Smart drug targets breast cancer in the brain

NCT ID NCT04647916

Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase II trial tests a drug called sacituzumab govitecan in 44 patients with HER2-negative breast cancer that has spread to the brain. The drug is a targeted antibody that delivers chemotherapy directly to cancer cells. The goal is to see if it can shrink brain tumors or slow the cancer's growth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: sacituzumab govitecan (a targeted antibody carrying chemotherapy)
What this could lead to: If it works, this could offer a new treatment option for patients with HER2-negative breast cancer that has spread to the brain, potentially shrinking brain tumors and extending survival.
What could go wrong: This is a small, early-phase trial with only 44 participants, so results may not apply to everyone. The drug can cause side effects like nausea, fatigue, and low blood cell counts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 44 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2021

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must have histologically confirmed HER2-negative (per 2018 American Society of Clinical Oncology \[ASCO\]/College of American Pathologists \[CAP\] joint guideline) invasive breast cancer that has metastasized to the brain. NOTE: Pathology report must confirm HER2-negative invasive breast cancer. Brain metastases must be confirmed by radiology report * Participants must have an magnetic resonance imaging (MRI) of the brain within 28 days prior to registration and must have central nervous system metastases with at least one measurable brain metastasis \>= 1.0 cm in size (per RANO-BM) that has not been irradiated, or has progressed despite prior radiation therapy (in the opinion of the treating physician). In the rare case that a previously irradiated brain metastasis is the sole target lesion and if there is concern about possible radiation necrosis, patient is eligible only if there is clear progression in the previously radiated lesion. Computed tomography (CT) of the head cannot substitute for brain MRI. All central nervous system (CNS) disease must be assessed and documented on the S2007 Brain Metastases Baseline Tumor Assessment Form * Participants may have measurable or non-measurable extracranial disease. All measurable disease must be assessed within 28 days prior to registration; all non-measurable disease must be assessed within 42 days prior to registration. Participants are NOT required to have extracranial disease, but must have scans done to document disease status at baseline. All extracranial disease must be assessed and documented on the Baseline Tumor Assessment Form (Response Evaluation Criteria in Solid Tumors \[RECIST\] 1.1). NOTE: Brain lesions should not be included on the Baseline Tumor Assessment Form (RECIST 1.1) for this study * Participants must have had CNS progression after previous CNS-directed therapy (radiation therapy, surgery, or any combination of therapy) * Participants must have resolution of adverse event(s) of the most recent prior systemic anti-cancer therapy to \< grade 2, with the exception of alopecia and =\< grade 2 neuropathy, which are allowed * Participants with a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Participants must have Zubrod performance status 0 or 1 * Participants must have history and physical exam obtained within 21 days prior to registration * Absolute neutrophil count (ANC) \>= 1,500/mcL (obtained within 21 days prior to registration) * Platelet count \>= 100,000/mcL (obtained within 21 days prior to registration) * Hemoglobin \>= 9.0 g/dL (obtained within 21 days prior to registration) * Total bilirubin =\< 1.5 times institutional upper limit of normal (ULN) (obtained within 21 days prior to registration) * Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =\< 3 x institutional ULN (obtained within 21 days prior to registration) * Participants must have a serum creatinine =\< 1.5 times the institutional upper limit of normal (IULN) OR measured OR calculated creatinine clearance \>= 30 mL/min using the following Cockcroft-Gault Formula. This specimen must have been drawn and processed within 21 days prior to registration * Participants must have adequate cardiac function. Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification, and must be class 2B or better * Participants must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System * Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines Exclusion Criteria: * Participants must not have had more than 2 seizures within 28 days prior to registration * Participants must not have received systemic therapy (including small-molecule kinase inhibitors) or non-cytotoxic hormonal therapy (e.g., tamoxifen) within 7 days prior to registration * Participants must not have received anti-cancer biologic agents (antibodies, immune modulators, vaccines, cytokines) within 21 days prior to registration * Participants must not have received nitrosoureas or mitomycin C within 42 days, metronomic/protracted low-dose chemotherapy within 14 days, or other cytotoxic chemotherapy within 28 days prior to registration * Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral agents that are strong CYP3A4 inhibitors or inducers and who are unwilling or unable to change to antiretroviral therapies without such interactions are ineligible because of the potential for pharmacokinetic interactions with sacituzumab govitecan (IMMU-132) * Due to potential drug interactions of anti-retroviral drugs with sacituzumab govitecan (IMMU-132), participants must not have known active or chronic hepatitis B virus (HBV) infection, requiring suppressive therapy or known active hepatitis C virus (HCV) infection. Participants with a known history of HCV infection must have been treated and cured * Participants must not have received enzyme-inducing anti-epileptic agents (e.g., carbamazepine, phenytoin, phenobarbital, primidone) within 7 days prior to registration or within 14 days of planned start of cycle 1, day 1 treatment, and participants must not be planning to receive enzyme-inducing anti-epileptic agents (e.g., carbamazepine, phenytoin, phenobarbital, primidone) for the duration of protocol treatment * Participants must not be receiving warfarin (or other coumarin derivatives) at time of registration or be planning to receive warfarin (or other coumarin derivatives) for the duration of protocol treatment. Participants who are able to switch to low molecular weight heparin (LMWH) or direct oral anticoagulants (DOACs) prior to date of registration (and plan to remain off of warfarin or other coumarin derivatives) for the duration of protocol treatment) are eligible * Patients must not be receiving or be planning to receive concomitantly any other anti-cancer therapy, including endocrine therapy. Note: Concomitant hormone replacement therapy is allowed * Participants must not have a condition requiring ongoing systemic treatment with corticosteroids (\> 4 mg daily dexamethasone \[or bioequivalent\]) or other immunosuppressive medications within 7 days prior to the baseline MRI. Corticosteroids administration must be stable and planned to remain =\< 4 mg daily for the duration of protocol treatment. However, use of corticosteroids for clinical symptoms is allowed based upon treating physician discretion * Participants must not have uncontrolled diabetes in the opinion of the treating investigator 21 days prior to registration * Participants must not be pregnant or nursing. Women of reproductive potential must have a negative serum or urine pregnancy test within 7 days prior to registration. Women and men of reproductive potential must have agreed to use an effective contraceptive method for the duration of protocol treatment and for at least 6 months after the last dose of sacituzumab govitecan (IMMU-132). A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined, he/she is responsible for beginning contraceptive measures

