CARDIAC ARREST

This study is testing a set of coordinated medical treatments, called a 'neuroprotection bundle,' to improve brain recovery in adults who survive a cardiac arrest. It will compare this bundle to usual care in over 1,000 patients. The goal is to see if carefully managing body temp…

This study is testing if a combination of three drugs (epinephrine, vasopressin, and methylprednisolone) works better than the current standard single drug (epinephrine) for treating adults who suffer a sudden cardiac arrest outside the hospital. The goal is to get the heart beat…

This study is testing whether giving high-dose vitamin C through an IV soon after a cardiac arrest can help control the dangerous shock that often follows. Researchers will compare standard care alone to standard care plus vitamin C and vitamin B1 in 234 unconscious patients who …

This study is testing if a small balloon can be placed in a major artery during a cardiac arrest to help improve blood flow to the brain and heart. It will be done by a specialized air ambulance team on 40 patients who have collapsed outside of a hospital. The goal is to see if t…

This large study is testing if changing the standard treatment order for cardiac arrest can save more lives. It will see if giving a medication called amiodarone one step earlier than current guidelines helps restore a normal heart rhythm faster. The goal is to improve survival a…

This study is testing whether new artificial intelligence software can read heart rhythm tracings as accurately as a cardiologist. The software analyzes electrocardiogram (ECG) data from over 5,000 high-risk heart patients to detect dangerous patterns and predict serious events. …

This study aims to see if using a special, focused ultrasound of the heart is safe and helpful for guiding treatment of critically ill patients in the emergency room or intensive care unit. It will enroll 1,000 adult patients who are in shock or cardiac arrest and are already sch…

This study is testing whether a personalized rehabilitation program helps survivors of sudden cardiac arrest return to work better than standard care alone. It will involve 214 adult survivors who were working before their cardiac arrest. The main goal is to see if more people ar…

This study aims to find out if using a clear plastic box over a patient's head protects healthcare workers from catching COVID-19 during CPR and other emergency procedures. Researchers will simulate cardiac arrest scenarios with 240 healthcare workers across North America to meas…

This study aims to understand the relationship between low oxygen levels and cardiac arrest in organ donors. Researchers will observe 50 donors during a specific type of donation procedure to measure oxygen levels at the moment of arrest. The goal is to see if these oxygen levels…

This study aims to compare different scoring systems that doctors use to predict brain damage in comatose patients who survive a cardiac arrest. Researchers will enroll 4,500 adults admitted to intensive care after their heart stops beating. The goal is to find the most accurate …

This study aims to understand how the quality of chest compressions during CPR and the care provided after a child's heart stops affect their survival and brain function. Researchers will observe 7,000 children across multiple hospitals who receive CPR, measuring details like com…

This study aims to find specific markers in the blood that can help doctors predict which patients with sudden cardiac arrest will benefit from a powerful, advanced life support treatment called ECPR. Researchers will analyze blood samples from about 130 patients before and after…

This study aims to improve how doctors predict brain recovery in unconscious patients who survive cardiac arrest. Researchers will collect detailed information from 600 patients using standard tests at specific times to create a better prediction model. The goal is to reduce bias…

This study aims to improve the selection of patients for a specialized, advanced form of cardiac arrest treatment called ECPR. Researchers will follow 700 patients to identify which factors predict not just survival, but also good long-term brain function and life satisfaction. T…

This study aims to understand if being frail makes it harder to survive an in-hospital cardiac arrest. Researchers will look at children who need emergency resuscitation (a 'code blue') to see if their level of frailty is linked to survival and recovery. The goal is to gather kno…

This study is testing whether a special educational video game can help intensive care unit (ICU) nurses learn a specific cooling treatment for patients who survive a cardiac arrest. The game is being compared to traditional classroom teaching. Researchers want to see if the game…

This study aims to find out which of two common methods for helping patients breathe during a hospital cardiac arrest leads to better survival and recovery. It will compare using a simpler breathing device placed in the throat first versus using the more complex traditional breat…

This study aims to measure the real-world volume of air delivered to the lungs when medical staff manually breathe for a patient during an in-hospital cardiac arrest. It will compare two standard airway devices used in these emergencies. The research involves 30 patients already …

This is a small, early-stage study to see if it's safe and practical to give magnesium sulfate to people whose hearts have been restarted after stopping. The main goal is to gather data on how to run a future, larger trial. Researchers will check if the treatment can be given qui…

This study is testing a new type of catheter that can continuously measure oxygen levels in the blood leaving the brain of comatose patients who have survived a cardiac arrest. The goal is to see if this new, real-time monitor is as accurate as the current method, which requires …