ANATOMIC STAGE IV BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE IV BREAST CANCER AJCC V8 explained in plain language.
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Custom-Made vaccine takes on tough breast cancer
⭐️ VACCINE ⭐️ Recruiting nowThis early-stage study tests a personalized vaccine made from a patient's own tumor, combined with immunotherapy drugs, for triple negative breast cancer. The goal is to see if the vaccine is safe and can help the immune system attack cancer cells. About 18 adults with various st…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Emory University • Aim: ⭐️ VACCINE ⭐️
Last updated May 26, 2026 04:17 UTC
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New vaccine shows promise in fighting Hard-to-Treat breast cancer
⭐️ VACCINE ⭐️ Recruiting nowThis study tests a vaccine called STEMVAC, given with chemotherapy, for people with a type of advanced breast cancer (triple-negative) that has spread. The vaccine is designed to train the immune system to attack cancer stem cells. About 20 adults with PD-L1 negative tumors will …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: ⭐️ VACCINE ⭐️
Last updated May 22, 2026 14:04 UTC
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Custom-Made vaccine targets tough cancers in early trial
⭐️ VACCINE ⭐️ Recruiting nowThis early-phase study is testing a personalized vaccine made from each patient's unique tumor mutations. The goal is to see if it is safe and can help the immune system fight advanced breast cancer, melanoma, and non-small cell lung cancer. About 25 adults whose cancers have spr…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Fred Hutchinson Cancer Center • Aim: ⭐️ VACCINE ⭐️
Last updated May 18, 2026 12:04 UTC
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Could a parasite drug boost cancer immunotherapy? new trial tests ivermectin combo
Disease control Recruiting nowThis study tests whether adding ivermectin (a common parasite drug) to standard immunotherapy can help shrink tumors in people with metastatic triple-negative breast cancer. About 34 adults whose cancer has spread will receive the combination. The goal is to find the best dose an…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Yuan Yuan • Aim: Disease control
Last updated May 26, 2026 04:26 UTC
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New drug cocktail targets Hard-to-Treat HER2 cancers
Disease control Recruiting nowThis early-stage trial tests the safety and best dose of combining two drugs—pidnarulex and trastuzumab deruxtecan—in people with advanced breast cancer or other solid tumors that have a protein called HER2. The study includes up to 36 adults whose cancer has spread, cannot be re…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 04:25 UTC
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New vaccine combo aims to boost immune attack on Hard-to-Treat breast cancer
Disease control Recruiting nowThis study tests whether adding a personalized vaccine (neoantigen vaccine) to a standard chemo-immunotherapy combination helps control metastatic triple-negative breast cancer better than the combination alone. About 70 adults with this aggressive, advanced breast cancer will re…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 04:18 UTC
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New hope for tough breast cancer: early trial combines three drugs to fight tumors
Disease control Recruiting nowThis early-stage trial tests a new drug called ASTX727 alongside standard chemotherapy (paclitaxel) and immunotherapy (pembrolizumab) for people with metastatic triple-negative breast cancer that cannot be removed by surgery. The goal is to find the safest dose and see if the com…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 04:18 UTC
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New vaccine shows promise in fight against advanced breast cancer
Disease control Recruiting nowThis study tests a vaccine called STEMVAC in people with hormone receptor-positive, HER2-negative breast cancer that has spread. The vaccine is designed to help the immune system attack cancer cells. It is given along with standard hormone therapy, a targeted drug, or chemotherap…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated May 26, 2026 04:16 UTC
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New triple-drug attack aims to shrink hard-to-treat breast cancer
Disease control Recruiting nowThis early-phase trial tests whether adding an experimental drug (ZEN003694) to standard chemotherapy and immunotherapy is safe for people with advanced triple-negative breast cancer that has spread. About 57 participants will receive the combination to find the best dose and che…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 04:15 UTC
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New radiation technique aims to control brain metastases while protecting memory
