ANATOMIC STAGE IV BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE IV BREAST CANCER AJCC V8 explained in plain language.
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Scientists test Cancer-Fighting virus in advanced breast cancer patients
Disease control OngoingThis early-stage trial is testing a new treatment for metastatic triple-negative breast cancer, a difficult-to-treat form of the disease. Researchers are injecting a specially engineered virus directly into tumors to see if it can safely break down cancer cells and stimulate the …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Apr 03, 2026 14:43 UTC
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New cancer drug combo enters first human safety tests
Disease control OngoingThis is an early-stage safety study testing a new drug called BAY 1895344 when given with standard chemotherapy drugs (cisplatin with or without gemcitabine). The main goals are to find the safest dose and understand the side effects in people with advanced solid tumors that have…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 03, 2026 14:41 UTC
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New drug duo aims to stall aggressive breast cancer
Disease control OngoingThis study is testing whether adding a new drug called copanlisib to a standard chemotherapy (eribulin) is safe and more effective for treating advanced triple-negative breast cancer that has spread. It will involve about 24 patients whose cancer has progressed after prior treatm…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 02, 2026 14:56 UTC
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New hope for slowing advanced breast cancer
Disease control OngoingThis large, late-stage trial is testing whether adding a new drug called entinostat to standard hormone therapy (exemestane) works better than the hormone therapy alone. It's for people whose hormone-sensitive, advanced breast cancer has continued to grow despite prior treatment.…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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New combo attack on advanced breast cancer
Disease control OngoingThis study is testing whether adding an immunotherapy drug (atezolizumab) to a targeted cancer drug (olaparib) works better than the targeted drug alone for people with advanced breast cancer that has a specific genetic flaw (BRCA mutation). The goal is to see if the combination …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Scientists test new 'In-Situ' cancer vaccine strategy
Disease control OngoingThis early-stage trial is testing the safety of a new combination treatment for people with advanced cancers that have spread and cannot be removed by surgery. Doctors inject immune-stimulating drugs directly into a tumor, then give a small dose of radiation to that same spot. Th…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Southern California • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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New hope for Tough-to-Treat breast cancer? scientists test Triple-Threat drug combo
Disease control OngoingThis study is testing if adding a new drug called copanlisib to the standard two-drug treatment (fulvestrant and abemaciclib) is more effective for advanced breast cancer that has stopped responding to hormone therapy. It will involve about 24 patients with hormone-positive, HER2…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Radioactive drug joins fight against breast cancer in bones
Disease control OngoingThis study is testing whether adding a radioactive drug called Radium-223 to standard chemotherapy (paclitaxel) works better for people with breast cancer that has spread to their bones. The radioactive drug travels to the bones and aims to kill cancer cells there, potentially sl…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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New drug combo tested for Tough-to-Treat advanced cancers
Disease control OngoingThis early-stage study is testing a new combination of two drugs, AZD8186 and docetaxel, for patients with advanced solid tumors that have specific genetic changes (PTEN or PIK3CB mutations). The main goals are to find the safest and most effective dose and to understand the side…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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Estrogen tested as surprising weapon against aggressive breast cancer
Disease control OngoingThis study is testing whether estradiol, a form of estrogen, can help control advanced triple-negative breast cancer that has a specific biomarker called ER beta. Researchers are giving estradiol pills to 8 postmenopausal women whose cancer has spread and seeing if their tumors s…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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New combo therapy trial offers hope for HIV patients with advanced cancers
Disease control OngoingThis is a small, early-stage safety study testing a combination of two cancer drugs, nivolumab and cabozantinib, in people living with HIV who have advanced solid tumors. The main goal is to see if the two-drug combination is safe and tolerable for this specific patient group. Re…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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New hope for Tough-to-Treat breast cancer
Disease control OngoingThis study is testing whether adding a new experimental drug, TVB-2640, to standard treatments can help control advanced HER2-positive breast cancer that has spread and is no longer responding to the usual therapies. It involves a small group of patients whose cancer has progress…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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Doctors use genetic blueprint to fight advanced cancers
Disease control OngoingThis study is testing a personalized treatment method for people with advanced breast, prostate, ovarian, pancreatic, or sarcoma cancers that have spread. Doctors analyze each patient's tumor using genetic and protein tests to understand how the cancer is changing and which drugs…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Mar 23, 2026 15:18 UTC
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Double attack on tough cancers: early trial tests combo for patients out of options
Disease control OngoingThis early-stage trial is testing a combination of two drugs, niraparib and dostarlimab, for people with advanced breast, ovarian, pancreatic, or related cancers that have a specific genetic change (BRCA mutation) and have stopped responding to standard treatments. The goal is to…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Washington • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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Scientists test new Triple-Threat attack on tough cancers
Disease control OngoingThis early-stage study is testing the safety and best dose of a three-drug combination (entinostat, nivolumab, and ipilimumab) for people with advanced solid tumors that have spread and are hard to treat. The goal is to see if boosting the immune system with two drugs while using…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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New scan aims to spot if breast cancer treatment is working sooner
Diagnosis OngoingThis study is testing whether a special type of PET/CT scan can better measure how well treatment is working for breast cancer that has spread to the bones. About 138 patients with this type of advanced cancer will get the scan before starting treatment and again 12 weeks later. …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Diagnosis
Last updated Apr 01, 2026 14:41 UTC
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New drug trial aims to shield cancer patients from Chemo's painful side effects
Symptom relief TerminatedThis clinical trial is testing whether a substance called GM1 can prevent or reduce nerve damage caused by a common chemotherapy drug, paclitaxel. The study involves about 100 people with metastatic breast cancer who are scheduled to receive paclitaxel treatment. Participants are…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Symptom relief
Last updated Apr 04, 2026 02:21 UTC
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Virtual support aims to ease cancer Patients' fears
Symptom relief TerminatedThis study aimed to test an online mental health program designed to help women with advanced breast or gynecologic cancers manage their fear of the cancer returning or getting worse. It planned to compare this virtual program to standard educational resources. The goal was to se…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: City of Hope Medical Center • Aim: Symptom relief
Last updated Apr 03, 2026 14:41 UTC
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Can blood tests help tame Chemo's painful side effects?
Knowledge-focused TerminatedThis study aims to see if doctors can reliably measure the amount of a common chemotherapy drug, paclitaxel, in a patient's blood. The goal is to learn if tracking these drug levels can help doctors adjust doses to better fight cancer while reducing a major side effect: nerve dam…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Wake Forest University Health Sciences • Aim: Knowledge-focused
Last updated Apr 03, 2026 14:43 UTC
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Scientists hunt clues in breast cancer Patients' blood and tissue
Knowledge-focused TerminatedThis study aims to collect tissue samples, blood, and medical information from 300 patients with advanced breast cancer that has spread. Researchers will analyze these samples to understand why breast cancer spreads to other parts of the body and why different patients respond di…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:27 UTC
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Genetic testing trial aims to match breast cancer patients with right treatments
Knowledge-focused OngoingThis study is testing whether analyzing the genetic makeup of breast tumors can help predict which standard treatments will work best for individual patients. Researchers are enrolling 1,100 people with early-stage breast cancer to see if genetic testing can accurately identify t…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Mar 19, 2026 14:56 UTC
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Can a simple video unlock better cancer care decisions?
Knowledge-focused OngoingThis study is testing whether a short educational video can help patients with advanced cancer better understand tumor genomic testing. It involves 243 adults with metastatic breast or lung cancer who are already scheduled for this type of testing. Researchers will measure if wat…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Mar 10, 2026 12:53 UTC