AUTISM SPECTRUM DISORDER

This study tests whether adding umbilical cord stem cell infusions to standard glutathione therapy can improve autism symptoms in children ages 3 to 12. About 100 kids will be randomly assigned to get either glutathione alone or glutathione plus monthly stem cell infusions for th…

This study tests a telehealth program that coaches parents of children with autism and overweight (ages 6-12) on healthy habits, compared to standard health education. About 140 families will participate. The goal is to see if parent-only training can improve children's weight an…

This study tests a mix of treatments for adolescents and adults with autism: their own stem cells, a strict diet, and a fecal transplant. The goal is to improve social skills, communication, and gut health. About 50 people will take part, and the study lasts one year.

This study tests a telemedicine tool called TAP that lets doctors assess toddlers for autism via video call. Researchers want to see if it works as well as in-person exams, especially for families who have trouble getting to a clinic. About 720 children aged 18 to 42 months and t…

This study looks at whether a probiotic called Saccharomyces boulardii can improve digestion, immune function, nutrition, and behavior in children aged 5 to 12 with autism spectrum disorder (ASD) who also have stomach issues. Researchers will compare the children's health during …

This study tests whether an internet-based job interview training program (Virtual Interview Training) helps autistic youth improve their interview skills and find jobs. About 200 participants will either use the training or continue with their usual services. The goal is to see …

This study tests a program that teaches parents of children with autism how to use positive behavior support techniques at home. The goal is to reduce challenging behaviors in children and lower parenting stress. The program is designed for families in South Punjab, Pakistan, usi…

This study tests a program called Regulating Together for 144 youth with autism who struggle with intense emotions. The program teaches skills to handle emotional ups and downs, with parents reporting changes. The goal is to improve daily coping and quality of life.

This pilot study explores whether laughter yoga can reduce depression and anxiety in children with autism spectrum disorder (ASD) and lower stress for their parents. About 66 families with children aged 8-12 will either practice laughter yoga or be placed on a waitlist. The goal …

This study looks at whether adding a speech-focused therapy (PROMPT) to a play-based therapy (JASPER) helps minimally verbal children with autism speak more words and combine them into phrases. Fifty-six children aged 3.5 to 5.5 years who use fewer than 20 words will receive eith…

This study tests a culturally adapted psychological therapy (YCMAP) to help prevent self-harm in young people with autism in Pakistan. Eighty participants aged 14-24 will receive either the therapy plus usual care or usual care alone. The main goal is to see if the therapy is fea…

This study tests a virtual reality program that lets children with autism watch themselves doing social behaviors and then practice them in a safe, virtual environment. The goal is to improve skills like eye contact, sharing attention, and using gestures. The trial includes 75 ch…

This study looks at the safety of a drug called ML-004 in 120 teens and adults with autism who have already taken it in a previous study. Participants will take the drug for a longer time so doctors can watch for side effects. The goal is not to cure autism but to see if the drug…

This study tests a thinking-skills training program for 40 autistic children aged 5 to 7 in South Korea. The program aims to improve skills like focus, memory, and self-control through fun computer games and parent activities. Researchers will check if the training is practical a…

This study tests a new behavior therapy for autistic teens aged 12–18 who struggle with irritability and aggression. The therapy teaches emotion regulation and coping skills to handle frustration. Researchers will measure changes in aggressive behavior and mood over time. The goa…

This study tests whether folinic acid (leucovorin), a drug already used to reduce side effects from chemotherapy, can improve language skills in children with autism spectrum disorder. About 56 children aged 5 to 17 will take the drug for 12 to 24 weeks. Researchers will measure …

This study tests whether a liquid form of leucovorin calcium can improve language and reduce core autism symptoms in young children. Researchers will enroll 80 children aged 2.5 to 5 years with autism and language delays. The study lasts about 26 weeks and measures changes in exp…

This study tests whether virtual reality games can help improve thinking skills—like memory, focus, and flexibility—in youth aged 8 to 18 with autism and/or ADHD. Half of the 50 participants will use a VR system for training, while the other half continues their usual care. The g…

This study tests whether benzodiazepines (a type of sedative) and electroconvulsive therapy (ECT) can safely reduce catatonic symptoms in 30 adolescents aged 10-19 with profound autism. Catatonia involves problems with movement, speech, and behavior. Participants receive medicati…

