ANATOMIC STAGE III BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE III BREAST CANCER AJCC V8 explained in plain language.
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New hope for drug-resistant breast cancer: experimental combo shows promise
Disease control OngoingThis study tests a new drug (TVB-2640) combined with standard therapies in people with HER2-positive breast cancer that has spread and stopped responding to trastuzumab. The goal is to see if the combination can shrink or control tumors. About 17 adults with advanced breast cance…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 01, 2026 15:25 UTC
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New drug duo targets BRCA cancers in early trial
Disease control OngoingThis early-phase trial tests a combination of two drugs—niraparib and dostarlimab—in people with breast, pancreas, or ovarian cancers that have a BRCA gene mutation and have spread or can't be removed by surgery. Niraparib blocks a DNA repair process that cancer cells rely on, wh…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Washington • Aim: Disease control
Last updated Apr 30, 2026 15:52 UTC
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New drug combo shows promise in Tough-to-Treat cancers
Disease control OngoingThis early-phase study tests a new drug (BAY 1895344) combined with standard chemotherapy in people with advanced solid tumors, especially bladder cancer. The goal is to find the best dose and see if the combination is safe and tolerable. About 74 participants will receive the dr…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 30, 2026 15:51 UTC
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New 'Twinkling' marker may help surgeons spot cancer in lymph nodes
Disease control TerminatedThis early-stage study tests a special marker that shows up brightly on ultrasound, making it easier for surgeons to find and remove cancerous lymph nodes during breast cancer surgery. The study involves 15 adults with breast cancer that has spread to nearby lymph nodes. Research…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Disease control
Last updated Apr 30, 2026 15:48 UTC
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New drug combo shows promise in slowing advanced breast cancer
Disease control OngoingThis phase 3 trial tested whether adding the drug entinostat to standard hormone therapy (exemestane) helps people with advanced hormone receptor-positive breast cancer live longer without their cancer getting worse. The study included 608 adults whose breast cancer had spread or…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 29, 2026 15:03 UTC
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New triple therapy shows promise in Hard-to-Treat cancers
Disease control OngoingThis early-phase study tests the safety and best dose of a three-drug combination (entinostat, nivolumab, and ipilimumab) in people with advanced solid tumors or HER2-negative breast cancer that has spread or cannot be removed. The goal is to see if this approach can help control…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 29, 2026 15:01 UTC
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New web tool aims to ease life for young breast cancer survivors
Symptom relief OngoingThis study tests a web-based portal called YES that helps young breast cancer survivors (ages 15-39) track symptoms and find resources. About 400 women with early-stage breast cancer will use the portal or get standard care. The goal is to see if the portal improves quality of li…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated Apr 30, 2026 15:52 UTC
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Can a digital kitchen program help breast cancer survivors eat healthier?
Symptom relief OngoingThis study tests a program called MIND that delivers nutrition and cooking lessons online to breast cancer survivors. The goal is to see if it helps improve diet quality and increase fruit and vegetable intake. About 49 people with stage I-III breast cancer will participate, and …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Fred Hutchinson Cancer Center • Aim: Symptom relief
Last updated Apr 30, 2026 15:51 UTC
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Proton vs x-ray: which radiation is safer for breast cancer patients?
Symptom relief OngoingThis study compares standard X-ray radiation with newer proton beam radiation in women who have had surgery for breast cancer. The goal is to see which type causes fewer serious side effects or the need for additional surgeries. About 146 women with early to locally advanced brea…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Apr 30, 2026 15:51 UTC
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New study aims to keep young breast cancer patients on lifesaving pills
Symptom relief OngoingThis study tests whether regularly asking about symptoms, along with providing educational materials, helps young women (ages 18-50) with early-stage hormone-positive breast cancer stay on their prescribed hormone therapy. About 565 participants will either get symptom check-ins …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: SWOG Cancer Research Network • Aim: Symptom relief
Last updated Apr 30, 2026 15:48 UTC
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Chatbot could be new ally for breast cancer survivors battling insomnia
Symptom relief OngoingThis study looks at whether a chatbot called Cecebot can help breast cancer survivors with insomnia sleep better. About 60 women with stage I-III breast cancer who have trouble sleeping will use the chatbot, which sends text messages with tips from cognitive behavioral therapy an…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: University of Washington • Aim: Symptom relief
Last updated Apr 29, 2026 15:15 UTC
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Walking through chemo: new study tests exercise in older breast cancer patients
Symptom relief OngoingThis study looks at whether a regular exercise program is practical for women aged 65 and older who are receiving chemotherapy for early-stage breast cancer. Participants will be asked to walk and do arm exercises several times a week during their treatment. The goal is to see if…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Apr 29, 2026 15:14 UTC
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Texts and talks boost breast cancer Pill-Taking
Symptom relief OngoingThis study tests whether text message reminders and telephone counseling can help women with hormone-positive breast cancer take their daily endocrine therapy pills more consistently. About 1,167 women will either get usual care or extra support through texts and motivational cal…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Symptom relief
Last updated Apr 29, 2026 15:01 UTC
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New study tracks shoulder pain after breast cancer radiation
Knowledge-focused OngoingThis study looks at shoulder and arm problems in people with lymph-node positive breast cancer who receive radiation therapy. It compares two types of radiation (IMRT and 3DCRT) to see which causes less shoulder stiffness or pain. About 61 participants will fill out a questionnai…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated May 01, 2026 15:29 UTC
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Helping older breast cancer patients make chemo choices with confidence
Knowledge-focused OngoingThis study looks at how women aged 65 and older with early-stage breast cancer decide whether to have chemotherapy before or after surgery. Researchers will interview patients and doctors to understand what information they need. The goal is to create a tool that helps patients a…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 01, 2026 15:27 UTC
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Gene test may guide breast cancer therapy choices
Knowledge-focused OngoingThis study looks at whether a genetic test on tumor samples can predict if HER2-negative breast cancer will respond to chemotherapy or hormone therapy. About 1,100 people with early-stage breast cancer are taking part. The goal is to see if this testing can help doctors choose th…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Apr 30, 2026 15:52 UTC
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Cancer fear study pulled before starting
Knowledge-focused TerminatedThis study was designed to see if an online mental health program could help women with advanced gynecologic or breast cancer cope with the fear of their cancer coming back or getting worse. It planned to compare the program to standard educational materials. However, the study w…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated Apr 30, 2026 15:51 UTC
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Blood test may reveal hidden cancer after breast cancer surgery
Knowledge-focused TerminatedThis study looks at whether a blood test can find tiny traces of cancer DNA (called ctDNA) in people with early-stage breast cancer after standard treatment. The goal is to see if this test can help doctors decide who might need extra treatment. About 350 adults with stage I-III …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated Apr 30, 2026 15:49 UTC
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Gene test may predict chemo nerve pain in black breast cancer patients
Knowledge-focused OngoingThis study tests whether a genetic marker can identify African American women with breast cancer who are at higher risk for nerve damage from chemotherapy drugs like Taxol or Taxotere. About 249 women with stage I-III breast cancer will be followed to see how their genes affect n…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Knowledge-focused
Last updated Apr 29, 2026 15:02 UTC