AMPUTATION
Clinical trials for AMPUTATION explained in plain language.
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Scientists test 'Bionic' legs that restore natural movement and feeling
Disease control CompletedThis study tested a new approach to help people with below-knee amputations control a prosthetic leg more naturally. It involved a special surgical technique that connects muscles in the residual limb, paired with a smart 'bionic' prosthesis. Researchers compared 14 people who ha…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Massachusetts Institute of Technology • Aim: Disease control
Last updated Apr 04, 2026 00:05 UTC
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Antibiotic tested in race to save diabetic Veterans' feet
Disease control CompletedThis study tested whether adding the antibiotic rifampin to standard antibiotic treatment could help prevent foot and leg amputations in diabetic patients with a serious bone infection called osteomyelitis. Over 800 veteran participants were randomly assigned to receive either ri…
Matched conditions: AMPUTATION
Phase: PHASE4 • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Apr 03, 2026 14:42 UTC
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New hands, new life: pioneering double transplant study shows brain can relearn
Disease control CompletedThis study tested whether transplanting two donor hands could restore function for people with double forearm amputations. Researchers followed 7 adult patients to see how their brains adapted to controlling the new hands. The goal was to offer an alternative to prosthetics by re…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Mar 31, 2026 12:10 UTC
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Surgery redesign aims to let amputees feel and control bionic limbs
Disease control CompletedThis study tested a new way to perform leg amputations. The goal was to create a better biological connection point in the remaining limb to allow for more intuitive control of advanced prosthetic legs. Researchers worked with 50 adults needing a leg amputation to see if this new…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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Stem cell shots aim to save limbs after amputation
Disease control CompletedThis early-stage study tested whether injecting donor stem cells into the leg muscles of patients about to have a major amputation could help prevent serious wound complications after surgery. The main goal was to check if the injections were safe. Researchers also wanted to see …
Matched conditions: AMPUTATION
Phase: PHASE1 • Sponsor: Indiana University • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New wound dressing could stop dangerous infections after amputation surgery
Prevention CompletedThis study tested whether a special vacuum-sealed dressing called PREVENA could prevent wound complications after leg amputation surgery. Researchers compared this dressing to standard wound care in 272 adults who had above- or below-knee amputations. They tracked whether the spe…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Thomas Jefferson University • Aim: Prevention
Last updated Mar 23, 2026 15:29 UTC
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Robotic knee tested to help amputees walk better
Symptom relief CompletedThis small study tested a new powered, computer-controlled knee prosthesis (the Mobili Knee) to see if it improved basic mobility and balance compared to people's usual prosthetic knees. Six adults with above-knee amputations performed walking and balance tests using both their r…
Matched conditions: AMPUTATION
Sponsor: Össur Iceland ehf • Aim: Symptom relief
Last updated Apr 04, 2026 00:06 UTC
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New adjustable sockets aim to improve life for amputees
Symptom relief CompletedThis study compared different types of prosthetic sockets for people with above-knee leg amputations. Researchers tested whether adjustable sockets were more comfortable and helped people move better than their standard, custom-made sockets. Twenty-nine participants tried their u…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: University of Michigan • Aim: Symptom relief
Last updated Apr 04, 2026 00:05 UTC
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Smart knee study aims to improve life for amputees
Symptom relief CompletedThis study tested a new computer-controlled prosthetic knee to see if it works better than existing smart knees. Fourteen people with above-knee amputations tried the new knee for three weeks and compared it to their usual device. Researchers measured how satisfied people felt wh…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Össur Iceland ehf • Aim: Symptom relief
Last updated Apr 01, 2026 14:40 UTC
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New Sweat-Blocking cloth could help amputees wear prosthetics more comfortably
Symptom relief CompletedThis study tested whether a medicated cloth (Qbrexza) could reduce excessive sweating where a prosthetic limb attaches. Thirteen people with limb amputations used either the active cloth or a placebo for four weeks, then switched, to see if it improved sweat control and how well …
Matched conditions: AMPUTATION
Phase: PHASE2 • Sponsor: University of Utah • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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Bionic leg tested to make walking easier for amputees
Symptom relief CompletedThis study tested a new, smart prosthetic leg for people with above- or below-knee amputations. The device uses sensors to read the user's muscle signals and has motorized knee and ankle joints that actively help with walking. Researchers checked if the advanced prosthesis was sa…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Fondazione Don Carlo Gnocchi Onlus • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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Smart knee aims to help amputees walk better
