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Could vitamin c save lives after cardiac arrest? new trial investigates

NCT ID NCT05817851

Disease control Sponsor: Centre Hospitalier de Bethune Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether giving high-dose vitamin C and thiamine early after cardiac arrest can help patients recover from shock. About 234 adults who remain unconscious after cardiac arrest and need blood pressure support will be randomly assigned to get either standard care or standard care plus high-dose vitamin C for three days. The main goal is to see if vitamin C helps patients come off blood pressure medication faster.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-dose vitamin C (ascorbic acid) plus thiamine (vitamin B1)
What this could lead to
If it works, this could offer a simple, safe way to reduce shock and organ failure after cardiac arrest, potentially improving survival and brain recovery.
What could go wrong
This is an early phase 2 trial with 234 participants, so results are not definitive. High-dose vitamin C may not improve outcomes and could cause side effects like kidney stones.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 234 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2023

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients still comatose (Glasgow coma scale \< 8) after an OHCA of presumed cardiac origin with ROSC \< 60 min; * and treated with a norepinephrin or an epinephrin continuous infusion during at least 30 min before randomization to maintain mean arterial pressure (MAP) ≥ 65 mmHg. Exclusion Criteria: * patients still comatose (Glasgow coma scale \< 8) after an OHCA of presumed cardiac origin with ROSC \< 60 min; * and treated with a norepinephrin or an epinephrin continuous infusion ≥ 0.2µg/kg/h, within 4 hours after OHCA, during at least 30 min/h to maintain mean arterial pressure (MAP) ≥ 65 mmHg. Exclusion criteria: * minor or pregnant women; * OHCA from evident extracardiac cause (trauma, bleeding, poisoning, etc.); * interval between RACS and randomization \> 6 hours; * extracorporeal circulatory assistance requirement in the first 4 hours after OHCA; * history of urolithiasis, oxalate nephropathy or hemochromatosis; * glucose-6-phosphate deshydrogenase deficiency; nephrolithiasis, hyperoxalyurie * patients already treated with vit-C; known vit-C deficit; * inclusion in another study; * pre-existent severe chronic kidney disease (glomerular filtration rate \< 30ml/min); * treatment limitationsor moribound * Patient with derpived freedom or with legal protective measures. * Patient not covered by French national health insurance

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Conditions

The condition(s) this trial relates to.

cardiac arrest post-cardiac arrest syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    10 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CH d'Arras

    RECRUITING

    Arras, France

  • CH de Melun (GHSIF)

    ACTIVE_NOT_RECRUITING

    Melun, France

  • CH de Versailles

    NOT_YET_RECRUITING

    Versailles, France

  • CHI Nord-Ardennes

    ACTIVE_NOT_RECRUITING

    Charleville-Mézières, France

  • Centre Hospitalier Béthune

    RECRUITING

    Béthune, 62408, France

  • Centre Hospitalier Toulon La Seyne sur Mer

    RECRUITING

    Toulon, France

  • Centre Hospitalier Universitaire d'Amiens

    ACTIVE_NOT_RECRUITING

    Amiens, France

  • Centre Hospitalier Universitaire de LILLE

    RECRUITING

    Lille, France

  • Centre Hospitalier de Dieppe

    RECRUITING

    Dieppe, France

  • Centre Hospitalier de LENS

    RECRUITING

    Lens, 62307, France

  • Centre Hospitalier de Rouen

    RECRUITING

    Rouen, France

  • Centre Hospitalier de Valenciennes

    ACTIVE_NOT_RECRUITING

    Valenciennes, France

  • GHEF Site Marne La Vallée

    RECRUITING

    Jossigny, France

  • Hôpital Lariboisière

    RECRUITING

    Paris, 75475, France

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