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Conditions

The condition(s) this trial relates to.

brain cancer breast cancer Her2-receptor negative breast cancer invasive breast carcinoma metastatic malignant neoplasm in the brain metastatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anatomic stage IV breast cancer ajcc V8 Invasive breast carcinoma Metastatic HER2-negative breast carcinoma Metastatic malignant neoplasm in the brain Prognostic stage IV breast cancer ajcc V8

Contacts and locations

Locations

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States
Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States
Alegent Health Mercy Hospital

Council Bluffs, Iowa, 51503, United States
Alta Bates Summit Medical Center - Summit Campus

Oakland, California, 94609, United States
Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States
Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States
Armes Family Cancer Center

Findlay, Ohio, 45840, United States
Ascension Providence Hospitals - Novi

Novi, Michigan, 48374, United States
Ascension Providence Hospitals - Southfield

Southfield, Michigan, 48075, United States
Ascension Via Christi - Pittsburg

Pittsburg, Kansas, 66762, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Baptist Cancer Center-Grenada

Grenada, Mississippi, 38901, United States
Baptist Memorial Hospital and Cancer Center-Collierville

Collierville, Tennessee, 38017, United States
Baptist Memorial Hospital and Cancer Center-Desoto

Southhaven, Mississippi, 38671, United States
Baptist Memorial Hospital and Cancer Center-Golden Triangle

Columbus, Mississippi, 39705, United States
Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, Tennessee, 38120, United States
Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, Mississippi, 38655, United States
Bay Area Breast Surgeons Inc

Emeryville, California, 94608, United States
Bay Area Hospital

Coos Bay, Oregon, 97420, United States
Bay Area Tumor Institute

Oakland, California, 94609, United States
Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Bethesda North Hospital

Cincinnati, Ohio, 45242, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Billings Clinic-Cody

Cody, Wyoming, 82414, United States
Boulder Community Foothills Hospital

Boulder, Colorado, 80303, United States
Bozeman Deaconess Hospital

Bozeman, Montana, 59715, United States
Broadlawns Medical Center

Des Moines, Iowa, 50314, United States
CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States
CHI Health Saint Francis

Grand Island, Nebraska, 68803, United States
CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, 71913, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004, United States
Capital Region Southwest Campus

Jefferson City, Missouri, 65109, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle on Vermilion

