was to find the most effective messages and st…

This study followed 200 adults who had COVID-19 to see how the disease affects their heart and mental health over time. Participants wore health trackers to monitor heart problems like irregular beats and heart failure, and completed surveys about anxiety, depression, and substan…

This study collected blood, urine, and kidney tissue samples from 90 hospitalized COVID-19 patients who also had acute kidney injury. Researchers aimed to better understand how COVID-19 affects the kidneys and to identify potential treatments. Participants were followed up three …

This study enrolled 214 people who tested positive for COVID-19. Participants received daily text messages asking about their symptoms, such as fever, cough, and loss of taste or smell. The goal was to learn how symptoms develop and change throughout the infection, not to test an…

This study followed 355 adults in Suffolk and North Essex who had Long COVID for up to 36 months after infection. The goal was to understand their symptoms and how the condition affected daily life, so doctors can better diagnose and treat it. Researchers focused on a wide range …

This study looked at whether people with cystic fibrosis (CF) have different immune responses to COVID-19. Researchers tested blood samples from 113 CF patients in Europe over two years to check for antibodies from natural infection or vaccination. The goal was to understand how …

This study looked at whether the COVID-19 vaccine triggers a strong immune response in people with multiple myeloma or Waldenstrom's macroglobulinemia. Researchers measured antibody levels 28 days after the final vaccine dose in 146 participants. The goal was to understand vaccin…

This study looked at the best way to test for COVID-19 in K-12 schools serving underserved communities in St. Louis. Over 1,300 students and staff took part. Researchers compared two strategies: testing only people with symptoms versus weekly testing of everyone plus symptom test…

This study followed 300 adults who had mild to moderate COVID-19 and were not hospitalized. Researchers called them each month for a year to see how long symptoms lasted and how they affected daily activities. The goal was to understand lingering symptoms and when people felt ful…

This study looked at 32 adults in the ICU on ECMO (a heart-lung machine) who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole moved through their bodies to find the best dose. The …

This study looked at 332 adults who had severe COVID-19 pneumonia and needed oxygen in the hospital. Researchers used CT scans and breathing tests to check for lasting lung damage three months after discharge. The goal was to understand how often and how severe these respiratory …

This study surveyed 714 breast cancer survivors to understand their experiences with COVID-19 vaccination, focusing on lymph node swelling. Researchers wanted to know if this common vaccine side effect causes extra worry or risk of lymphedema in patients who had lymph node surger…

This study looked at how COVID-19 spread in four hospitals in Bamako, Mali. Researchers tested 450 patients and healthcare workers for the virus and checked their immunity. They also tested a fast, portable molecular test and studied virus changes over time. The goal was to bette…