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Can better CPR save more kids? largest study launches

NCT ID NCT02708134

Knowledge-focused Sponsor: Children's Hospital of Philadelphia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study watches how doctors and nurses perform CPR on children who have had a cardiac arrest. Researchers will check if following American Heart Association guidelines for chest compression depth, rate, and timing leads to better outcomes. Up to 7,000 children across multiple hospitals will be included. The goal is to find out which CPR techniques work best to improve survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could identify which CPR techniques work best for children, leading to improved resuscitation guidelines.
What could go wrong
This is an observational study, so it cannot prove cause and effect. Results may not apply to all hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 7,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2016

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Data will be collected from pediatric cardiac arrest events as part of standard clinical operations.

Ages

0 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient received chest compressions for at least 1 minute * Patient between gestational age ≥37 weeks and 18 years of age Exclusion Criteria: * Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event

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Conditions

The condition(s) this trial relates to.

cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest Cardiopulmonary arrest

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    61 sites in 15 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aichi Children's Health and Medical Center

    RECRUITING

    Aichi, 474-8710, Japan

  • Akron Children's

    RECRUITING

    Akron, Ohio, 44308, United States

  • Albany Medical Center

    RECRUITING

    Albany, New York, 12208, United States

  • Alberta Children's

    RECRUITING

    Calgary, AB T3B, Canada

  • All Children's Hospital

    NOT_YET_RECRUITING

    St. Petersburg, Florida, 33701, United States

  • BC Children's

    RECRUITING

    Vancouver, British Columbia, V6H 3N1, Canada

  • Boston Children's

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • Cedars-Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

  • Children's Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

  • Children's Healthcare of Atlanta (CHOA)

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Hospital of Richmond at VCU

    RECRUITING

    Richmond, Virginia, 23219, United States

  • Chldren's Hospital of Orange County

    RECRUITING

    Orange, California, 92868, United States

  • Cincinnati Children's Hospital Medical Center

    RECRUITING

    Cincinnati, Ohio, 45229, United States

  • Cohen Children's Medical Center

    RECRUITING

    Queens, New York, 11040, United States

  • Dartmouth Hitchcock Medical Center

    RECRUITING

    Lebanon, New Hampshire, 03756, United States

  • Dell Children's Medical Center

    RECRUITING

    Austin, Texas, 78723, United States

  • Erasmus MC - Sophia Children's

    RECRUITING

    Rotterdam, 3015, Netherlands

  • Great Ormond Street Hospital

    RECRUITING

    London, WC1N 3JH, United Kingdom

  • Gregorio Marañón General University Hospital

    RECRUITING

    Madrid, 46 28007, Spain

  • IRCCS Ospedale Pediatrico Bambino Gesù

    RECRUITING

    Roma, 486686, Italy

  • Instituto Roosevelt

    RECRUITING

    Bogotá, Colombia

  • KK Women's & Children's Hospital

    RECRUITING

    Singapore, 229899, Singapore

  • Kaiser Permanente

    RECRUITING

    Los Angeles, California, 90027, United States

  • Kentucky Children's Hospital

    RECRUITING

    Lexington, Kentucky, 40536, United States

  • King Chulalongkorn University

    RECRUITING

    Bangkok, 10330, Thailand

  • Kobe Children's Hospital (Hyogo Prefectural)

    RECRUITING

    Kobe, 650-0047, Japan

  • Lurie Children's (Children's Hospital of Chicago)

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Medical City Children's Hospital

    RECRUITING

    Dallas, Texas, 75230, United States

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Medical University of South Carolina

    NOT_YET_RECRUITING

    Charleston, South Carolina, United States

  • Morgan Stanley Children's Hospital

    RECRUITING

    New York, New York, 10032, United States

  • Mount Sinai Kravis Children's Hospital

    RECRUITING

    New York, New York, 10029, United States

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 100229, Taiwan

  • National University Hospital

    RECRUITING

    Singapore, 119074, Singapore

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43205, United States

  • Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, United States

  • Nemours Children's Hospital

    RECRUITING

    Wilmington, Delaware, 19803, United States

  • Perth Children's Hospital

    RECRUITING

    Nedlands, 6009, Australia

  • Queensland Children's Hospital

    RECRUITING

    South Brisbane, 4101, Australia

  • Rady Children's Hospital

    RECRUITING

    San Diego, California, 92123, United States

  • Riley Hospital for Children

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Sabara Hospital Infantil

    RECRUITING

    São Paulo, 01227-200, Brazil

  • Seattle Children's Hospital

    RECRUITING

    Seattle, Washington, 98105, United States

  • Seoul National University Bundang Hospital

    RECRUITING

    Seongnam, 13620, South Korea

  • St. Louis Children's Hospital

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Stanford University

    RECRUITING

    Palo Alto, California, 94304, United States

  • Starship Children's Hospital

    RECRUITING

    Auckland, 1023, New Zealand

  • Stollery Children's Hospital

    RECRUITING

    Edmonton, Alberta, T6G 2B7, Canada

  • Stony Brook University Hospital

    RECRUITING

    Stony Brook, New York, 11794, United States

  • The Children's Hospital at Westmead

    RECRUITING

    Westmead, New South Wales, 2145, Australia

  • The Children's Hospital of San Antonio

    RECRUITING

    San Antonio, Texas, 78207, United States

  • The Johns Hopkins Hospital

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • Tokyo Metropolitan Children's Medical Center

    RECRUITING

    Tokyo, 183-8561, Japan

  • University of Chicago, Comer Children's Hospital

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of Iowa Stead Family Children's Hospital

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27514, United States

  • University of Texas Southwestern

    RECRUITING

    Dallas, Texas, 75390, United States

  • Upstate Golisano Children's Hospital

    RECRUITING

    Syracuse, New York, 13210, United States

  • Valley Children's Hospital

    RECRUITING

    Madera, California, 93636, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.