ANATOMIC STAGE IV BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE IV BREAST CANCER AJCC V8 explained in plain language.
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Targeted drug trial aims to starve advanced cancers by blocking their DNA repair
Disease control Recruiting nowThis study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific genetic mutations that affect how cells repair damaged DNA. The trial will enroll about 36 adults with various advanced solid tumors (like breast, ovarian, …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 04, 2026 02:20 UTC
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New radiation technique aims to fight advanced cancer while sparing memory
Disease control Recruiting nowThis study is testing a specialized form of radiation therapy for people with breast or lung cancer that has spread to the fluid surrounding the brain and spinal cord. The treatment aims to target cancer cells throughout this fluid while carefully avoiding a key memory center in …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated Apr 03, 2026 14:43 UTC
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Custom-Made vaccine trial targets advanced cancers
Disease control Recruiting nowThis early-stage study is testing a personalized vaccine designed to train the immune system to attack a patient's specific cancer. It is for adults with advanced breast cancer, melanoma, or non-small cell lung cancer that has continued to grow despite standard treatments. The ma…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Apr 03, 2026 14:42 UTC
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New hope for beating Drug-Resistant breast cancer
Disease control Recruiting nowThis study is testing two new drug combinations for people with advanced breast cancer linked to BRCA gene mutations, whose cancer has started growing again despite taking standard PARP inhibitor drugs. It aims to see if adding a second drug to olaparib can shrink tumors and cont…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 03, 2026 14:42 UTC
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Zapping spinal cancer with a portable device
Disease control Recruiting nowThis study is testing if a portable device that creates electric fields is safe and practical for treating cancer that has spread to the lining of the spinal cord. Up to 5 patients with advanced breast or lung cancer will wear the device for most of the day to see if it can help …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Apr 03, 2026 14:41 UTC
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New oral drug trial aims to boost cancer treatment for Tough-to-Treat breast cancer
Disease control Recruiting nowThis early-stage trial is testing the safety and best dose of a new oral drug called ASTX727 when given alongside standard chemotherapy (paclitaxel) and immunotherapy (pembrolizumab) for metastatic triple-negative breast cancer. The study aims to see if adding ASTX727 can help sh…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 02, 2026 14:58 UTC
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Custom cancer vaccine designed to train your own immune system
Disease control Recruiting nowThis study is testing a new, personalized vaccine designed to teach the body's immune system to recognize and attack a patient's specific cancer. It is being given alongside an existing immunotherapy drug (pembrolizumab) to adults with advanced solid tumors that have spread. The …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Apr 02, 2026 14:58 UTC
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New vaccine trial aims to train immune system to fight spreading breast cancer
Disease control Recruiting nowThis study is testing whether adding an experimental vaccine called STEMVAC to standard treatments helps control advanced breast cancer that has spread. The vaccine is designed to teach the body's immune system to recognize and attack cancer cells. Researchers will enroll 40 pati…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated Apr 02, 2026 14:57 UTC
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Smart pillbox aims to stop patients forgetting vital cancer pills
Disease control Recruiting nowThis study is testing whether a smart pillbox, combined with text message reminders, can help people with advanced breast cancer remember to take their oral medication correctly. The goal is to see if this technology helps patients stick to their complex treatment schedule better…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Scientists test engineered measles virus to fight advanced breast cancer
Disease control Recruiting nowThis early-stage trial is testing a modified measles virus (MV-s-NAP) that is injected directly into tumors in patients with metastatic breast cancer. The goal is to see if the virus can safely infect and kill cancer cells while also stimulating the patient's immune system to att…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Zap and stay: radiation may let patients keep current breast cancer treatment longer
Disease control Recruiting nowThis study is testing a precise, high-dose radiation treatment for people with estrogen receptor-positive (ER+) breast cancer that has spread to a few new spots in the body. The goal is to see if zapping those few spots with radiation allows patients to safely continue their curr…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Scientists test novel drug duo in fight against Tough-to-Treat cancers
Disease control Recruiting nowThis early-phase study aims to find a safe and tolerable dose of a new drug combination for people with advanced breast cancer and other solid tumors that have a protein called HER2. The trial will test pidnarulex, which aims to stop tumor cell growth, together with an existing t…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Zapping tumors: wearable device tested with drugs for tough cancers
Disease control Recruiting nowThis early-stage trial is testing the safety of combining a wearable device that uses electric fields to disrupt cancer cells with different drug combinations. It is for adults with advanced cancers in the abdomen or chest that have spread and who have run out of standard treatme…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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New vaccine trial aims to train immune system to fight breast cancer in the brain
Disease control Recruiting nowThis study is testing a two-part treatment for breast cancer that has spread to the brain. Patients receive a personalized vaccine made from their own immune cells, combined with an immunotherapy drug called pembrolizumab. The goal is to see if this combination can shrink brain t…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Scientists test Custom-Made vaccine to fight spreading breast cancer