This study tests a home-based peer support program for 360 parents whose young child (age 2-6) was recently diagnosed with autism. The program provides guidance on finding services and coping with parenting challenges. The goal is to reduce parent stress and improve family well-b…

This study tests whether sulforaphane, a compound found in broccoli, can improve core symptoms of autism. The trial involves 48 males aged 13 to 30 with an autism diagnosis. Participants receive either sulforaphane or a placebo, and researchers measure changes in behavior and soc…

This study tests whether cannabidiol (CBD) can reduce severe behavior problems like aggression, self-harm, and repetitive actions in children with autism. About 42 boys aged 7-14 with severe autism and daily behavioral issues will receive both CBD and a placebo at different times…

This study tests a nurse-led sailing program for school-aged children with autism. 184 children aged 7 to 12 will either take part in a 6-day sailing program or do craft activities. Researchers will measure changes in resilience, quality of life, and mood to see if sailing helps.

This study tests a personalized, two-stage therapy approach for minimally verbal preschoolers with autism (ages 3-5) who use fewer than 20 words. Researchers will adjust the type and intensity of therapy based on each child's progress, aiming to improve spontaneous communication.…

This study tests a special sleep program for children with autism who have trouble sleeping. About 50 children ages 6 to 12 will take part in a 12-week program to improve their sleep habits, daytime behavior, and quality of life. The goal is to see if the program is easy to use a…

This study tests a Korean version of a social skills program called PEERS® for Preschoolers. It helps children aged 4 to 6 with autism learn how to make friends and interact with others. Parents are involved in coaching their kids. The goal is to see if the program improves socia…

This study tests a parent coaching and family navigation program for families of children (ages 1-5) recently diagnosed with autism. The program aims to reduce parental stress, boost confidence, and connect families to early services. About 200 families from specific California c…

This study tests a medication called pitolisant to see if it can improve social skills and behavior in male children and teenagers (ages 6 to 17) with autism spectrum disorder. The trial is double-blind and placebo-controlled, meaning some participants get the drug and some get a…

This study tests a 12-session program that trains parents of young children with autism (ages 18 months to 6 years) in low-resource households. Parents learn strategies to improve their child's social communication and behavior, while also getting support to reduce their own stre…

This study compares a home-based, tailored sleep therapy (CBT-I) with a web-based version to help caregivers of children with autism who have insomnia. About 80 caregivers will participate to see which approach is more acceptable and feasible. The goal is to improve sleep and red…

This study tests a 6-week virtual group program called Social ABCs for toddlers aged 12-42 months who show early signs of autism or social communication challenges. Parents learn strategies to encourage their child's vocalizations and shared smiling. The trial compares the progra…

This study planned to test whether sulforaphane, a compound found in broccoli, could improve social communication in people with autism spectrum disorder (ASD). Researchers aimed to enroll 50 people with ASD and 30 healthy volunteers, giving the ASD group sulforaphane capsules da…

This study tests whether a non-invasive brain stimulation technique called accelerated theta burst stimulation (aTBS) can safely reduce symptoms of depression in people with autism spectrum disorder (ASD). Researchers will compare the active treatment to a sham (placebo) procedur…

This study tests whether N-acetylcysteine (NAC), a well-tolerated nutritional supplement, can reduce restricted and repetitive behaviors in children with autism. Researchers will use brain scans and EEG to understand how NAC works. The study enrolls 144 children who previously to…

This study tests a 10-week parent training program called IMPACT for children with autism aged 1.5 to 6.5 years. The goal is to see if it improves social communication and daily living skills compared to usual care. Researchers will also use brain scans and eye-tracking to unders…

This study tests an investigational drug called ML-004 to see if it can help improve social communication in adolescents and adults with autism spectrum disorder. About 150 participants aged 12 to 45 will receive either ML-004 or a placebo for a set period. The main goal is to me…

This study looks at how melatonin, a common sleep aid, affects sleep spindles—brain waves linked to sleep quality and attention—in 30 children with autism aged 12-18. Researchers aim to understand if melatonin boosts these brain rhythms and improves sleep. The goal is to identify…

