CARDIOGENIC SHOCK

This study tests a new device called SynFlow Duro, a temporary heart pump for people who go into severe shock after heart surgery. About 60 adults in China will receive the pump to see if it helps their heart recover or keeps them stable until a transplant or permanent device. Th…

This study tests if the drug istaroxime can help people with mild to moderate cardiogenic shock caused by acute heart failure. About 600 adults will receive either istaroxime or a placebo through an IV for 48 hours. Researchers will check if it improves blood pressure, breathing,…

This early-phase trial tests a new treatment for people in shock after a severe heart attack. The therapy uses specially engineered immune cells (CAR-DC) to target a protein found in heart scar tissue, aiming to calm the immune response. The study will enroll 18 patients and prim…

This study compares two drugs, norepinephrine and dopamine, to see which works better as the first treatment for adults with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. About 512 participants will be randomly assigned to receive one of …

This study tests whether using a heart pump (Impella 5.5) along with standard heart failure medications can help people with severe heart failure and shock recover without needing a heart transplant or permanent artificial heart. About 250 adults with weak hearts (ejection fracti…

This study tests whether routinely placing a small tube (catheter) in the leg can prevent serious limb complications in patients on a heart-pump machine. About 500 adults with severe heart failure or shock will be randomly assigned to get the tube placed right away or only if nee…

This study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study looks at 30 adults on a heart-lung machine (ECMO) for severe heart failure. Researchers will measure brain oxygen levels and compare them to blood flow and other vital signs. The goal is to see if brain oxygen readings can help guide treatment and predict recovery.

This study tests a new device that can measure a substance called nucleosomes in the blood right at the patient's bedside. Researchers want to see if these levels can help predict which critically ill patients are at higher risk of dying within 30 days. The study will include 130…

This study tests a new, non-invasive device called ODIN that measures how well oxygen is being used in the tiny blood vessels of patients with advanced heart failure or cardiogenic shock in the ICU. About 30 adults will have their oxygen measurements taken with the device and com…

This study will track 320 people in Hong Kong who have a heart attack complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will collect data on standard treatments, including the use of a heart pump called Impella, to…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study looks at 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems happen and compare the settings doctors used with those suggested by a computer algorithm. The goal is to improve future care…

This study looks at whether a standard way to measure pressure in the heart's left chamber (using a balloon-tipped catheter) gives the same results as the most accurate method (directly measuring pressure in the left atrium). The researchers will study 136 adults having heart sur…