METASTATIC MALIGNANT NEOPLASM IN THE BRAIN

This study compares two radiation treatments for people with small cell lung cancer that has spread to the brain. One treatment uses precise, high-dose radiation only on the tumors, while the other treats the whole brain but avoids the memory center. The goal is to see which appr…

This study looks at two ways of giving focused radiation to people whose cancer has spread to the brain. One method gives all the radiation in a single session, while the other spreads it over several sessions. The goal is to see which approach better controls the tumors and caus…

This study tests a combination of two treatments for people with breast cancer that has spread to the brain. One is a vaccine made from the patient's own immune cells, designed to help the body recognize and attack cancer. The other is a drug called pembrolizumab, which helps the…

This study tests whether a combination of targeted drugs (encorafenib and binimetinib) plus an immunotherapy (nivolumab) works better than two immunotherapies (ipilimumab and nivolumab) for people with BRAF-V600 mutant melanoma that has spread to the brain. About 112 adults with …

This study looks at whether giving focused radiation before or after surgery works better for people with cancer that has spread to the brain. About 140 adults who need surgery for a brain tumor will be randomly assigned to receive stereotactic radiosurgery either before or after…

This study tests whether giving focused radiation before surgery is better than after surgery for people whose cancer has spread to the brain. About 180 adults with brain metastases will be randomly assigned to one of the two timing groups. The goal is to see which approach reduc…

This study tests a new treatment for advanced melanoma that has spread to the brain. It combines chemotherapy (temozolomide) with specially grown immune cells from a healthy donor (called NK cells). The goal is to see if this combination is safe and can shrink brain tumors. About…

This study is testing a special PET/MRI scan that uses a radioactive tracer to find HER2-positive breast cancer that has spread to the brain. The goal is to see if the scan can show which brain tumors will respond to a standard chemotherapy drug. About 10 women with metastatic br…

This study tests whether using two different contrast agents (gadolinium and ferumoxytol) during an MRI can provide clearer images of brain abnormalities, such as tumors or nerve disorders. About 150 participants with neurological symptoms or brain findings will undergo MRI scans…

This study tests two advanced MRI techniques to better tell apart brain tumors that have come back from tissue damage caused by radiation therapy. About 42 adults with brain metastases will be scanned before surgery or radiation. The goal is to help doctors choose the right treat…

This study compares two types of radiation therapy for people whose cancer has spread to the brain. One group gets a single high dose of radiation, while the other gets three smaller doses over several days. The goal is to see if the three-dose approach works better at controllin…

This study looks at people with HER2+ breast cancer that has spread. All are taking trastuzumab, a targeted therapy. The main goal is to track how often heart problems occur. A smaller part of the study tests if the heart drug carvedilol can prevent these side effects.

This study is testing a small device called a microdialysis catheter that is placed in the brain during surgery to collect fluid samples. The goal is to see if it is safe and can gather useful information (biomarkers) about brain tumors like glioblastoma and metastatic cancer. Ab…

This early-phase study tests a special PET scan that uses a radioactive tracer to find immune cells (CD8+ T-cells) inside brain tumors. About 20 adults with brain tumors scheduled for surgery will receive the tracer before their operation. The goal is to see if this imaging metho…

This study tests a new way to map important brain areas during tumor surgery. Researchers will use a special grid to record brain activity while patients move or speak. The goal is to see if this method helps surgeons avoid damaging areas that control movement and speech. About 7…

This early-phase trial studies how to best give arginine (a natural amino acid) alongside whole brain radiation for people whose cancer has spread to the brain. Researchers will compare oral and IV arginine to find the dose that reaches the highest blood levels. The goal is to le…

This study asks brain cancer patients about their experience with telemedicine (video or phone visits) compared to in-person visits. Researchers want to learn if patients feel they receive good care through telemedicine. The goal is to help doctors improve how they deliver care r…