Disease control Recruiting nowThis study is testing whether adding a personalized vaccine to standard immunotherapy and chemotherapy helps control advanced triple-negative breast cancer that has spread. It will compare two groups of about 70 patients total: one gets the vaccine plus standard drugs, the other …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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New study tests which hormone blocker works best for younger breast cancer patients
Disease control Recruiting nowThis study compares two different hormone-blocking treatments (leuprolide and goserelin) for premenopausal women with breast cancer. Both drugs work by reducing estrogen production, which can help slow or stop cancer growth. Researchers will measure how well each treatment lowers…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Major trial uses genetic blueprint to find the right drug combo for advanced cancer
Disease control Recruiting nowThis trial is a large screening program that matches patients with advanced solid tumors to one of many smaller treatment studies. It uses genetic testing on a patient's tumor to find specific mutations. Patients are then assigned to a drug combination designed to target those mu…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Brain cancer radiation showdown: one big dose vs. three smaller ones
Disease control Recruiting nowThis study aims to find the best radiation method for treating cancer that has spread to the brain. It compares giving one large radiation dose versus spreading the same total radiation over three smaller treatments. Researchers want to see which approach better controls the brai…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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First human trial tests new drug duo against aggressive cancers
Disease control Recruiting nowThis early-stage study aims to find the safest dose of two oral drugs—ZEN003694 and abemaciclib—when given together to patients with advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 45 adults and teens (12+) with specific cancers, inc…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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New combo therapy aims to shrink tough liver tumors
Disease control Recruiting nowThis study is testing a combination treatment for breast cancer that has spread to the liver. It pairs an immunotherapy drug (cemiplimab) that helps the immune system fight cancer with a targeted radiation treatment (Y90) delivered directly to liver tumors. The main goal is to se…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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Scientists test 'One-Two Punch' against Tough-to-Treat cancers
Disease control Recruiting nowThis early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced solid tumors that have a specific marker called HER2. The treatment pairs an existing targeted cancer drug with a new pill that aims to block cancer cells' ability to…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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New hope for Tough-to-Treat breast cancer: old drugs, new combo
Disease control Recruiting nowThis study is testing whether combining two existing drugs—tamoxifen and a special form of doxorubicin—can help control advanced triple-negative breast cancer that has spread or cannot be removed by surgery. It is for patients whose cancer has continued to grow despite at least t…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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Doctors test custom cancer vaccine to train immune system
Disease control Recruiting nowThis early-stage trial is testing a new, personalized vaccine for triple-negative breast cancer (TNBC). The vaccine is custom-made from a piece of a patient's own tumor and is designed to teach their immune system to recognize and attack the cancer. Researchers are studying the v…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Emory University • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New vaccine trial aims to train immune system to fight aggressive breast cancer
Disease control Recruiting nowThis study is testing whether a new vaccine called STEMVAC, when given alongside standard chemotherapy, can help control advanced triple-negative breast cancer. The vaccine is designed to teach the body's immune system to recognize and attack cancer cells. Researchers will enroll…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Scientists test Triple-Threat attack on tough breast cancer
Disease control Recruiting nowThis early-stage trial is testing the safety of a new three-drug combination for people with advanced triple-negative breast cancer. It combines a new experimental pill (ZEN003694) with an immunotherapy drug (pembrolizumab) and a standard chemotherapy (nab-paclitaxel). The main g…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Common drug ivermectin tested in new fight against aggressive breast cancer
Disease control Recruiting nowThis early-stage study is testing whether adding the drug ivermectin to standard immunotherapy helps shrink tumors in people with advanced triple-negative breast cancer that has spread. The main goals are to find a safe dose and see if the combination is more effective than immun…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Yuan Yuan • Aim: Disease control
Last updated Mar 24, 2026 12:01 UTC
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Targeted pill trial aims to control advanced cancers by blocking key growth signals
Disease control Recruiting nowThis study is testing an oral medication called avapritinib for people with advanced solid tumors that have spread and have specific genetic changes (mutations in the CKIT or PDGFRA genes). The drug aims to block the signals that help these tumor cells grow, potentially controlli…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 23, 2026 15:29 UTC
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Doctors test 'Adaptive' chemo that adjusts dose based on tumor response
Disease control Recruiting nowThis study is testing a flexible approach to chemotherapy for advanced breast cancer that has spread. Researchers want to see if adjusting the dose of the drug capecitabine based on how the tumor responds—using scans and blood tests—can help control the cancer longer while possib…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 23, 2026 15:29 UTC
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New proton beam trial aims to extend life for advanced cancer patients
