ANATOMIC STAGE III BREAST CANCER AJCC V8

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors. The goal is to see if the combination is safe and helps the immune system fight cancer more effectively. Ab…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control

Last updated Jun 23, 2026 12:09 UTC

Could a heart drug help immunotherapy fight breast cancer again?

This phase 2 trial tests whether adding the beta-blocker propranolol to the immunotherapy drug pembrolizumab can help shrink tumors in people with metastatic triple-negative breast cancer that has stopped responding to checkpoint inhibitors. About 37 adults with advanced, unresec…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: Emory University • Aim: Disease control

Last updated Jun 23, 2026 11:58 UTC

Custom-Made vaccine takes on Triple-Negative breast cancer

This early-phase trial is testing a personalized vaccine made from a patient's own tumor, given alone or with drugs that boost the immune system (pembrolizumab or ipilimumab). The goal is to see if the combination is safe and can help the immune system attack triple-negative brea…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: Emory University • Aim: Disease control

Last updated Jun 23, 2026 11:57 UTC

Can new drug combos outsmart PARP resistance in BRCA breast cancer?

This phase 2 trial tests whether adding cediranib or ceralasertib to olaparib can overcome resistance in BRCA-mutated advanced breast cancer. About 60 participants with HER2-negative, BRCA-positive tumors that have progressed on prior therapy will receive one of the two drug comb…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control

Last updated Jun 22, 2026 11:59 UTC

New hope for Hard-to-Treat cancers: drug targets DNA repair weakness

This phase 2 trial is testing the drug talazoparib in people with advanced solid tumors that have specific mutations in DNA repair genes. Talazoparib works by blocking a protein called PARP, which cancer cells use to fix their damaged DNA, leading to cancer cell death. The study …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 22, 2026 11:58 UTC

Experimental drug combo targets Hard-to-Treat HER2 cancers

This early-phase trial tests the safety and best dose of a new drug combination—pidnarulex plus trastuzumab deruxtecan—in people with advanced breast cancer and other solid tumors that have the HER2 protein. The study enrolls 36 adults whose cancer has spread or cannot be surgica…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 22, 2026 11:56 UTC

Vaccine boosts breast cancer fight before surgery

This study tests whether adding a vaccine called WOKVAC to standard chemotherapy and targeted therapy before surgery can help the immune system better attack HER2+ breast cancer. About 25 adults with early-stage breast cancer will receive the vaccine alongside their regular treat…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control

Last updated Jun 18, 2026 11:53 UTC

Shorter radiation before or after breast surgery may cut side effects

This study compares giving a shorter, higher-dose radiation treatment (hypofractionated radiotherapy) either before or after breast surgery in 120 adults with non-metastatic breast cancer. The goal is to see which timing causes fewer serious side effects and works better. Researc…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control

Last updated Jun 18, 2026 11:53 UTC

New hope for Hard-to-Treat breast cancer: early trial combines three drugs

This early-phase study tests a new drug, ASTX727, added to standard chemotherapy and immunotherapy for people with metastatic triple-negative breast cancer that cannot be removed by surgery. The goal is to find the safest dose and see if the combination can shrink tumors or keep …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 18, 2026 11:51 UTC

Breast cancer survivors: could a common diabetes drug lower your risk?

This study looks at whether metformin, a diabetes drug, can help prevent or reverse insulin resistance in women who finished chemotherapy for early-stage breast cancer. Insulin resistance raises the risk of diabetes and heart disease, and may also be linked to more aggressive bre…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: City of Hope Medical Center • Aim: Disease control

Last updated Jun 18, 2026 11:48 UTC

New study aims to help latina breast cancer survivors lose weight and improve survival

This study tests two remote weight loss programs designed for Latina breast cancer survivors. Being overweight can worsen breast cancer outcomes, and few programs exist for this group. The study will enroll 640 women who have had breast cancer to see which approach works best for…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control

Last updated Jun 17, 2026 12:06 UTC

New study tests cheaper drug to block estrogen in breast cancer

This study compares two drugs, leuprolide and goserelin, to see how well they lower estrogen levels in premenopausal women with breast cancer. Both drugs work by temporarily stopping the ovaries from making estrogen, which can fuel cancer growth. The trial will enroll 75 women an…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control

Last updated Jun 16, 2026 12:51 UTC

Immunotherapy boost may stop High-Risk breast cancer from returning

This study tests whether adding an immunotherapy drug (durvalumab) to standard chemotherapy can better prevent breast cancer from coming back in people with a high-risk type of hormone receptor-positive, HER2-negative breast cancer. About 3,680 adults with stage II or III breast …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 16, 2026 12:48 UTC

5-Day breast radiation: a game changer for cancer patients?

