AMPUTATION
Clinical trials for AMPUTATION explained in plain language.
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Magnetic beads in leg muscles could give amputees natural control of bionic limbs
Disease control OngoingThis study tests whether a magnetic bead tracking system, used together with a bone-anchored implant and a robotic ankle-foot prosthesis, can give people with below-knee amputation more natural control over their prosthetic limb. Up to 7 participants will receive the implants and…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated May 26, 2026 05:37 UTC
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New liners aim to stop prosthetic sweat problems
Symptom relief OngoingThis study compares three different prosthetic liners designed to reduce sweating in the residual limb of people with a below-knee amputation. The goal is to see if these liners improve how stable, secure, and comfortable the prosthesis feels. About 180 participants who already u…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: VA Puget Sound Health Care System • Aim: Symptom relief
Last updated May 26, 2026 05:40 UTC
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New smart liner and exercise combo aims to boost mobility for diabetic amputees
Symptom relief OngoingThis study tests a new digital prosthetic liner combined with an exercise program to improve comfort and mobility in people who lost a leg due to type 2 diabetes. About 38 participants will use the smart liner and exercise routine, and researchers will measure pressure on the lim…
Matched conditions: AMPUTATION
Phase: PHASE2 • Sponsor: Spaulding Rehabilitation Hospital • Aim: Symptom relief
Last updated May 26, 2026 05:38 UTC
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New exercise program aims to boost performance for amputee athletes
Knowledge-focused OngoingThis study looks at whether a specific type of exercise (PNF-based upper extremity strengthening plus core training) can improve physical fitness in amputee football players. Fourteen players with a leg amputation will be split into two groups: one gets the special exercises, the…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Uskudar University • Aim: Knowledge-focused
Last updated May 26, 2026 05:50 UTC
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Smart sensors aim to boost mobility for prosthesis users
Knowledge-focused OngoingThis study uses smartphone and wearable sensors to track how people with leg amputations use their prostheses at home and in the community. Researchers will analyze this data along with walking tests and interviews to create a toolbox that helps identify who needs more support an…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: Shirley Ryan AbilityLab • Aim: Knowledge-focused
Last updated May 26, 2026 05:48 UTC
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Ultrasound may give amputees better control over prosthetic arms
Knowledge-focused ENROLLING_BY_INVITATIONThis study aims to see if using ultrasound imaging to sense muscle activity can improve how people with upper limb amputations control their prosthetic arms. Researchers will compare this new method to standard myoelectric controls in 16 participants. The goal is to make prosthet…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: George Mason University • Aim: Knowledge-focused
Last updated May 26, 2026 05:48 UTC
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New study aims to prevent tissue damage in amputees with diabetes
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at how skin temperature changes in people who have a leg amputation and diabetes. Researchers want to understand what affects temperature and blood flow in the remaining leg and the other foot. They will also test if a special shock-absorbing prosthetic leg can h…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: University of Utah • Aim: Knowledge-focused
Last updated May 26, 2026 05:47 UTC
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New training aims to improve walking for amputees
Knowledge-focused OngoingThis study tests whether a 40-week limb-load biofeedback training program helps people with a leg prosthesis (osseointegrated) walk more symmetrically. About 15 participants will be split into two groups: one gets the training, the other gets standard care. Researchers will measu…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated May 26, 2026 05:47 UTC
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Spinal stimulation sensation study withdrawn before start
Knowledge-focused TerminatedThis study aimed to understand what sensations people feel when their spinal cord is electrically stimulated. It planned to recruit adults with spinal cord stimulators for pain management. However, the study was withdrawn before enrolling any participants.
Matched conditions: AMPUTATION
Sponsor: Lee Fisher, PhD • Aim: Knowledge-focused
Last updated May 22, 2026 13:55 UTC
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Numb prosthetics get a sensory upgrade – but study never started
Knowledge-focused TerminatedThis study aimed to help people with upper limb amputations feel their prosthetic hand as part of their own body by using nerve stimulation to recreate touch and position sense. Researchers planned to test different prosthetic types and measure how much users felt the device belo…
Matched conditions: AMPUTATION
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 22, 2026 13:54 UTC
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Amputation as last resort for chronic pain: what happens next?
Knowledge-focused OngoingThis study reviews the medical records of 20 adults who had a limb amputated to treat severe, long-lasting pain from complex regional pain syndrome (CRPS) after other treatments failed. Researchers want to learn how long it takes patients to get fitted with a functional artificia…
Matched conditions: AMPUTATION
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated May 19, 2026 12:00 UTC