Disease control Recruiting nowThis study tests a radiation method that targets the entire brain and spinal cord to kill cancer cells that have spread there, while avoiding a memory-related area called the hippocampus. It is for people with breast or lung cancer that has reached the fluid and tissues around th…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated May 26, 2026 04:14 UTC
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Radiation may buy time for metastatic breast cancer patients on current therapy
Disease control Recruiting nowThis study looks at whether giving focused radiation to a few growing cancer spots can let patients with metastatic breast cancer stay on their current drug longer. About 45 adults whose cancer has started to progress after at least a year on first-line treatment will receive rad…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 26, 2026 04:12 UTC
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New radiation approach targets cancer in brain and spine fluid
Disease control Recruiting nowThis study tests a type of radiation therapy (craniospinal irradiation) for people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. The goal is to see if this treatment can help control the disease in the central nervous system.…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 26, 2026 04:12 UTC
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Electric field therapy worn like a vest shows promise against tough cancers
Disease control Recruiting nowThis early-phase study tests a wearable device that creates low-intensity electric fields to disrupt cancer cell growth, combined with standard drugs (cabozantinib or nab-paclitaxel plus atezolizumab). About 43 adults with advanced solid tumors in the abdomen or chest that have s…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 26, 2026 04:12 UTC
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New drug cocktail targets Hard-to-Treat cancers in early trial
Disease control Recruiting nowThis early-phase study tests the safety and best dose of two drugs—ZEN003694 and abemaciclib—given together to people with advanced breast cancer, NUT carcinoma, or other solid tumors that have spread or can't be removed by surgery. The goal is to see if the combination can shrin…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 03:55 UTC
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Can switching PARP inhibitors outsmart cancer? new trial aims to find out
Disease control Recruiting nowThis study is testing a drug called talazoparib in people with advanced solid tumors that have specific DNA repair gene mutations. The goal is to see if this PARP inhibitor can shrink tumors or slow their growth, even in patients who have already tried a similar drug. About 36 ad…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 03:54 UTC
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Custom-Made cancer vaccine shows promise in advanced tumors
Disease control Recruiting nowThis study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps the immune syst…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 22, 2026 14:04 UTC
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New combo attack on hard-to-treat breast cancer shows promise in early trial
Disease control Recruiting nowThis study tests whether adding high-dose radiation to standard immunotherapy (pembrolizumab) and chemotherapy can help people with a specific type of advanced breast cancer (PD-L1 positive, triple-negative) that has spread. About 29 participants will receive this combination to …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Emory University • Aim: Disease control
Last updated May 22, 2026 14:03 UTC
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New combo attack on liver tumors in advanced breast cancer shows promise
Disease control Recruiting nowThis study tests whether combining an immunotherapy drug (cemiplimab) with a procedure that delivers tiny radioactive beads directly to liver tumors (Y90 radioembolization) can help people with breast cancer that has spread to the liver. The goal is to boost the immune system's a…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 22, 2026 13:50 UTC
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New vaccine combo aims to shrink breast cancer brain tumors
Disease control Recruiting nowThis study tests a combination of two treatments for people with breast cancer that has spread to the brain. One is a vaccine made from the patient's own immune cells, designed to help the body recognize and attack cancer. The other is a drug called pembrolizumab, which helps the…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated May 20, 2026 11:55 UTC
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New radiation approach may let breast cancer patients keep current therapy longer