Danville, Illinois, 61832, United States
Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States
Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States
Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Cheyenne Regional Medical Center-West

Cheyenne, Wyoming, 82001, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Cleveland Clinic Cancer Center Mansfield

Mansfield, Ohio, 44906, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Commonwealth Cancer Center-Corbin

Corbin, Kentucky, 40701, United States
Community Hospital of Anaconda

Anaconda, Montana, 59711, United States
Community Medical Hospital

Missoula, Montana, 59804, United States
Contra Costa Regional Medical Center

Martinez, California, 94553-3156, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Creighton University Medical Center

Omaha, Nebraska, 68131, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dayton Physician LLC-Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States
Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401, United States
Epic Care Cyberknife Center

Walnut Creek, California, 94597, United States
Epic Care Partners in Cancer Care

Emeryville, California, 94608, United States
Epic Care-Dublin

Dublin, California, 94568, United States
Fairbanks Memorial Hospital

Fairbanks, Alaska, 99701, United States
Flaget Memorial Hospital

Bardstown, Kentucky, 40004, United States
Franciscan Research Center-Northwest Medical Plaza

Tacoma, Washington, 98405, United States
Freeman Health System

Joplin, Missouri, 64804, United States
Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341, United States
Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States
Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States
Good Samaritan Hospital Medical Center

West Islip, New York, 11795, United States
Good Samaritan Regional Health Center

Mount Vernon, Illinois, 62864, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States
Greater Regional Medical Center

Creston, Iowa, 50801, United States
Harrison HealthPartners Hematology and Oncology-Bremerton

Bremerton, Washington, 98310, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States
Harrison Medical Center

Bremerton, Washington, 98310, United States
HaysMed University of Kansas Health System

Hays, Kansas, 67601, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States
Hickman Cancer Center

Adrian, Michigan, 49221, United States
Highline Medical Center-Main Campus

Burien, Washington, 98166, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States
Illinois CancerCare - Washington

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Jefferson Healthcare

Port Townsend, Washington, 98368, United States
Jewish Hospital

Louisville, Kentucky, 40202, United States
Jewish Hospital Medical Center South

Shepherdsville, Kentucky, 40165, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kalispell Regional Medical Center

Kalispell, Montana, 59901, United States
Katmai Oncology Group

Anchorage, Alaska, 99508, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Kootenai Cancer Clinic

Sandpoint, Idaho, 83864, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Littleton Adventist Hospital

Littleton, Colorado, 80122, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
MGC Hematology Oncology-Union

Union, South Carolina, 29379, United States
Mary Greeley Medical Center

Ames, Iowa, 50010, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McFarland Clinic PC - Ames

Ames, Iowa, 50010, United States
McFarland Clinic PC-Boone

Boone, Iowa, 50036, United States
McFarland Clinic PC-Jefferson

Jefferson, Iowa, 50129, United States
McFarland Clinic PC-Marshalltown

Marshalltown, Iowa, 50158, United States
McFarland Clinic PC-Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States
McKee Medical Center

Loveland, Colorado, 80539, United States
Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa, 50314, United States
Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, 50325, United States
Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States
Memorial Medical Center

Springfield, Illinois, 62781, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin

Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital South

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Hospital Washington

Washington, Missouri, 63090, United States
Mercy Medical Center

Durango, Colorado, 81301, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Methodist West Hospital

West Des Moines, Iowa, 50266-7700, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Miami Valley Hospital South

Centerville, Ohio, 45459, United States
Midlands Community Hospital

Papillion, Nebraska, 68046, United States
Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, 93420, United States
Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, 93444, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Outpatient Center-Sunset Hills

Sunset Hills, Missouri, 63127, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Mountain Blue Cancer Care Center - Swedish

Englewood, Colorado, 80113, United States
North Coast Cancer Care

Sandusky, Ohio, 44870, United States
North Colorado Medical Center

Greeley, Colorado, 80631, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
Northwest Medical Specialties PLLC

Tacoma, Washington, 98405, United States
Northwestern University

Chicago, Illinois, 60611, United States
Olathe Health Cancer Center

Olathe, Kansas, 66061, United States
Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401, United States
Pacific Gynecology Specialists

Seattle, Washington, 98104, United States
Parker Adventist Hospital

Parker, Colorado, 80138, United States
Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Regional Cancer Partnership

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States
Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Reid Health

Richmond, Indiana, 47374, United States
Rocky Mountain Cancer Centers - Centennial

