CARDIOGENIC SHOCK

This study tests whether adding a balloon pump (IABP) to standard ECMO support helps the heart recover better in people with severe cardiogenic shock. About 104 adults will be randomly assigned to get ECMO alone or ECMO plus the balloon pump. Researchers will measure heart functi…

This study tests whether replacing a narrowed heart valve right away (within 12 hours) helps people with severe aortic stenosis who are in cardiogenic shock, compared to the usual approach of stabilizing them in the ICU first. Thirty participants will be randomly assigned to one …

This study tests a temporary heart pump called iVAC 2L in 100 people with severe coronary artery disease who need high-risk angioplasty. The pump helps keep blood flowing during the procedure, which may reduce the chance of death, heart attack, or stroke. The goal is to see if th…

This study tests a minimally invasive procedure to repair a leaky heart valve in people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 144 adults in intensive care will be randomly assigned to either standard medical therapy or…

This study tests whether adding an intra-aortic balloon pump (IABP) to standard VA-ECMO support helps more patients with cardiogenic shock successfully wean off ECMO within 30 days. About 430 adults will be randomly assigned to receive either ECMO alone or ECMO plus IABP. The goa…

This study looks at whether setting a personalized blood pressure goal based on a patient's vein pressure can improve survival and reduce organ damage in adults with cardiogenic shock, a severe heart condition where the heart can't pump enough blood. About 406 participants will b…

This study tests whether using a heart-lung machine (ECMO) before a high-risk aortic valve replacement can prevent death, cardiac arrest, or emergency surgery. It includes 30 adults with severe aortic stenosis who are unstable or have complex anatomy. Participants receive ECMO su…

This study looks at 408 adults with severe heart shock who need a heart-lung machine (ECMO) and have kidney injury. It compares starting kidney dialysis early versus waiting for standard timing. The goal is to see which approach reduces death or the need for long-term dialysis.

This study tests whether using a special heart monitor (pulmonary artery catheter) early in the hospital can lower the risk of death for people in cardiogenic shock caused by heart failure. About 400 adults with severe heart failure and shock will be randomly assigned to get eith…

This study tests whether a special heart monitor can help prevent serious problems like death, heart failure, or repeat hospital stays in people who have survived a severe heart condition called cardiogenic shock. About 40 adults will be randomly assigned to get the monitor or st…

This study looks at whether placing a special balloon pump (IABP) early after starting ECMO can improve survival in adults with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. About 358 participants will be randomly assigned to get the ball…

This study tests whether a personalized blood transfusion approach, based on oxygen levels, is better than the standard method for people on a heart-lung machine (ECMO) due to severe heart failure. About 236 adults will be randomly assigned to one of two strategies to see which r…

This study tests a new temporary heart pump (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The pump is inserted through a blood vessel to help the heart work and stabilize blood pressure. The goal is to…

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study tests the Cardiohelp device, a heart-lung machine for children with severe heart failure, to see if it is safe and works well for up to 30 days. It also compares two blood thinners, heparin and bivalirudin, to find which causes fewer bleeding or clotting problems. Abou…

This study tests whether giving a special life-support machine (ECMO) at the scene of a cardiac arrest helps more people survive than waiting until they reach the hospital. About 90 adults under 70 who have a witnessed heart attack and receive bystander CPR will be included. The …

This study looks at whether giving a special ketone drink through a feeding tube is safe and practical for people with severe heart failure. The goal is to see if it can help the heart use energy better. The study involves 12 participants with very weak hearts who are in the hosp…

This observational study will follow 600 adults hospitalized with acute heart failure or cardiogenic shock. Researchers will collect information from routine care, plus extra blood and urine samples, to see if they can better identify different types of shock and predict who is a…

This registry will collect health data from 8,000 adults with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers aim to track what treatments are used and how patients fare, including survival rates in the hospital and up…

This observational study follows 800 adults admitted to a cardiology department with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will review medical records from 2017 onward to see how treatments and survival rates…

This study is a large registry that will follow 3,000 people hospitalized with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect information on patient profiles, treatments, and outcomes to better understand…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals. Then, with help from patients, families, and staff, they will design…

This study looks at data from 100 adults with cardiogenic shock who received an Impella 5.5 heart pump. Researchers aim to build a tool that uses pump signals to predict whether a patient's own heart will recover. The goal is to improve decision-making and reduce complications li…

This registry follows 350 people who survived cardiogenic shock (a severe form of heart failure) after they leave the hospital. Researchers want to learn about deaths, hospital readmissions, and other challenges patients face in the months and years after discharge. The goal is t…

This study watches 600 adults on a heart-lung machine (ECMO) for severe shock to see how often they develop heart rhythm problems like atrial fibrillation. It tracks complications and recovery times. The goal is to learn more, not to test a new treatment.

This study looks back at medical records of 3,000 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers want to see if having a special shock team in place since 2017 has improved survival rates. They will also c…

This study watches 20 adults in cardiogenic shock who need a temporary heart pump (IABC). Researchers want to see if the stiffness of the arteries changes how well the pump works. They will measure blood flow and other vital signs before, during, and after the pump is used. The g…

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify different patient types. The goal is to improve future treatment and care for th…

This study is a large registry that will collect data on how the CytoSorb device is used in real-world intensive care units. It aims to track outcomes like death rates in the ICU and hospital for patients with serious conditions such as septic shock, ARDS, and liver failure. The …

This study follows 500 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect data from four specialized centers to understand what treatments work best and why some patients do better than others. No…

This study looks at how genes affect the immune system and treatment responses in people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect blood samples from 300 patients to identify genetic patterns li…