Disease control Recruiting nowThis study tests whether a precise type of radiation (SBRT) can control limited cancer growth in people with ER+ metastatic breast cancer, allowing them to continue their current medication instead of switching. It also evaluates a special PET scan (FES) to better detect where th…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 19, 2026 12:01 UTC
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Measles virus turned against breast cancer tumors in new trial
Disease control Recruiting nowThis early-stage trial tests a modified measles virus (MV-s-NAP) injected directly into tumors of people with metastatic breast cancer. The virus is designed to kill cancer cells and boost the immune system. Researchers aim to find the safest dose and see if it shrinks tumors. Ab…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 18, 2026 12:08 UTC
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New drug targets Hard-to-Treat cancers with specific mutations
Disease control Recruiting nowThis study tests a drug called avapritinib in people with advanced solid tumors that have spread and have specific gene changes (CKIT or PDGFRA mutations). The drug works by blocking enzymes that help cancer cells grow. The goal is to see if avapritinib can shrink or control thes…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 18, 2026 12:07 UTC
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Promising combo targets Hard-to-Treat breast cancer
Disease control Recruiting nowThis study tests whether adding tamoxifen to a standard chemotherapy drug (liposomal doxorubicin) can shrink tumors in people with advanced triple-negative breast cancer that has spread or cannot be removed by surgery. About 30 adults who have already tried at least two other tre…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated May 18, 2026 12:04 UTC
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Smart dosing trial aims to outsmart metastatic breast cancer
Disease control Recruiting nowThis study tests a new way of giving the chemotherapy drug capecitabine to people with metastatic ER-positive, HER2-negative breast cancer. Instead of a fixed dose, the dose is adjusted based on how the tumor responds on scans and blood tests. The goal is to better control the ca…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 18, 2026 12:01 UTC
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New proton radiation trial aims to extend survival in advanced cancer patients
Disease control Recruiting nowThis study tests if a precise type of proton radiation (pCSI) can help people with breast or lung cancer that has spread to the fluid-filled space around the brain and spinal cord live longer than standard x-ray radiation. About 115 participants will be randomly assigned to one o…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated May 15, 2026 11:57 UTC
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New study tests cheaper drug for ovarian suppression in breast cancer
Disease control Recruiting nowThis study compares two drugs, leuprolide and goserelin, to see how well they lower estrogen in premenopausal women with breast cancer. Both drugs stop the ovaries from making estrogen, which can fuel cancer growth. The trial will test if leuprolide works as well as goserelin. Ab…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control
Last updated May 12, 2026 13:42 UTC
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New hope for hard-to-treat breast cancer: drug combo targets resistance
Disease control Recruiting nowThis study tests whether adding another drug (cediranib or AZD6738) to the PARP inhibitor olaparib can shrink tumors or slow cancer growth in people with advanced BRCA-mutated breast cancer that has stopped responding to PARP inhibitors. About 60 adults with HER2-negative, BRCA-p…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 29, 2026 15:05 UTC
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New scan may spot hidden brain tumors in breast cancer patients
Diagnosis Recruiting nowThis study is testing a special PET/MRI scan that uses a radioactive tracer to find HER2-positive breast cancer that has spread to the brain. The goal is to see if the scan can show which brain tumors will respond to a standard chemotherapy drug. About 10 women with metastatic br…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE4 • Sponsor: City of Hope Medical Center • Aim: Diagnosis
Last updated May 26, 2026 04:17 UTC
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Brain metastases trial tests Split-Dose radiation for better tumor control
Symptom relief Recruiting nowThis study compares two types of radiation therapy for people whose cancer has spread to the brain. One group gets a single high dose of radiation, while the other gets three smaller doses over several days. The goal is to see if the three-dose approach works better at controllin…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Symptom relief
Last updated May 26, 2026 04:27 UTC
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Can a Hair-Growing drug fix Chemo-Free hair loss?
