AMPUTATION

This study tests a new surgical nerve interface (RPNI) in 3 people with above-knee amputation. The goal is to see if it can provide stable signals to control a motorized prosthetic leg and give sensory feedback. Participants will have surgery to implant the interface and electrod…

This study looks at whether microprocessor-controlled prosthetic knees (MPKs) — knees with a built-in computer — can reduce fall-related health problems in adults who use an above-knee artificial leg. About 100 participants who already use a standard non-computerized knee will be…

This study tests whether taking antibiotics by mouth for 6 weeks works as well as getting them through an IV for people with infected broken bones that didn't heal properly. About 250 adults will be randomly assigned to one of the two treatments, along with surgery. The goal is t…

This study compares two treatments for adults who have lost the tip of one finger: surgery or a special clear dressing that stays on for weeks. The goal is to see which approach leads to better hand function and less pain a year after the injury. About 252 participants will be ra…

This study tests a system called MyoTrain that helps people with arm amputations learn to control their prosthetic device through virtual exercises. Sixteen participants will be split into two groups: one using standard mental imagery training and the other using MyoTrain. The go…

This study is testing a new type of surgery for people who have had a leg amputated. The goal is to help them better control their residual limb, restore a sense of where the limb is in space (proprioception), and reverse muscle wasting. The study will enroll 26 adults who alread…

This study tests whether a hand transplant from a deceased donor can help people who have lost part or all of one or both hands and forearms regain better function, appearance, and feeling. Up to 100 adults aged 18 to 60 will receive the transplant and be followed with exams, X-r…

This study tests a new surgical method for arm amputations that may allow people to better control advanced prosthetic limbs and regain feeling in the missing limb. Researchers will perform the modified surgery on 10 participants and compare their results to 10 others who had sta…

This study tests a new device implanted under the skin that picks up muscle signals to control a robotic hand. Five adults with a hand or forearm amputation will have the device placed for up to one year. The goal is to see if it works better than current skin-stuck electrodes an…

This study tests a walking program on uneven surfaces for people with lower-leg prostheses. The goal is to help them walk more skillfully and confidently in daily life. Researchers are recruiting 35 adults who use a leg prosthesis regularly.

This study is testing whether adding a psychologist and a physical therapist to standard care helps people who need a leg amputation due to poor blood flow. About 40 adults will receive extra support before and after surgery. The goal is to see if this improves their mobility and…

This study compares two surgical techniques, TMR and RPNI, used alone or together, to reduce chronic and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned to one of three groups. The goal is to see which approach works best…

This study looks at whether a mobile workshop called Breizh Fabribus can help people with disabilities by making custom assistive devices on the spot using 3D printing and laser cutting. About 70 people who received a device will report how often they face their main activity lim…

This study tests whether injecting a person's own skin cells (from the palm) into the stump of a leg amputation can make the skin firmer and more comfortable for wearing a prosthetic. Twenty adults with below-knee amputations will receive either the cell injection or a placebo. T…

This study explores whether tiny electrical currents delivered to nerves in the leg can help people with below- or above-knee amputations feel their missing limb again. Participants may also get muscle implants to better control a robotic prosthetic leg. The goal is to improve wa…

This study is tracking how well freezing nerves during amputation surgery works to prevent pain after the operation and phantom limb pain. Researchers will watch 2000 adults who are having a limb removed to see if the procedure is safe and helpful. The goal is to find a better wa…

This study tests a new 3D-printed prosthetic foot that lets women veterans with below-knee amputations wear any shoe they choose. Many current artificial feet don't change shape, limiting footwear options and affecting body image and social life. About 18 women will try the new d…

This study tests whether artificial intelligence can improve walking stability in people who have had an above-knee amputation. Researchers will measure balance and stability in 40 participants as they train with AI-guided gait exercises. The goal is to see if AI can help make wa…

This study watches how people with a leg amputation adapt their walking to missing muscles and sensations. Researchers will measure movement and muscle activity in 75 participants while they walk on different surfaces. The goal is to understand these changes so future prosthetics…

This study looks at how the stiffness of a prosthetic foot affects people who have a leg amputation below the knee and use a bone-anchored limb or a standard socket. Researchers will measure bone stress, walking ability, pain, and fall risk as participants walk on different types…

This study compares powered and non-powered prosthetic knees in 26 adults with above-knee amputations who walk at a moderate level (K2). Participants will try each type of knee for three months while researchers track step counts, balance confidence, and well-being. The goal is t…

This study aims to understand how people with a leg amputation get around in their community, whether by walking with a prosthetic or using a wheelchair or scooter. Researchers will track 50 participants' movements using GPS and activity monitors for 10-21 days, along with questi…

This study aims to find the best way to set up sensors on a powered arm prosthesis for people with below-elbow amputations. Researchers will test different numbers and placements of sensors to see which helps users control the prosthetic hand best. Participants will try each setu…

This study is creating a large database of people who use a lower-limb prosthesis (artificial leg). Researchers will collect information on patient backgrounds, devices used, and long-term results from standard care. The goal is to better understand different patient groups and h…

This study aims to make powered prosthetic legs for above-knee amputees move more naturally by using machine learning. Researchers will collect data from people without amputations to create a computer model that helps the prosthetic leg adapt to different activities like walking…

This study aims to understand how our sense of touch works in healthy people, so that this knowledge can be used to create prosthetic limbs that provide realistic sensory feedback. Researchers will use a technique called microneurography to record nerve signals while participants…

This early study tests whether tiny electrode arrays implanted in the arm nerves of three amputees can record nerve signals and provide a sense of touch and position feedback for controlling a prosthetic hand. The goal is to see if the system can help users feel what they are tou…

This study looks at how people with arm amputations feel about two types of artificial hands: bionic and myoelectric. Researchers want to see if one type works better for daily tasks, how people feel about their body image, and how satisfied they are. The study will involve 20 ad…

This study aims to help veterans with below-knee amputations find the best prosthetic foot for stability and fall prevention. About 100 participants will try different prosthetic feet in the lab and at home to see which ones improve balance and confidence. The goal is to see if a…

This study compares two methods of controlling a prosthetic arm for adults with below-elbow limb loss. One method uses signals from two muscles, while the other uses signals from several muscles to better understand the user's intended movement. The goal is to see which method is…

This study looks at nerve pain in children and teens who had a limb removed before age 15-16. Researchers want to find out how common phantom or stump pain is and how it affects daily life and well-being. About 50 participants will fill out questionnaires during regular check-ups…