CARDIAC ARREST

This study tests whether giving high-dose vitamin C early after a cardiac arrest can help patients recover from shock. About 234 adults who remain unconscious after a cardiac arrest and need medication to keep their blood pressure up will be randomly assigned to receive either st…

This study tests whether giving the heart medication amiodarone one cycle earlier than usual during a cardiac arrest can help restore a normal heartbeat faster. About 585 adults who have a shockable heart rhythm after a cardiac arrest outside the hospital will take part. Research…

This study tests whether placing a balloon in the main artery (aorta) during CPR helps restart the heart more often than standard CPR alone. About 98 adults who have a cardiac arrest in the hospital will be randomly assigned to get either standard care or standard care plus the b…

This study compares two methods doctors use to help patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed above the voice box) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest w…

This study tests whether giving a combination of three drugs (epinephrine, vasopressin, and a steroid) to adults who suffer a sudden cardiac arrest outside the hospital can restart their heart better than the standard single drug (epinephrine). About 1,344 participants will be ra…

This study tests whether a group of treatments—including careful control of body temperature, oxygen, blood pressure, and other factors—can help people who have had a cardiac arrest recover better brain function. About 1,000 adults who are unconscious after resuscitation will be …

This study tests if a special website can help people who survived a cardiac arrest outside the hospital. The goal is to improve their quality of life, mood, thinking, and social connections. About 106 survivors will use the web app and report how they feel.

This study looks at whether a simpler form of CPR—using only chest compressions—works as well as standard CPR (compressions plus rescue breaths) for people who collapse from cardiac arrest outside a hospital. About 3,260 adults with witnessed cardiac arrest will be included, and …

This study looks at how doctors predict recovery for people who remain unconscious after a cardiac arrest. Researchers want to see if using a set of tests at specific times can give a clearer picture of a patient's chances. The goal is to help families and doctors wait longer bef…

This study looks for specific proteins, metabolites, and platelet changes in the blood of 130 cardiac arrest patients who receive emergency heart-lung support (ECPR). The goal is to find markers that can predict which patients are most likely to survive or recover brain function.…

This study compares different scoring systems to predict brain damage in adults admitted to the intensive care unit after cardiac arrest. Researchers will enroll 4,500 patients to see which score best helps doctors decide on treatments and inform families. The goal is to improve …

This study explores whether frailty—a state of increased vulnerability—affects how well patients recover after a code blue (emergency CPR). Researchers will track factors like the reason for the emergency, how long CPR lasts, and what equipment is used. The goal is to better unde…

This study tests a personalized rehabilitation program for people who survived a sudden cardiac arrest outside the hospital. The goal is to help them return to work within 12 months. 214 participants will either receive the special rehab plus usual care, or usual care alone. The …

This study looks at whether using a special heart ultrasound (called transesophageal echocardiography) during emergencies helps doctors better treat critically ill patients, including those in cardiac arrest or shock. Researchers will track 1,000 adults in the ER and ICU to see i…

This study watches how chest compressions are given to children (up to age 18) during cardiac arrest. Researchers want to see if following American Heart Association guidelines for compression depth, rate, and timing leads to better outcomes. No new treatments are tested—just car…

This study looks at whether using a balloon to block the aorta (a major blood vessel) during a heart attack outside the hospital can help blood flow to the heart and brain. It involves 40 adults who are in cardiac arrest and receiving standard emergency care. The goal is to see i…

This study tests a special catheter that continuously measures oxygen levels in blood leaving the brain of comatose patients after cardiac arrest. Current methods require drawing blood and sending it to a lab, which takes time. The new catheter provides instant readings, which co…

This study follows 700 people who had a cardiac arrest and were treated with a machine called ECMO (which helps the heart and lungs work). The goal is to find out which patients are most likely to survive with good brain function, and to improve how doctors choose who gets this t…

This study measures the actual amount of air given to patients during CPR for cardiac arrest, comparing two common breathing devices: a tracheal tube and a laryngeal mask airway. About 30 adults already in a larger trial will have a small sensor added to track air flow. The goal …

This study tests whether a digital serious game can improve critical care nurses' knowledge of targeted temperature management (TTM), a cooling treatment used after cardiac arrest. 120 ICU nurses will be split into two groups: one gets standard lectures, the other gets lectures p…

This study looks at 50 organ donors to measure how low oxygen levels drop when their heart stops during a Maastricht III procedure. The goal is to better understand what happens at the moment of cardiac arrest. No treatment is given—it is purely observational.

This study tests whether giving magnesium sulfate soon after a cardiac arrest can help protect the brain. Researchers will enroll 178 adults who regained a pulse within 2 hours. The main goal is to see if the treatment is safe and practical, not yet to prove it works. Results wil…

This study tests whether drones can deliver automated external defibrillators (AEDs) to people having a cardiac arrest in rural areas faster than emergency responders. Researchers will compare arrival times and see if drone delivery is practical. About 128 adults who suffer cardi…

This study is testing a cloud-based artificial intelligence program called Willem that reads electrocardiograms (ECGs) to detect heart rhythm problems and other abnormal patterns. Researchers will compare the AI's performance to that of board-certified cardiologists using data fr…

This study looks at whether placing a clear plastic box over a patient's head during CPR can reduce the spread of viruses, like COVID-19, to healthcare workers. Researchers will have 240 healthcare providers perform CPR on mannequins, with and without the box, to measure how well…