Disease control Recruiting nowThis study is for people with breast or non-small cell lung cancer that has spread to the fluid-filled space around the brain and spinal cord. It compares two types of radiation therapy to see which one helps patients live longer. One method targets only the specific areas causin…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Mar 16, 2026 15:27 UTC
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New hope for seniors battling advanced breast cancer
Disease control Recruiting nowThis study is testing how well older adults tolerate a breast cancer drug called abemaciclib. It is for people aged 70 and older whose hormone-positive breast cancer has spread and worsened after previous treatments. The main goal is to understand the side effects and safety of t…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 13, 2026 15:06 UTC
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New radiation approach targets cancer in brain and spine fluid
Disease control Recruiting nowThis study is testing a specialized radiation treatment for patients whose breast or lung cancer has spread to the fluid surrounding the brain and spinal cord. The treatment aims to target all areas where this type of cancer spread might occur. Researchers want to see if this app…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 09, 2026 14:22 UTC
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Zapping spots to keep cancer drugs working
Disease control Recruiting nowThis study is for people with metastatic breast cancer whose current medication is working well but who have a few new spots of cancer growth. Researchers want to see if using very precise, high-dose radiation on just those few spots can control them, allowing patients to safely …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 04, 2026 15:30 UTC
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New brain scan could predict cancer treatment success
Diagnosis Recruiting nowThis study is testing a new type of PET/MRI scan to see if it can help doctors better understand and predict how well a standard breast cancer treatment will work when the cancer has spread to the brain. Researchers will give the scan to 10 women with this specific type of advanc…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE4 • Sponsor: City of Hope Medical Center • Aim: Diagnosis
Last updated Mar 30, 2026 14:33 UTC
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New scan aims to see inside tumors, predict treatment success
Diagnosis Recruiting nowThis study is testing a new type of PET scan to see if it can better show how well a patient's breast cancer is responding to certain targeted drug treatments. The scan uses a special tracer that lights up a specific protein in cancer cells. Researchers want to see if this new sc…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: University of Washington • Aim: Diagnosis
Last updated Mar 30, 2026 14:32 UTC
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Mayo clinic tests 'Twinkling' marker to improve breast cancer node detection
Diagnosis Recruiting nowThis early-stage study is testing a new type of biopsy marker designed to be easier for surgeons to see on ultrasound scans during breast cancer operations. The marker is placed in a cancerous lymph node before treatment and is meant to help guide surgeons to the correct node for…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Mar 02, 2026 15:21 UTC
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New hope for hair loss in breast cancer patients
Symptom relief Recruiting nowThis early study is testing whether a pill or a foam version of the hair growth drug minoxidil works better to treat hair loss caused by hormone therapy in breast cancer patients. It will involve about 50 women with stage I-IV breast cancer who are experiencing this side effect. …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: EARLY_PHASE1 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated Mar 30, 2026 14:33 UTC
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Researchers ask: what do advanced breast cancer patients really need?
Knowledge-focused Recruiting nowThis study aims to understand the experiences and support needs of people living with advanced breast cancer. Researchers will survey and interview 50 patients and caregivers to learn what has helped them, what has been difficult, and what kind of help they still need. The goal i…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Apr 02, 2026 14:57 UTC
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New scan could tell doctors which breast cancer drugs will work
Knowledge-focused Recruiting nowThis study is testing whether a special type of PET scan can predict if a breast cancer drug called abemaciclib will work for patients with advanced hormone-positive, HER2-negative breast cancer. Researchers will give 60 participants this special scan before and after a brief hor…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:35 UTC
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Scientists watch Cancer's blood supply live during surgery
Knowledge-focused Recruiting nowThis study aims to learn more about the tiny blood vessels that feed solid tumors. Researchers will use a special microscope during a patient's standard cancer surgery to see these vessels in real time. The goal is to understand how tumor blood flow works and if it relates to how…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:39 UTC
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Scientists track Body's hidden battle against breast cancer during treatment
Knowledge-focused Recruiting nowThis study aims to understand how the immune system reacts during standard treatments for HER2-positive breast cancer. Researchers will collect blood and tissue samples from 230 patients with stage I-IV breast cancer who are receiving or have received anti-HER2 drugs like trastuz…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:38 UTC
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Scientists track 700 cancer patients to crack treatment resistance code
Knowledge-focused Recruiting nowThis study follows 700 patients with advanced breast cancer who are taking specific cancer drugs called CDK4/6 inhibitors. Researchers will collect blood and tissue samples to understand why some patients respond well to treatment while others develop resistance. The goal is to l…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Roswell Park Cancer Institute • Aim: Knowledge-focused
Last updated Mar 20, 2026 14:48 UTC
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Scientists build a living library of cancer to unlock treatment secrets
Knowledge-focused Recruiting nowThis study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Mar 17, 2026 13:09 UTC