This study tests a new, ultra-short radiation schedule for women with stage I-III breast cancer who have had a lumpectomy. Instead of weeks of daily radiation, the whole breast and surgical cavity are treated together over just 5 days. The goal is to see if this approach controls…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control

Last updated Jun 15, 2026 19:02 UTC

New combo therapy offers hope for Hard-to-Treat breast cancer

This study tests whether combining tamoxifen (a hormone blocker) with a targeted form of chemotherapy (liposomal doxorubicin) can shrink tumors in people with advanced triple-negative breast cancer that has spread or cannot be removed by surgery. The trial enrolls 30 adults who h…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control

Last updated Jun 15, 2026 18:56 UTC

New triple-drug attack shows promise against hard-to-treat breast cancer

This early-phase trial tests whether adding an experimental drug (ZEN003694) to standard immunotherapy (pembrolizumab) and chemotherapy (nab-paclitaxel) is safe and tolerable for people with advanced triple-negative breast cancer that has spread. About 57 participants will receiv…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 15, 2026 18:55 UTC

Electric field device joins forces with cancer drugs in early trial

This early-phase study tests a wearable device that creates electric fields (tumor treating fields) combined with either cabozantinib or a chemo-immunotherapy pair (nab-paclitaxel and atezolizumab) in people with advanced solid tumors in the abdomen or chest. The goal is to find …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control

Last updated Jun 12, 2026 12:08 UTC

Could less chemo be better for older breast cancer patients?

This study looks at whether giving a lower dose of two chemotherapy drugs (docetaxel and cyclophosphamide) can work well and cause fewer side effects in women aged 65 and older with early-stage HER2-negative breast cancer. The goal is to help these women complete their treatment …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control

Last updated Jun 12, 2026 12:08 UTC

New drug combo shows promise for Hard-to-Treat cancers

Prevention Recruiting now

This early-phase study tests the safety and best dose of two drugs, ZEN003694 and abemaciclib, given together. It is for people with advanced breast cancer, NUT carcinoma, or other solid tumors that have spread or cannot be removed by surgery. The goal is to see if the combinatio…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 05, 2026 12:06 UTC

New ultrasound technique may predict chemo success early in breast cancer

Diagnosis Recruiting now

This study tests whether a special type of ultrasound, using a contrast dye called Definity, can measure pressure inside breast tumors to predict how well chemotherapy is working. About 200 women with locally advanced breast cancer will get three of these ultrasounds before and d…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2, PHASE3 • Sponsor: Kibo Nam • Aim: Diagnosis

Last updated May 29, 2026 14:18 UTC

New procedure aims to stop arm swelling before it starts

This study tests whether doing a lymphovenous bypass during lymph node surgery can prevent lymphedema (arm swelling) in people with breast cancer or melanoma. The bypass creates a new path for fluid to drain away from the arm. Researchers will compare swelling rates in 252 partic…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Prevention

Last updated Jun 17, 2026 12:05 UTC

Tailored exercise may protect heart and fitness in breast cancer patients on chemo

This study tests whether a personalized virtual exercise program, combined with health education, helps breast cancer patients maintain their ability to exercise, heart health, and quality of life during chemotherapy. About 120 adults with stage I-III breast cancer scheduled for …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: Wake Forest University Health Sciences • Aim: Symptom relief

Last updated Jun 17, 2026 12:04 UTC

Can a baldness drug save hair during breast cancer treatment?

This study looks at whether minoxidil (a hair growth drug) can help with hair loss caused by hormone therapy in breast cancer patients. About 50 women with stage I-IV breast cancer who are on hormone therapy and have noticed hair thinning will either take minoxidil pills or apply…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: EARLY_PHASE1 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief

Last updated Jun 16, 2026 12:55 UTC

Brain food: MIND diet may fight chemo fog in breast cancer patients

This study tests whether a 12-week MIND eating plan can reduce memory problems, fatigue, and other symptoms in women with stage II-III triple-negative breast cancer during chemotherapy. About 60 women will be randomly assigned to either the MIND diet or general health coaching, w…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief

Last updated Jun 15, 2026 19:05 UTC

Acupuncture may help black women avoid debilitating joint pain during breast cancer treatment

This study tests whether in-person acupuncture or virtual acupressure can prevent joint pain caused by aromatase inhibitors, a common hormone therapy for breast cancer. It focuses on Non-Hispanic Black women with early-stage breast cancer, who are more likely to stop treatment du…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: Emory University • Aim: Symptom relief

Last updated Jun 15, 2026 19:02 UTC

Laser therapy offers hope for breast cancer survivors suffering from vaginal dryness

This study tests a laser treatment for vaginal dryness in breast cancer survivors. Many survivors experience this side effect from cancer treatments like chemotherapy or hormone therapy. The trial will compare the laser to no treatment in 250 women to see if it improves symptoms.