Symptom relief CompletedThis study tested a new computerized prosthetic knee to see if it improved daily life for people with leg amputations. Eleven participants used the new knee for four weeks at home. Researchers measured if it helped with walking, using stairs and ramps, and boosted confidence comp…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Össur Iceland ehf • Aim: Symptom relief
Last updated Mar 30, 2026 14:35 UTC
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Study aims to help amputee parents walk safer with kids
Symptom relief CompletedThis study tested different prosthetic feet to see which one helps people with below-knee amputations walk better while carrying heavy loads. Thirteen participants walked on a treadmill while carrying a weighted pack to simulate holding a child or a heavy bag. Researchers measure…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: VA Puget Sound Health Care System • Aim: Symptom relief
Last updated Mar 30, 2026 14:32 UTC
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New bionic foot aims for better step
Symptom relief CompletedThis small study tested a new, thinner prosthetic foot designed for people with below-knee amputations who have longer remaining limbs. The goal was to see if this new foot could store energy and provide a comfortable walking experience similar to bulkier prosthetics. Six partici…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Little Room Innovations, LLC • Aim: Symptom relief
Last updated Mar 30, 2026 14:29 UTC
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New 'Power Knee' aims to make walking easier for amputees
Symptom relief CompletedThis study tested a new powered prosthetic knee to see if it makes walking and daily activities easier for people with above-knee amputations. Seventeen participants tried the new 'Power Knee' and their own microprocessor-controlled knee in a crossover design. Researchers measure…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Össur Iceland ehf • Aim: Symptom relief
Last updated Mar 30, 2026 14:28 UTC
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Standing scan for better fit: new tech aims to ease amputee discomfort
Symptom relief CompletedThis study tested a new digital system for creating prosthetic sockets while the user is standing and bearing weight. It compared this new method to the traditional way of scanning a limb while sitting. The goal was to see if the new approach leads to a better-fitting, more comfo…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Indiana University • Aim: Symptom relief
Last updated Mar 09, 2026 14:25 UTC
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Scientists watch how amputees fight to stay upright
Knowledge-focused CompletedThis study aimed to understand how people with below-knee or above-knee amputations maintain their balance when the ground unexpectedly moves. Researchers observed 29 participants, including both amputees and healthy individuals, while they stood on a moving platform. They measur…
Matched conditions: AMPUTATION
Sponsor: Hacettepe University • Aim: Knowledge-focused
Last updated Apr 03, 2026 14:43 UTC
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Scientists measure how amputation affects core strength and balance
Knowledge-focused CompletedThis study aimed to understand how losing a lower leg affects core muscle function, endurance, balance, and walking. Researchers compared 26 adults with a below-knee amputation to adults without an amputation through a series of physical tests. The goal was to gather knowledge to…
Matched conditions: AMPUTATION
Sponsor: sevilay seda bas • Aim: Knowledge-focused
Last updated Apr 02, 2026 14:56 UTC
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Smart ankles put to the test: can High-Tech prosthetics prevent skin sores?
Knowledge-focused CompletedThis study aimed to understand how advanced, powered ankle prosthetics affect the pressure inside the socket and the health of the skin on the residual limb. Researchers measured six adults with below-knee amputations while they walked using different types of prosthetic ankles. …
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Prosthetists on the front lines: new study tests if they can catch hidden health risks after amputation
Knowledge-focused CompletedThis study tested whether having prosthetists screen for common hidden health problems during routine visits could improve care for people after a leg amputation. Seventy patients were randomly assigned to receive either standard care or standard care plus extra screenings for is…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: University of Delaware • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Scientists unlock the secret of why we swing our arms when we walk
Knowledge-focused CompletedThis study aimed to understand why people swing their arms while walking and how this movement is connected to balance and energy use. Researchers observed 25 people, including healthy individuals and those with conditions like stroke, Parkinson's, or multiple sclerosis, while th…
Matched conditions: AMPUTATION
Sponsor: Istituto Auxologico Italiano • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:31 UTC
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Can a cheaper prosthetic foot work as well as the standard?
Knowledge-focused CompletedThis study aimed to see if a new, lower-cost prosthetic foot works as well as the standard models for people with a below-knee amputation. Six participants performed walking, balance, and jumping tests indoors and outdoors while wearing each type of foot. The goal was to compare …
Matched conditions: AMPUTATION
Sponsor: The Hong Kong Polytechnic University • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:40 UTC
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New tool aims to predict who needs help at home after hospital
Knowledge-focused CompletedThis study tested a Turkish version of a questionnaire called the Johns Hopkins In-Room Independence Scale. Researchers gave the questionnaire to 100 adult volunteers with various conditions to see if it reliably measures how well a person can move and care for themselves in thei…
Matched conditions: AMPUTATION
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital • Aim: Knowledge-focused
Last updated Mar 25, 2026 14:08 UTC