Centennial, Colorado, 80112, United States
Rocky Mountain Cancer Centers - Swedish

Englewood, Colorado, 80113, United States
Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304, United States
Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120, United States
Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado, 80501, United States
Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, 80218, United States
Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States
Rocky Mountain Cancer Centers-Rose

Denver, Colorado, 80220, United States
Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, 80124, United States
Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260, United States
Rose Medical Center

Denver, Colorado, 80220, United States
Rush - Copley Medical Center

Aurora, Illinois, 60504, United States
Rush-Copley Healthcare Center

Yorkville, Illinois, 60560, United States
SIH Cancer Institute

Carterville, Illinois, 62918, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Medical Center-Baker City

Baker City, Oregon, 97814, United States
Saint Alphonsus Medical Center-Nampa

Nampa, Idaho, 83686, United States
Saint Alphonsus Medical Center-Ontario

Ontario, Oregon, 97914, United States
Saint Anthony Hospital

Lakewood, Colorado, 80228, United States
Saint Anthony Regional Hospital

Carroll, Iowa, 51401, United States
Saint Anthony's Health

Alton, Illinois, 62002, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Charles Health System-Redmond

Redmond, Oregon, 97756, United States
Saint Clare Hospital

Lakewood, Washington, 98499, United States
Saint Elizabeth Hospital

Enumclaw, Washington, 98022, United States
Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, 68510, United States
Saint Francis Hospital

Federal Way, Washington, 98003, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint John's Cancer Institute

Santa Monica, California, 90404, United States
Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States
Saint Joseph London

London, Kentucky, 40741, United States
Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States
Saint Joseph Regional Cancer Center

Bryan, Texas, 77802, United States
Saint Louis Cancer and Breast Institute-Ballwin

Ballwin, Missouri, 63011, United States
Saint Louis Cancer and Breast Institute-South City

St Louis, Missouri, 63109, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83686, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
Saints Mary and Elizabeth Hospital

Louisville, Kentucky, 40215, United States
Salina Regional Health Center

Salina, Kansas, 67401, United States
Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States
Solinsky Center for Cancer Care

Manchester, New Hampshire, 03103, United States
South Pointe Hospital

Warrensville Heights, Ohio, 44122, United States
Southeast Cancer Center

Cape Girardeau, Missouri, 63703, United States
Southeastern Medical Oncology Center-Clinton

Clinton, North Carolina, 28328, United States
Southeastern Medical Oncology Center-Goldsboro

Goldsboro, North Carolina, 27534, United States
Southeastern Medical Oncology Center-Jacksonville

Jacksonville, North Carolina, 28546, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Southwest Oncology PC

Durango, Colorado, 81301, United States
Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Springfield Regional Cancer Center

Springfield, Ohio, 45504, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122-4307, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
The Medical Center of Aurora

Aurora, Colorado, 80012, United States
The Melanoma and Skin Cancer Institute

Englewood, Colorado, 80113, United States
The Women's Imaging Center

Denver, Colorado, 80209, United States
Toledo Clinic Cancer Centers-Monroe

Monroe, Michigan, 48162, United States
Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, 43623, United States
TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, 45255, United States
TriHealth Cancer Institute-Westside

Cincinnati, Ohio, 45247, United States
Trinity Regional Medical Center

Fort Dodge, Iowa, 50501, United States
Truman Medical Centers

Kansas City, Missouri, 64108, United States
UC Irvine Health Cancer Center-Newport

Costa Mesa, California, 92627, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UPMC Camp Hill

Camp Hill, Pennsylvania, 17011, United States
UPMC Memorial

York, Pennsylvania, 17408, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109, United States
UPMC Susquehanna

Williamsport, Pennsylvania, 17701, United States
UPMC-Mercy Hospital

Pittsburgh, Pennsylvania, 15219, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona, 85704, United States
University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102, United States
University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States
Valley Radiation Oncology

Peru, Illinois, 61354, United States
Vanderbilt Breast Center at One Hundred Oaks

Nashville, Tennessee, 37204, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Vanderbilt-Ingram Cancer Center Cool Springs

Franklin, Tennessee, 37067, United States
Walter Knox Memorial Hospital

Emmett, Idaho, 83617, United States
Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600, United States
Welch Cancer Center

Sheridan, Wyoming, 82801, United States
Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States
Western Surgical Care

Denver, Colorado, 80220, United States

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