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Symptom relief

Last updated Jun 15, 2026 18:57 UTC

Potato starch may ease joint pain in breast cancer patients

This study tests whether a dietary supplement called resistant potato starch can help prevent joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. About 20 people with stage 0-III breast cancer or at high risk for it will take the supplement …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Symptom relief

Last updated Jun 12, 2026 12:07 UTC

Stress relief trial aims to ease triple negative breast cancer journey

This study tests whether a 10-week stress reduction program is practical and helpful for women with early-stage triple negative breast cancer. The program teaches relaxation, coping skills, and communication, and also connects participants with social services for needs like tran…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief

Last updated Jun 03, 2026 12:04 UTC

Friends and fitness: key to life after cancer?

This study follows 250 young adult cancer survivors to see how their social relationships and physical activity change over time and how these factors affect their quality of life. Participants wear an activity tracker and complete surveys. The goal is to learn how to better supp…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Sponsor: University of Southern California • Aim: Knowledge-focused

Last updated Jun 23, 2026 18:12 UTC

New tool aims to help breast cancer patients decide on preventive surgery

This study tests a decision-making tool for women newly diagnosed with breast cancer who are considering whether to have the healthy breast removed preventively (contralateral prophylactic mastectomy). The tool is designed to provide clear, balanced information. Researchers will …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused

Last updated Jun 23, 2026 11:59 UTC

Breast cancer drug's skin side effects under the microscope

This study looks at how aromatase inhibitor therapy changes skin quality and self-esteem in breast cancer survivors. Researchers will use skin imaging and surveys to track changes in 35 women starting this hormone therapy. The goal is to better understand and manage these side ef…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Sponsor: Mayo Clinic • Aim: Knowledge-focused

Last updated Jun 23, 2026 11:59 UTC

Mayo clinic study probes immune secrets of breast cancer drugs

This study collects blood and tumor samples from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. Researchers want to see how the immune system reacts to these treatments. The goal is to learn more, not to test a new the…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Sponsor: Mayo Clinic • Aim: Knowledge-focused

Last updated Jun 22, 2026 12:09 UTC

Gene-Guided cancer therapy: a new hope for advanced tumors

This study screens patients with advanced solid tumors to find genetic changes in their cancer cells. Based on those results, participants may be matched to a treatment trial that targets their specific mutation. The goal is to improve tumor control and help doctors plan better c…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused

Last updated Jun 18, 2026 11:47 UTC

Breast cancer survivors needed for biobank study

This study collects blood samples and health information from 1,300 women who have had stage I-III breast cancer and finished active treatment. The goal is to create a biorepository that scientists can use in the future to explore links between genes, molecules, and long-term can…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Sponsor: University of Southern California • Aim: Knowledge-focused

Last updated Jun 16, 2026 12:50 UTC

Can a PET scan predict which breast cancer patients will respond to treatment?

This study tests whether a special type of PET scan (FFNP-PET/CT) can predict how well a drug combination (abemaciclib plus hormone therapy) works in people with advanced hormone receptor-positive, HER2-negative breast cancer. About 60 participants with metastatic or locally adva…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: University of Washington • Aim: Knowledge-focused

Last updated Jun 15, 2026 19:09 UTC

Breast cancer and sleepless nights: new study investigates the link

This study looks at how sleep changes in women with early-stage breast cancer during treatment. Researchers will track sleep patterns and check for links to stress, social support, and living environment. About 100 participants will wear a sleep monitor and answer surveys before,…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused

Last updated Jun 11, 2026 12:12 UTC

Blood test may spot breast cancer resistance before It's too late

This study is looking at whether a blood test called DiviTum TKa can predict when hormone-receptor-positive, HER2-negative metastatic breast cancer stops responding to treatment. About 100 participants will give blood samples before and during their standard therapy. The goal is …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Sponsor: Mayo Clinic • Aim: Knowledge-focused

Last updated Jun 10, 2026 13:25 UTC

New ultrasound marker aims to improve breast cancer surgery guidance