This study looks at whether a type of family therapy called Narrative Family Therapy can improve communication and well-being in families of children with autism (ages 8-18). Some families receive the therapy, while others play games designed to reflect family dynamics. Researche…

This study looks at how mitochondria, the energy powerhouses of cells, work in children with autism spectrum disorder. Researchers compare children with autism, mitochondrial disease, developmental delay, and typical development to find distinct patterns. The goal is to better un…

This study explores whether telehealth tools can make autism assessments and parent support more accessible for families with infants. About 80 families will use video-based evaluations and online resources to see if these methods reduce parent stress and improve confidence. The …

This study tests a 10-session online program called 'Our Love, Our Style' for autistic young adults aged 18-35 in South Korea. The program covers relationships, consent, and sexual health, adapted to Korean culture. Researchers will check if it improves knowledge and is easy to u…

This pilot study explores whether an online assessment battery can be used alongside complementary and integrative healthcare (CIH) for children with autism. About 20 children aged 3-12 with moderate to severe autism symptoms will participate. The main goal is to see if families …

This small pilot study is testing whether a home-based computer training program can help autistic children and teens improve their executive function skills, like attention, memory, and flexibility. Fifteen participants aged 8 to 17 will train at home for 30 minutes a day, five …

This study was designed to test whether vagus nerve stimulation (VNS) could help children and adults with autism and developmental disabilities. Researchers planned to measure changes in behavior, thinking, and body rhythms after daily VNS treatment for 1 to 3 months. However, th…

This study looks at how children with autism imitate gestures compared to typically developing children. Researchers want to understand why imitation is harder when two movements must be done at the same time. About 200 children aged 8 to 12 will watch videos and imitate gestures…

This study looks at whether taking common painkillers like paracetamol or ibuprofen during pregnancy can affect a child's brain development, behavior, and language skills. Researchers will follow 685 children from ages 2 to 4, using parent questionnaires to assess executive funct…

This study was designed to test a new way of teaching language to babies who have an older sibling with autism. The approach encourages babies to look at faces and mouths during play. The study was withdrawn before any participants were enrolled, so no results are available.

This study tests whether training public early intervention providers in a parent-led therapy can improve outcomes for children with autism. About 440 children and their caregivers will participate. The goal is to make specialized help more available during the critical early yea…

This study compares two suicide prevention programs designed specifically for autistic youth aged 12-24. The goal is to see which program better reduces suicidal thoughts and behaviors. Researchers will track participants for one year to measure effectiveness.

This study explores whether artificial intelligence (AI) can analyze a person's speech to help diagnose mental health conditions like depression, anxiety, ADHD, and autism. Researchers will collect speech samples from 500 people aged 16-60 who are being evaluated for mental healt…

This study looks at children and young adults (ages 4 to 21) with autism who are already using intranasal insulin as part of their regular care. Researchers will track changes in social skills, communication, and behavior over 6 months, and monitor for any side effects. The goal …

This study looks at how gut bacteria are linked to stress in children with autism or those who have faced tough experiences. Researchers will collect stool samples, saliva, and use eye-tracking to measure stress responses. 75 children ages 4-7 will take a probiotic powder for 4 w…

This study tests whether a special training program helps therapists and school staff better use two proven autism therapies for children. About 1,200 participants, including program leaders, providers, and parents, will take part. The goal is to see if extra coaching and motivat…

This study looks at whether a toolkit called PEACE can help therapists better coach parents of young children with autism. Researchers will enroll 200 therapists and 400 families in Philadelphia. The goal is to see if the toolkit improves how therapists teach parents to support t…

This study looks at how a cognitive behavioral program designed to improve flexibility in teens with autism (ages 14-18) may change the way they learn and how their brains work. Researchers will use brain scans and thinking tests to see if the program helps with learning and dail…

This study looks at how a single dose of escitalopram (Lexapro) changes brain activity in teens aged 12-17 with autism. Five participants will have brain scans while doing a reward-based eye-tracking task after taking the drug or a placebo. The goal is to understand how the drug …

This small pilot study aims to see if digital biomarkers—like heart rate and muscle movement measured by wearable devices—can help track changes in autism symptoms during treatment with sulforaphane, a compound found in vegetables. Ten males aged 13-30 with autism who previously …

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can change how adults with autism process social information. Researchers will measure brain activity and eye movements while participants look at faces,…