Symptom relief Recruiting nowThis study tests whether minoxidil (a hair-growth drug) can reduce hair loss caused by hormone therapy in breast cancer patients. About 50 women with stages I-IV breast cancer who are on hormone therapy and have noticed hair thinning will take either a pill or apply a solution da…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: EARLY_PHASE1 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated May 26, 2026 04:27 UTC
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Smart bag and texts aim to boost Pill-Taking in advanced breast cancer
Symptom relief Recruiting nowThis study tests a system called CONCURxP that uses a special medication bag (WiseBag) and text message reminders to help people with metastatic breast cancer take their CDK4/6 inhibitor pills correctly. About 410 patients will either use the bag alone or the bag plus text remind…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Symptom relief
Last updated May 26, 2026 04:11 UTC
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New hope for seniors: tolerability trial for advanced breast cancer drug
Symptom relief Recruiting nowThis study looks at how well older adults (70+) with hormone receptor positive metastatic breast cancer tolerate the drug abemaciclib after other treatments have stopped working. The main goal is to track side effects and see if the drug can be safely combined with hormone therap…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Symptom relief
Last updated May 20, 2026 11:57 UTC
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New ultrasound marker could make breast cancer surgery more precise
Knowledge-focused Recruiting nowThis early-stage study tests a new type of marker that shows up better on ultrasound for people with breast cancer that has spread to lymph nodes. The marker is placed in the lymph node to help doctors find and remove the right node during surgery. The goal is to see if this mark…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 26, 2026 04:27 UTC
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New PET tracer could reveal hidden cancer treatment response
Knowledge-focused Recruiting nowThis study is testing a new radioactive tracer called [18F]FTT to see if it can improve PET scans for people with metastatic breast cancer. The goal is to better detect whether standard treatments like PARP inhibitors (with or without immunotherapy) are working. About 22 particip…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: University of Washington • Aim: Knowledge-focused
Last updated May 26, 2026 04:14 UTC
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Genetic matchmaking for cancer: ComboMATCH trial aims to personalize therapy
Knowledge-focused Recruiting nowThis study screens people with advanced solid tumors to see if their cancer has specific genetic changes. Based on those results, they may be matched to a treatment trial that targets their tumor's unique genetics. The goal is to learn how well these targeted combinations work an…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated May 26, 2026 04:11 UTC
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700 breast cancer patients enrolled to unlock secrets of CDK4/6 drug resistance
Knowledge-focused Recruiting nowThis study follows 700 adults with advanced or metastatic breast cancer who are taking CDK4/6 inhibitors (ciclibs). Researchers collect blood, tissue, and fluid samples to understand how the cancer responds and why resistance develops. The goal is to improve treatment decisions a…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Roswell Park Cancer Institute • Aim: Knowledge-focused
Last updated May 26, 2026 03:57 UTC
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Researchers track immune cells in HER2 breast cancer patients
Knowledge-focused Recruiting nowThis study looks at blood and tumor samples from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. The goal is to learn how the immune system reacts to these treatments. No new therapy is being tested; instead, researcher…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 22, 2026 13:53 UTC
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Scientists use live camera to peek inside tumors during surgery
Knowledge-focused Recruiting nowThis study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to see how these vessels work, which could help decide if a patient's tumor is likely to respond to certain treatments.…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 22, 2026 13:51 UTC
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Can a PET scan predict breast cancer drug success?
Knowledge-focused Recruiting nowThis study tests whether a special PET scan can predict if a drug combination (abemaciclib plus hormone therapy) will work for people with advanced hormone receptor-positive, HER2-negative breast cancer. About 60 participants will get the treatment and have imaging scans to see i…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Knowledge-focused
Last updated May 18, 2026 12:08 UTC
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Blood test monitoring may be as effective as scans for advanced breast cancer
Knowledge-focused Recruiting nowThis study is testing whether using simple blood tests (tumor markers) to decide when to do scans is as good as the usual approach of regular scans for people with advanced hormone receptor-positive breast cancer. About 739 participants will be randomly assigned to either blood t…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: SWOG Cancer Research Network • Aim: Knowledge-focused
Last updated May 18, 2026 12:01 UTC
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Researchers ask: what do advanced breast cancer patients really need?
Knowledge-focused Recruiting nowThis study talks to 50 people with advanced breast cancer to learn what has helped them, what has been hard, and what kind of support they still need. It does not test any new drug or treatment. The goal is to design better supportive care programs for the future.
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated May 14, 2026 12:02 UTC
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Electric field device tested for spine cancer spread
Knowledge-focused Recruiting nowThis study tests whether a portable device that creates electric fields is safe and practical for treating cancer that has spread to the lining of the spine. It includes up to 5 adults with breast or lung cancer that has spread to the spinal fluid and spine. The goal is to see if…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Apr 26, 2026 19:35 UTC