ANATOMIC STAGE III BREAST CANCER AJCC V8

This phase II trial at Mayo Clinic tests whether estradiol, a form of estrogen, can help patients with a specific subtype of triple negative breast cancer that has a receptor called ER beta. The study enrolls 8 women with advanced or metastatic disease. Researchers will measure h…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control

Last updated Jun 23, 2026 12:01 UTC

New drug cocktail shows promise in early cancer trial

This phase 1 trial is testing the safety and best dose of a combination of three drugs—entinostat, nivolumab, and ipilimumab—in people with advanced solid tumors that have spread or cannot be removed. The goal is to see if this mix can help the immune system fight cancer more eff…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 23, 2026 11:55 UTC

Experimental drug combo targets Hard-to-Treat cancers

This early-phase trial tests an experimental drug called BAY 1895344 combined with standard chemotherapy (cisplatin, with or without gemcitabine) in people with advanced solid tumors, especially urothelial cancer. The goal is to find the best dose and see how safe the combination…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 23, 2026 11:55 UTC

Double-Drug attack aims to stop HER2+ breast cancer relapse

This phase 3 trial tests whether adding tucatinib to standard T-DM1 therapy works better than T-DM1 alone at preventing breast cancer from coming back. About 1,056 patients with HER2-positive breast cancer who still have cancer cells after initial treatment will take part. The st…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control

Last updated Jun 22, 2026 12:00 UTC

New combo targets tough breast cancer: could it be a game changer?

This phase II trial tests whether adding an immunotherapy drug (atezolizumab) to a targeted therapy (olaparib) works better than olaparib alone for advanced non-HER2-positive breast cancer that has a BRCA mutation. About 81 patients with locally advanced or metastatic disease are…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 22, 2026 11:59 UTC

New drug cocktail targets Hard-to-Treat HER2 cancers

This early-phase trial is testing whether combining the targeted drug trastuzumab deruxtecan (DS-8201a) with an experimental pill called ceralasertib can safely treat advanced solid tumors that have a HER2 mutation. The study has two parts: first, finding the safest dose in 51 pa…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 22, 2026 11:56 UTC

New drug cocktail shows promise against tough breast cancer

This study tests a combination of two drugs, eribulin and copanlisib, in people with metastatic triple-negative breast cancer that has spread or cannot be removed. The goal is to find the safest dose and see if the combo can slow tumor growth better than eribulin alone. About 24 …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 18, 2026 11:52 UTC

New combo therapy shows promise for HIV patients with advanced cancer

This early-phase trial tested the safety of combining two drugs, nivolumab and cabozantinib, in 8 people with HIV who also have advanced solid tumors. The goal was to see if the combination is safe and can shrink or stabilize the cancer. The study focused on finding the right dos…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 16, 2026 12:53 UTC

New drug combo targets BRCA cancers in early trial

This early-phase study tests a combination of two drugs, niraparib and dostarlimab, in 18 adults with BRCA-mutated breast, pancreas, or ovary cancer that has spread or cannot be surgically removed. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: University of Washington • Aim: Disease control

Last updated Jun 16, 2026 12:51 UTC

New drug combo shows promise in slowing advanced breast cancer

This study tested whether adding the drug entinostat to standard hormone therapy (exemestane) helps people with advanced hormone receptor-positive breast cancer live longer without their cancer growing. About 600 adults with breast cancer that had spread or come back took part. T…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 15, 2026 19:02 UTC

New targeted therapy combo shows promise for HER2+ breast cancer

This study tests a combination of targeted drugs (ribociclib, tucatinib, trastuzumab, with or without fulvestrant) for HER2-positive breast cancer. In the first part, it looks at safety in patients whose cancer has spread. In the second part, it compares these drugs to standard c…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1, PHASE2 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control

Last updated Jun 15, 2026 18:56 UTC

Proton vs X-Ray: which radiation causes fewer side effects in breast cancer?

This study compares two types of radiation therapy—standard x-ray and proton beam—for people with breast cancer who have had surgery. The goal is to see which method causes fewer serious side effects or unplanned surgeries over two years. About 146 adults with stage I to III brea…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: Mayo Clinic • Aim: Disease control

Last updated Jun 15, 2026 18:55 UTC

New drug combo shows promise for resistant breast cancer

This study tests a new drug (TVB-2640) combined with standard treatments for people with HER2+ breast cancer that has spread and stopped responding to the usual therapy. The goal is to see if the combination can shrink or control the cancer. The trial involves 17 adults with adva…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control

Last updated Jun 12, 2026 12:08 UTC

Texts and calls boost breast cancer Pill-Taking in major trial

This study tests whether adding text message reminders and/or telephone counseling helps breast cancer patients take their daily hormone therapy pills more consistently. About 1,167 women with early-stage, hormone-sensitive breast cancer will be followed for up to two years. The …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control

Last updated Jun 12, 2026 12:04 UTC

PET scans may guide breast cancer treatment before surgery

Diagnosis Ongoing

This phase 2 trial tests whether a special PET/CT scan using a radioactive tracer (FDG) can predict how well HER2-positive breast cancer responds to standard chemotherapy before surgery. About 235 patients with stage II-III HER2+ breast cancer will get the scan early in treatment…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Diagnosis

Last updated Jun 23, 2026 11:57 UTC

New web tool aims to ease symptoms for young breast cancer survivors

This study tests a web-based portal called YES (Young, Empowered & Strong) designed to help adolescent and young adult breast cancer survivors monitor and manage their symptoms. Researchers will compare the quality of life of 400 women who use the portal to those receiving standa…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief

Last updated Jun 23, 2026 11:59 UTC

Writing away the pain: new study tests expressive writing for chinese breast cancer survivors

