Amputation

This study is testing whether a hand transplant from a deceased donor can help people who have lost part or all of one or both hands and forearms regain better function, appearance, and feeling. Participants will receive the transplant surgery and be followed closely with exams, …

This study tests a new system that uses magnetic beads implanted in leg muscles to help people with below-knee amputations control a bionic ankle-foot prosthesis. The beads track muscle movement in real time, sending signals to a robotic leg. Up to 7 participants will receive the…

This study looks at whether a specific type of exercise, called PNF-based upper extremity strengthening combined with core stabilization, can improve physical fitness in amputee football players. Fourteen players with a lower limb amputation will be split into two groups: one doi…

This trial tests whether adding a small device that provides touch and vibration feedback to prosthetic limbs can make them feel more natural and improve how well they work. Researchers will study adults with major limb amputations who use either advanced bionic or standard prost…

This trial tests whether a surgical technique called targeted muscle reinnervation (TMR) can reduce nerve pain and phantom limb pain after a leg amputation. TMR reroutes severed nerves to nearby muscle nerves to encourage organized regrowth. Adults scheduled for a below- or above…

This study tests a special nerve cap (Axoguard Large-Diameter Nerve Cap) in 15 adults who have had a limb injury or amputation. The cap is placed over the cut nerve end to protect it and may help reduce chronic nerve pain. The goal is to see if the cap is safe and works well befo…

This study tests a new type of prosthetic socket and liner designed to better distribute pressure on the remaining limb. Combined with an exercise program, the goal is to help people who lost a leg due to diabetes walk more and improve their health. About 38 participants who alre…

This study compares three different prosthetic liners designed to handle sweating inside an artificial leg. About 180 people with a below-knee amputation who currently have sweat problems will test each liner. The goal is to see which liner helps them feel more stable, secure, an…

This study tests whether smartphone and wearable sensors can help create personalized mobility plans for people who use lower-limb prostheses. Researchers will analyze sensor data along with walking tests and interviews to identify physical or psychological barriers to using the …

This study looks at how skin temperature and blood flow change in people with a leg amputation, especially those with diabetes. Researchers will test two types of prosthetic legs—rigid and shock-absorbing—to see which one keeps the skin cooler and healthier. Sixty participants wi…

This study aimed to help people with upper limb amputations feel their prosthetic hand as part of their own body. Researchers planned to use nerve stimulation to create touch and position sensations. The study was withdrawn before any participants were enrolled, so no results are…

This study tests whether a 40-week biofeedback training program can help people with a leg prosthesis (attached directly to the bone) walk with more equal weight on both legs. Fifteen participants will either receive the training or standard education. Researchers will measure fe…

This study is testing a new type of prosthetic hand that uses ultrasound to read muscle movements, instead of the usual electrical sensors. The goal is to see if this makes the hand easier and more natural to control. Sixteen people with below-elbow amputations will compare the n…

This study reviews the medical records of 20 adults who had a limb amputated to relieve severe, long-lasting pain from complex regional pain syndrome (CRPS). Researchers want to measure how many days pass between the amputation and when patients first use a functional prosthetic …

This study was designed to explore what kinds of feelings (like touch or tingling) could be created by electrically stimulating the spinal cord in people with amputations who experience phantom limb pain. Researchers planned to work with patients who already had a spinal cord sti…