This study looks at whether a culturally tailored writing program can improve the well-being of Chinese immigrant women who had breast cancer (stages 0 to III). About 256 women who finished their main cancer treatment in the last 5 years will write about their experiences. The go…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief

Last updated Jun 22, 2026 12:05 UTC

Walking through chemo: new study tests exercise for older breast cancer patients

This study looks at whether a regular exercise program is practical for women aged 65 and older who are receiving chemotherapy for early-stage breast cancer. Participants will be asked to walk and do arm exercises several times a week. The goal is to see if exercise can reduce th…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief

Last updated Jun 17, 2026 12:07 UTC

New study aims to keep young breast cancer patients on lifesaving pills

This study tests whether regularly checking in on symptoms, along with providing educational materials, helps young women with early-stage breast cancer continue taking their hormone therapy as prescribed. Hormone therapy can cause unpleasant side effects, leading some to stop ea…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: SWOG Cancer Research Network • Aim: Symptom relief

Last updated Jun 15, 2026 19:06 UTC

New program aims to boost quality of life for seniors after breast cancer

This study tests a special check-up and support program for adults 65 and older who have finished treatment for early-stage breast cancer. The goal is to improve their overall health and quality of life by addressing physical, mental, and emotional needs. Participants will comple…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief

Last updated Jun 15, 2026 19:03 UTC

Can a digital kitchen program help breast cancer survivors eat healthier?

This study tests a remote program that combines mindfulness with nutrition and cooking lessons to help breast cancer survivors eat better. About 49 people who had stage I-III breast cancer in the past 5 years will take part. The program is delivered online through the Cook for Yo…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: Fred Hutchinson Cancer Center • Aim: Symptom relief

Last updated Jun 12, 2026 12:07 UTC

Can yoga and nutrition help breast cancer survivors feel better? a new study aims to find out.

This study looks at whether two different health programs are practical and liked by breast cancer survivors. About 106 people who finished treatment for early-stage breast cancer will try either an Ayurveda program (with diet, yoga, and touch therapy) or a self-guided online edu…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: University of California, San Francisco • Aim: Symptom relief

Last updated Jun 12, 2026 12:07 UTC

Virtual program aimed to ease cancer fear, but trial was withdrawn

This trial was designed to test whether an online mental health program could help women with advanced gynecologic or breast cancer manage their fear of the cancer coming back or getting worse. The study planned to compare the virtual program to standard educational materials. Ho…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused

Last updated Jun 23, 2026 12:09 UTC

New study tracks shoulder pain after breast cancer radiation

This study looks at shoulder and arm problems in breast cancer patients with lymph node involvement who receive radiation therapy. About 61 participants will be followed for one year after treatment to see how often they have lasting shoulder issues. The goal is to understand whi…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused

Last updated Jun 22, 2026 12:08 UTC

Cancer survivors share fertility hopes in new survey

This study surveys women aged 18-45 who have had gynecological or breast cancer to learn how they think about having a baby after cancer. Researchers will use the results to help future patients make informed decisions about treatment and family planning. About 1,410 participants…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused

Last updated Jun 22, 2026 12:06 UTC

Wheat germ supplement studied for immune boost in advanced cancer

This study looks at whether a fermented wheat germ supplement can help the immune system fight cancer better when taken with standard immunotherapy drugs. About 100 adults with advanced solid tumors (like lung, colon, or melanoma) will take the supplement alongside their usual tr…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE1 • Sponsor: University of California, Davis • Aim: Knowledge-focused

Last updated Jun 22, 2026 12:04 UTC

Can we predict who will get nerve damage from chemo?

This study aims to find out why some cancer patients develop nerve damage (tingling or numbness in hands and feet) from taxane chemotherapy. Researchers will track over 1,300 people with breast, lung, or ovarian cancer to see how age, gender, and other factors affect their risk. …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Sponsor: SWOG Cancer Research Network • Aim: Knowledge-focused

Last updated Jun 18, 2026 11:53 UTC

New ultrasound marker could help surgeons find cancer in lymph nodes

This early-stage study tests a new type of marker that can be seen more clearly on ultrasound. It is placed in lymph nodes where breast cancer has spread. The goal is to see if the marker is safe, stays in place, and helps surgeons find the cancer during surgery. About 15 people …

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Sponsor: Mayo Clinic • Aim: Knowledge-focused

Last updated Jun 18, 2026 11:52 UTC

Genetic test may predict who gets nerve pain from breast cancer chemo

This study looks at whether certain genes make African American women with breast cancer more likely to develop nerve damage (pain, numbness, tingling) from common chemotherapy drugs called taxanes. About 249 women with stage I-III breast cancer will receive either docetaxel or w…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Knowledge-focused

Last updated Jun 18, 2026 11:49 UTC

New study aims to help older breast cancer patients make chemotherapy choices

This study looks at how women aged 65 and older with early-stage breast cancer decide whether to have chemotherapy before or after surgery. Researchers will use surveys to understand their needs and then create a tool to help patients and doctors make better, shared decisions. Th…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused

Last updated Jun 18, 2026 11:49 UTC

Blood test may reveal hidden cancer after breast cancer surgery

This study looks at whether a blood test that finds tiny pieces of tumor DNA (called ctDNA) can detect leftover cancer cells in people with early-stage breast cancer. About 350 patients with stage I to III breast cancer will give blood samples before and after standard treatment.…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Phase: NA • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused

Last updated Jun 18, 2026 11:46 UTC

Massive biobank aims to unlock Cancer's secrets

This study collects tissue and blood samples from 1,600 people with various advanced cancers, along with their medical information, over the course of their treatment. Researchers will store these samples and data in a biobank for current and future studies. The goal is to better…

Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8

Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused

Last updated Jun 17, 2026 12:07 UTC

Gene test may guide breast cancer therapy choices